miR-181a-2*expression is different amongst carcinomas from the
colorectal serrated route

J 2020

miR-181a-2*expression is different amongst carcinomas from the colorectal serrated route

KONDELOVÁ, Alexandra, B. ALBURQUERQUE-GONZALEZ, Petra VYCHYTILOVÁ, J. GARCIA-SOLANO, V. PROCHAZKA et. al.

Základní údaje

Originální název

miR-181a-2*expression is different amongst carcinomas from the colorectal serrated route

Autoři

KONDELOVÁ, Alexandra (703 Slovensko, domácí), B. ALBURQUERQUE-GONZALEZ, Petra VYCHYTILOVÁ (203 Česká republika, domácí), J. GARCIA-SOLANO, V. PROCHAZKA, Z. KALA, F. PEREZ, Ondřej SLABÝ (203 Česká republika, garant, domácí) a P. CONESA-ZAMORA

Vydání

MUTAGENESIS, OXFORD, OXFORD UNIV PRESS, 2020, 0267-8357

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10603 Genetics and heredity

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000

Kód RIV

RIV/00216224:14740/20:00118649

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1093/mutage/gez039

UT WoS

000593117600003

Klíčová slova anglicky

CPG ISLAND METHYLATION; MICROSATELLITE INSTABILITY; BRAF MUTATION; CANCER; EXPRESSION; POLYPS; ADENOCARCINOMA; MICRORNA-31; BIOMARKERS; ADENOMAS

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 3. 2021 13:42, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Serrated adenocarcinoma (SAC) and colorectal carcinomas showing histological and molecular features of high-level of microsatellite instability (hmMSI-H) are both end points of the serrated pathway of colorectal carcinogenesis. Despite common features (right-sided location, CpG island methylation phenotype and BRAF mutation) there are no studies comparing the microRNA (miRNA) expression profiles in SACs and hmMSI-H.The microtranscriptome from 12 SACs and 8 hmMSI-H were analysed using Affymetrix GeneChip miRNA 3.0 arrays and differentially enriched functions involving immune response were observed from this comparison. miR-181a-2* was found significantly more expressed in hmMSI-H than in SAC and higher expression of this miRNA in microsatellite unstable colorectal cancer were corroborated by Real-Time PCR in an extended series (61 SAC, 21 hmMSI-H). An analysis of genes possibly regulated by miR-181a-2* was carried out and, amongst these, an inverse correlation of NAMPT with miR-181a-2* expression was observed, whereas, for TRAF1 and SALL1, additional regulation mechanisms involving CpG island methylation were observed. miR-181a-2* is associated with particular histological and molecular features of colorectal carcinomas within the serrated pathological pathway and might play a role in the immune responses of microsatellite instability carcinomas.

Návaznosti

NV16-31765A, projekt VaV

Název: Využití tkáňových/cirkulujících mikroRNA pro predikci léčebné odpovědi a zpřesnění restagingu karcinomu rekta po neoadjuvantní léčbě

Citovat

KONDELOVÁ, Alexandra, B. ALBURQUERQUE-GONZALEZ, Petra VYCHYTILOVÁ, J. GARCIA-SOLANO, V. PROCHAZKA, Z. KALA, F. PEREZ, Ondřej SLABÝ a P. CONESA-ZAMORA. miR-181a-2*expression is different amongst carcinomas from the colorectal serrated route. MUTAGENESIS. OXFORD: OXFORD UNIV PRESS, 2020, roč. 35, č. 3, s. 233-241. ISSN 0267-8357. Dostupné z: https://dx.doi.org/10.1093/mutage/gez039.

@article{1749656,
   author = {Kondelová, Alexandra and AlburquerqueandGonzalez, B. and Vychytilová, Petra and GarciaandSolano, J. and Prochazka, V. and Kala, Z. and Perez, F. and Slabý, Ondřej and ConesaandZamora, P.},
   article_location = {OXFORD},
   article_number = {3},
   doi = {http://dx.doi.org/10.1093/mutage/gez039},
   keywords = {CPG ISLAND METHYLATION; MICROSATELLITE INSTABILITY; BRAF MUTATION; CANCER; EXPRESSION; POLYPS; ADENOCARCINOMA; MICRORNA-31; BIOMARKERS; ADENOMAS},
   language = {eng},
   issn = {0267-8357},
   journal = {MUTAGENESIS},
   title = {miR-181a-2*expression is different amongst carcinomas from the colorectal serrated route},
   url = {https://academic.oup.com/mutage/article-abstract/35/3/233/5648152?redirectedFrom=fulltext},
   volume = {35},
   year = {2020}
}

TY  - JOUR
ID  - 1749656
AU  - Kondelová, Alexandra - Alburquerque-Gonzalez, B. - Vychytilová, Petra - Garcia-Solano, J. - Prochazka, V. - Kala, Z. - Perez, F. - Slabý, Ondřej - Conesa-Zamora, P.
PY  - 2020
TI  - miR-181a-2*expression is different amongst carcinomas from the colorectal serrated route
JF  - MUTAGENESIS
VL  - 35
IS  - 3
SP  - 233-241
EP  - 233-241
PB  - OXFORD UNIV PRESS
SN  - 02678357
KW  - CPG ISLAND METHYLATION
KW  - MICROSATELLITE INSTABILITY
KW  - BRAF MUTATION
KW  - CANCER
KW  - EXPRESSION
KW  - POLYPS
KW  - ADENOCARCINOMA
KW  - MICRORNA-31
KW  - BIOMARKERS
KW  - ADENOMAS
UR  - https://academic.oup.com/mutage/article-abstract/35/3/233/5648152?redirectedFrom=fulltext
N2  - Serrated adenocarcinoma (SAC) and colorectal carcinomas showing histological and molecular features of high-level of microsatellite instability (hmMSI-H) are both end points of the serrated pathway of colorectal carcinogenesis. Despite common features (right-sided location, CpG island methylation phenotype and BRAF mutation) there are no studies comparing the microRNA (miRNA) expression profiles in SACs and hmMSI-H.The microtranscriptome from 12 SACs and 8 hmMSI-H were analysed using Affymetrix GeneChip miRNA 3.0 arrays and differentially enriched functions involving immune response were observed from this comparison. miR-181a-2* was found significantly more expressed in hmMSI-H than in SAC and higher expression of this miRNA in microsatellite unstable colorectal cancer were corroborated by Real-Time PCR in an extended series (61 SAC, 21 hmMSI-H). An analysis of genes possibly regulated by miR-181a-2* was carried out and, amongst these, an inverse correlation of NAMPT with miR-181a-2* expression was observed, whereas, for TRAF1 and SALL1, additional regulation mechanisms involving CpG island methylation were observed. miR-181a-2* is associated with particular histological and molecular features of colorectal carcinomas within the serrated pathological pathway and might play a role in the immune responses of microsatellite instability carcinomas.
ER  -

KONDELOVÁ, Alexandra, B. ALBURQUERQUE-GONZALEZ, Petra VYCHYTILOVÁ, J. GARCIA-SOLANO, V. PROCHAZKA, Z. KALA, F. PEREZ, Ondřej SLABÝ a P. CONESA-ZAMORA. miR-181a-2*expression is different amongst carcinomas from the colorectal serrated route. \textit{MUTAGENESIS}. OXFORD: OXFORD UNIV PRESS, 2020, roč.~35, č.~3, s.~233-241. ISSN~0267-8357. Dostupné z: https://dx.doi.org/10.1093/mutage/gez039.

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