Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting
Galactoclusters and Their Interactions with Bacterial Lectin
PA-IL from Pseudomonas aeruginosa

J 2021

Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa

ILLYÉS, Tünde Zita; Lenka MALINOVSKÁ; Erzsébet RŐTH; Boglárka TÓTH; Bence FARKAS et al.

Základní údaje

Originální název

Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa

Autoři

ILLYÉS, Tünde Zita; Lenka MALINOVSKÁ ; Erzsébet RŐTH; Boglárka TÓTH; Bence FARKAS; Marek KORSÁK; Michaela WIMMEROVÁ; Katalin E. KÖVÉR a Magdolna CSÁVÁS

Vydání

Molecules, Basel, MDPI, 2021, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.927

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00118897

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

selenoglycosides; galactoclusters; Pseudomonas aeruginosa; PA-IL lectin; multivalency

Štítky

14313050, 143160, CF BIC, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 10. 2024 15:20, Ing. Martina Blahová

Anotace

V originále

Synthesis of tetravalent thio- and selenogalactopyranoside-containing glycoclusters using azide-alkyne click strategy is presented. Prepared compounds are potential ligands of Pseudomonas aeruginosa lectin PA-IL. P. aeruginosa is an opportunistic human pathogen associated with cystic fibrosis, and PA-IL is one of its virulence factors. The interactions of PA-IL and tetravalent glycoconjugates were investigated using hemagglutination inhibition assay and compared with mono- and divalent galactosides (propargyl 1-thio- and 1-seleno-beta-d-galactopyranoside, digalactosyl diselenide and digalactosyl disulfide). The lectin-carbohydrate interactions were also studied by saturation transfer difference NMR technique. Both thio- and seleno-tetravalent glycoconjugates were able to inhibit PA-IL significantly better than simple d-galactose or their intermediate compounds from the synthesis.

Návaznosti

GA18-18964S, projekt VaV

Název: Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání

Investor: Grantová agentura ČR, Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání

LM2018131, projekt VaV

Název: Česká národní infrastruktura pro biologická data (Akronym: ELIXIR-CZ)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Česká národní infrastruktura pro biologická data

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

ILLYÉS, Tünde Zita; Lenka MALINOVSKÁ; Erzsébet RŐTH; Boglárka TÓTH; Bence FARKAS; Marek KORSÁK; Michaela WIMMEROVÁ; Katalin E. KÖVÉR a Magdolna CSÁVÁS. Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa. Molecules. Basel: MDPI, 2021, roč. 26, č. 3, s. "542-1"-"542-11", 11 s. ISSN 1420-3049. Dostupné z: https://doi.org/10.3390/molecules26030542.

@article{1753476,
   author = {Illyés, Tünde Zita and Malinovská, Lenka and Rőth, Erzsébet and Tóth, Boglárka and Farkas, Bence and Korsák, Marek and Wimmerová, Michaela and Kövér, Katalin E. and Csávás, Magdolna},
   article_location = {Basel},
   article_number = {3},
   doi = {https://doi.org/10.3390/molecules26030542},
   keywords = {selenoglycosides; galactoclusters; Pseudomonas aeruginosa; PA-IL lectin; multivalency},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa},
   url = {https://doi.org/10.3390/molecules26030542},
   volume = {26},
   year = {2021}
}

TY  - JOUR
ID  - 1753476
AU  - Illyés, Tünde Zita - Malinovská, Lenka - Rőth, Erzsébet - Tóth, Boglárka - Farkas, Bence - Korsák, Marek - Wimmerová, Michaela - Kövér, Katalin E. - Csávás, Magdolna
PY  - 2021
TI  - Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa
JF  - Molecules
VL  - 26
IS  - 3
SP  - "542-1"-"542-11"
EP  - "542-1"-"542-11"
PB  - MDPI
SN  - 14203049
KW  - selenoglycosides
KW  - galactoclusters
KW  - Pseudomonas aeruginosa
KW  - PA-IL lectin
KW  - multivalency
UR  - https://doi.org/10.3390/molecules26030542
N2  - Synthesis of tetravalent thio- and selenogalactopyranoside-containing glycoclusters using azide-alkyne click strategy is presented. Prepared compounds are potential ligands of Pseudomonas aeruginosa lectin PA-IL. P. aeruginosa is an opportunistic human pathogen associated with cystic fibrosis, and PA-IL is one of its virulence factors. The interactions of PA-IL and tetravalent glycoconjugates were investigated using hemagglutination inhibition assay and compared with mono- and divalent galactosides (propargyl 1-thio- and 1-seleno-beta-d-galactopyranoside, digalactosyl diselenide and digalactosyl disulfide). The lectin-carbohydrate interactions were also studied by saturation transfer difference NMR technique. Both thio- and seleno-tetravalent glycoconjugates were able to inhibit PA-IL significantly better than simple d-galactose or their intermediate compounds from the synthesis.
ER  -

ILLYÉS, Tünde Zita; Lenka MALINOVSKÁ; Erzsébet R$\backslash$H OTH; Boglárka TÓTH; Bence FARKAS; Marek KORSÁK; Michaela WIMMEROVÁ; Katalin E. KÖVÉR a Magdolna CSÁVÁS. Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa. \textit{Molecules}. Basel: MDPI, 2021, roč.~26, č.~3, s.~''542-1''-''542-11'', 11 s. ISSN~1420-3049. Dostupné z: https://doi.org/10.3390/molecules26030542.

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