| BRENNA, E., Alexey Nikolayevich DAVYDOV, K. LADELL, J.E. MCLAREN, P. BONAIUTI, Maria METSGER, J.D. RAMSDEN, S.C. GILBERT, T. LAMBE, D.A. PRICE, S.L. CAMPION, Dmitriy CHUDAKOV, P. BORROW a A.J. MCMICHAEL. CD4(+) T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4(+) Cells. Cell Reports. CAMBRIDGE: Cell Press, 2020, roč. 30, č. 1, s. "137"-"+", 21 s. ISSN 2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2019.12.016. |
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@article{1752779,
author = {Brenna, E. and Davydov, Alexey Nikolayevich and Ladell, K. and McLaren, J.E. and Bonaiuti, P. and Metsger, Maria and Ramsden, J.D. and Gilbert, S.C. and Lambe, T. and Price, D.A. and Campion, S.L. and Chudakov, Dmitriy and Borrow, P. and McMichael, A.J.},
article_location = {CAMBRIDGE},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.celrep.2019.12.016},
keywords = {GERMINAL CENTER RESPONSES; CXC CHEMOKINE RECEPTOR-5; B-CELLS; ANTIBODY-RESPONSES; INFLUENZA-VIRUS; HUMAN NAIVE; MEMORY; ANTIGEN; DIFFERENTIATION; INFECTION},
language = {eng},
issn = {2211-1247},
journal = {Cell Reports},
title = {CD4(+) T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4(+) Cells},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2211124719316663},
volume = {30},
year = {2020}
}
TY - JOUR
ID - 1752779
AU - Brenna, E. - Davydov, Alexey Nikolayevich - Ladell, K. - McLaren, J.E. - Bonaiuti, P. - Metsger, Maria - Ramsden, J.D. - Gilbert, S.C. - Lambe, T. - Price, D.A. - Campion, S.L. - Chudakov, Dmitriy - Borrow, P. - McMichael, A.J.
PY - 2020
TI - CD4(+) T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4(+) Cells
JF - Cell Reports
VL - 30
IS - 1
SP - "137"-"+"
EP - "137"-"+"
PB - Cell Press
SN - 22111247
KW - GERMINAL CENTER RESPONSES
KW - CXC CHEMOKINE RECEPTOR-5
KW - B-CELLS
KW - ANTIBODY-RESPONSES
KW - INFLUENZA-VIRUS
KW - HUMAN NAIVE
KW - MEMORY
KW - ANTIGEN
KW - DIFFERENTIATION
KW - INFECTION
UR - https://linkinghub.elsevier.com/retrieve/pii/S2211124719316663
N2 - T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4(+) T cells in peripheral blood, but their clonotypic relationship to Tfh populations resident in lymph nodes and the extent to which they differ from non-Tfh CD4(+) cells have been unclear. Using donor-matched blood and tonsil samples, we investigate T cell receptor (TCR) sharing between tonsillar Tfh cells and peripheral Tfh and non-Tfh cell populations. TCR transcript sequencing reveals considerable clonal overlap between peripheral and tonsillar Tfh cell subsets as well as a clear distinction between Tfh and non-Tfh cells. Furthermore, influenza-specific cTfh cell clones derived from blood can be found in the repertoire of tonsillar Tfh cells. Therefore, human blood samples can be used to gain insight into the specificity of Tfh responses occurring in lymphoid tissues, provided that cTfh subsets are studied.
ER -
BRENNA, E., Alexey Nikolayevich DAVYDOV, K. LADELL, J.E. MCLAREN, P. BONAIUTI, Maria METSGER, J.D. RAMSDEN, S.C. GILBERT, T. LAMBE, D.A. PRICE, S.L. CAMPION, Dmitriy CHUDAKOV, P. BORROW a A.J. MCMICHAEL. CD4(+) T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4(+) Cells. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2020, roč.~30, č.~1, s.~''137''-''+'', 21 s. ISSN~2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2019.12.016.
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