| GALLETTI, G., G. DE SIMONE, E.M.C. MAZZA, S. PUCCIO, C¨. MEZZANOTTE, T.M. BI, Alexey Nikolayevich DAVYDOV, Maria METSGER, E. SCAMARDELLA, G. ALVISI, F. DE PAOLI, V. ZANON, A. SCARPA, B. CAMISA, F.S. COLOMBO, A. ANSELMO, C. PEANO, S. POLLETTI, D. MAVILIO, L. GATTINONI, S.K. BOI, B.A. YOUNGBLOOD, R.E. JONES, D.M. BAIRD, E. GOSTICK, S. LLEWELLYN-LACEY, K. LADELL, D.A. PRICE, D.M. CHUDAKOV, E.W. NEWELL, M. CASUCCI a E. LUGLI. Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans. Nature immunology. NEW YORK: NATURE PUBLISHING GROUP, 2020, roč. 21, č. 12, s. "1552"-"+", 14 s. ISSN 1529-2908. Dostupné z: https://dx.doi.org/10.1038/s41590-020-0791-5. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1752796,
author = {Galletti, G. and De Simone, G. and Mazza, E.M.C. and Puccio, S. and Mezzanotte, C¨. and Bi, T.M. and Davydov, Alexey Nikolayevich and Metsger, Maria and Scamardella, E. and Alvisi, G. and De Paoli, F. and Zanon, V. and Scarpa, A. and Camisa, B. and Colombo, F.S. and Anselmo, A. and Peano, C. and Polletti, S. and Mavilio, D. and Gattinoni, L. and Boi, S.K. and Youngblood, B.A. and Jones, R.E. and Baird, D.M. and Gostick, E. and LlewellynandLacey, S. and Ladell, K. and Price, D.A. and Chudakov, D.M. and Newell, E.W. and Casucci, M. and Lugli, E.},
article_location = {NEW YORK},
article_number = {12},
doi = {http://dx.doi.org/10.1038/s41590-020-0791-5},
keywords = {DIFFERENTIATION; EXHAUSTION; EFFECTOR; EXPRESSION; STATES; PD-1; RECONSTITUTION; DYSFUNCTION; INFECTION; CHROMATIN},
language = {eng},
issn = {1529-2908},
journal = {Nature immunology},
title = {Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans},
url = {https://www.nature.com/articles/s41590-020-0791-5},
volume = {21},
year = {2020}
}
TY - JOUR
ID - 1752796
AU - Galletti, G. - De Simone, G. - Mazza, E.M.C. - Puccio, S. - Mezzanotte, C¨. - Bi, T.M. - Davydov, Alexey Nikolayevich - Metsger, Maria - Scamardella, E. - Alvisi, G. - De Paoli, F. - Zanon, V. - Scarpa, A. - Camisa, B. - Colombo, F.S. - Anselmo, A. - Peano, C. - Polletti, S. - Mavilio, D. - Gattinoni, L. - Boi, S.K. - Youngblood, B.A. - Jones, R.E. - Baird, D.M. - Gostick, E. - Llewellyn-Lacey, S. - Ladell, K. - Price, D.A. - Chudakov, D.M. - Newell, E.W. - Casucci, M. - Lugli, E.
PY - 2020
TI - Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans
JF - Nature immunology
VL - 21
IS - 12
SP - "1552"-"+"
EP - "1552"-"+"
PB - NATURE PUBLISHING GROUP
SN - 15292908
KW - DIFFERENTIATION
KW - EXHAUSTION
KW - EFFECTOR
KW - EXPRESSION
KW - STATES
KW - PD-1
KW - RECONSTITUTION
KW - DYSFUNCTION
KW - INFECTION
KW - CHROMATIN
UR - https://www.nature.com/articles/s41590-020-0791-5
N2 - The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells-one giving rise to a functional lineage, the other to an exhausted-like one. T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA-sequencing data to map the organizational structure of the human CD8(+)memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally distinct stem-like CD8(+)memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data reveal the existence of parallel differentiation programs in the human CD8(+)memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.
ER -
GALLETTI, G., G. DE SIMONE, E.M.C. MAZZA, S. PUCCIO, C¨. MEZZANOTTE, T.M. BI, Alexey Nikolayevich DAVYDOV, Maria METSGER, E. SCAMARDELLA, G. ALVISI, F. DE PAOLI, V. ZANON, A. SCARPA, B. CAMISA, F.S. COLOMBO, A. ANSELMO, C. PEANO, S. POLLETTI, D. MAVILIO, L. GATTINONI, S.K. BOI, B.A. YOUNGBLOOD, R.E. JONES, D.M. BAIRD, E. GOSTICK, S. LLEWELLYN-LACEY, K. LADELL, D.A. PRICE, D.M. CHUDAKOV, E.W. NEWELL, M. CASUCCI a E. LUGLI. Two subsets of stem-like CD8(+)memory T cell progenitors with distinct fate commitments in humans. \textit{Nature immunology}. NEW YORK: NATURE PUBLISHING GROUP, 2020, roč.~21, č.~12, s.~''1552''-''+'', 14 s. ISSN~1529-2908. Dostupné z: https://dx.doi.org/10.1038/s41590-020-0791-5.
|
