Etiology of Breast Implant-Associated Anaplastic Large Cell
Lymphoma (BIA-ALCL): Current Directions in Research

J 2020

Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research

DEVA, A.K.; Suzanne Dawn TURNER; M.E. KADIN; M.R. MAGNUSSON; H.M. PRINCE et al.

Základní údaje

Originální název

Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research

Autoři

DEVA, A.K.; Suzanne Dawn TURNER; M.E. KADIN; M.R. MAGNUSSON; H.M. PRINCE; R.N. MIRANDA; G.G. INGHIRAMI a W.P. ADAMS

Vydání

Cancers, BASEL, MDPI, 2020, 2072-6694

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.639

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/20:00118309

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

antigens; bacterial; breast implants; lymphoma; T-cells

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 3. 2021 18:17, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Simple Summary The first report of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) was in 1997. Although BIA-ALCL develops around breast implants, it is considered a cancer of the immune system and not a cancer of the breast ducts or lobules. Nearly all confirmed cases to date have been associated with textured surface (versus smooth surface) breast implants. As physicians have become more aware of BIA-ALCL, so has the number of reported cases, although the number of cases remains low. In most instances, patients have an excellent prognosis following removal of the breast implant and its surrounding fibrous capsule. Many theories on factors that trigger the development of BIA-ALCL, such as the presence of bacteria, have been proposed. However, the sequence(s) of events that follow the initial triggering event(s) have not been fully determined. This article summarizes the current scientific knowledge on the development of BIA-ALCL. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase-negative T-cell lymphoma. Where implant history is known, all confirmed cases to date have occurred in patients with exposure to textured implants. There is a spectrum of disease presentation, with the most common occurring as a seroma with an indolent course. A less common presentation occurs as locally advanced or, rarely, as metastatic disease. Here we review the immunological characteristics of BIA-ALCL and potential triggers leading to its development. BIA-ALCL occurs in an inflammatory microenvironment with significant lymphocyte and plasma cell infiltration and a prominent Th1/Th17 phenotype in advanced disease. Genetic lesions affecting the JAK/STAT signaling pathway are commonly present. Proposed triggers for the development of malignancy include mechanical friction, silicone implant shell particulates, silicone leachables, and bacteria. Of these, the bacterial hypothesis has received significant attention, supported by a plausible biologic model. In this model, bacteria form an adherent biofilm in the favorable environment of the textured implant surface, producing a bacterial load that elicits a chronic inflammatory response. Bacterial antigens, primarily of Gram-negative origin, may trigger innate immunity and induce T-cell proliferation with subsequent malignant transformation in genetically susceptible individuals. Although much remains to be elucidated regarding the multifactorial origins of BIA-ALCL, future research should focus on prevention and treatment strategies, recognizing susceptible populations, and whether decreasing the risk of BIA-ALCL is possible.

Citovat

DEVA, A.K.; Suzanne Dawn TURNER; M.E. KADIN; M.R. MAGNUSSON; H.M. PRINCE; R.N. MIRANDA; G.G. INGHIRAMI a W.P. ADAMS. Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research. Cancers. BASEL: MDPI, 2020, roč. 12, č. 12, s. 3861-3874. ISSN 2072-6694. Dostupné z: https://doi.org/10.3390/cancers12123861.

@article{1748100,
   author = {Deva, A.K. and Turner, Suzanne Dawn and Kadin, M.E. and Magnusson, M.R. and Prince, H.M. and Miranda, R.N. and Inghirami, G.G. and Adams, W.P.},
   article_location = {BASEL},
   article_number = {12},
   doi = {https://doi.org/10.3390/cancers12123861},
   keywords = {antigens; bacterial; breast implants; lymphoma; T-cells},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research},
   url = {https://www.mdpi.com/2072-6694/12/12/3861},
   volume = {12},
   year = {2020}
}

TY  - JOUR
ID  - 1748100
AU  - Deva, A.K. - Turner, Suzanne Dawn - Kadin, M.E. - Magnusson, M.R. - Prince, H.M. - Miranda, R.N. - Inghirami, G.G. - Adams, W.P.
PY  - 2020
TI  - Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research
JF  - Cancers
VL  - 12
IS  - 12
SP  - 3861
EP  - 3861
PB  - MDPI
SN  - 20726694
KW  - antigens
KW  - bacterial
KW  - breast implants
KW  - lymphoma
KW  - T-cells
UR  - https://www.mdpi.com/2072-6694/12/12/3861
N2  - Simple Summary The first report of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) was in 1997. Although BIA-ALCL develops around breast implants, it is considered a cancer of the immune system and not a cancer of the breast ducts or lobules. Nearly all confirmed cases to date have been associated with textured surface (versus smooth surface) breast implants. As physicians have become more aware of BIA-ALCL, so has the number of reported cases, although the number of cases remains low. In most instances, patients have an excellent prognosis following removal of the breast implant and its surrounding fibrous capsule. Many theories on factors that trigger the development of BIA-ALCL, such as the presence of bacteria, have been proposed. However, the sequence(s) of events that follow the initial triggering event(s) have not been fully determined. This article summarizes the current scientific knowledge on the development of BIA-ALCL. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase-negative T-cell lymphoma. Where implant history is known, all confirmed cases to date have occurred in patients with exposure to textured implants. There is a spectrum of disease presentation, with the most common occurring as a seroma with an indolent course. A less common presentation occurs as locally advanced or, rarely, as metastatic disease. Here we review the immunological characteristics of BIA-ALCL and potential triggers leading to its development. BIA-ALCL occurs in an inflammatory microenvironment with significant lymphocyte and plasma cell infiltration and a prominent Th1/Th17 phenotype in advanced disease. Genetic lesions affecting the JAK/STAT signaling pathway are commonly present. Proposed triggers for the development of malignancy include mechanical friction, silicone implant shell particulates, silicone leachables, and bacteria. Of these, the bacterial hypothesis has received significant attention, supported by a plausible biologic model. In this model, bacteria form an adherent biofilm in the favorable environment of the textured implant surface, producing a bacterial load that elicits a chronic inflammatory response. Bacterial antigens, primarily of Gram-negative origin, may trigger innate immunity and induce T-cell proliferation with subsequent malignant transformation in genetically susceptible individuals. Although much remains to be elucidated regarding the multifactorial origins of BIA-ALCL, future research should focus on prevention and treatment strategies, recognizing susceptible populations, and whether decreasing the risk of BIA-ALCL is possible.
ER  -

DEVA, A.K.; Suzanne Dawn TURNER; M.E. KADIN; M.R. MAGNUSSON; H.M. PRINCE; R.N. MIRANDA; G.G. INGHIRAMI a W.P. ADAMS. Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research. \textit{Cancers}. BASEL: MDPI, 2020, roč.~12, č.~12, s.~3861-3874. ISSN~2072-6694. Dostupné z: https://doi.org/10.3390/cancers12123861.

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