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@article{1755496,
author = {Bjorklund, G. and Meguid, N. A. and ElandBana, M. A. and Tinkov, A. A. and Saad, K. and Dadar, M. and Hemimi, M. and Skalny, A. V. and Hosnedlova, B. and Kizek, René and Osredkar, J. and Urbina, M. A. and Fabjan, T. and ElandHoufey, A. A. and KaluznaandCzaplinska, J. and Gatarek, P. and Chirumbolo, S.},
article_location = {New York},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s12035-019-01742-2},
keywords = {Autism; Oxidative stress; Reactive oxygen species; Inflammation; ASD},
language = {eng},
issn = {0893-7648},
journal = {Molecular Neurobiology},
title = {Oxidative Stress in Autism Spectrum Disorder},
url = {https://pubmed.ncbi.nlm.nih.gov/32026227/},
volume = {57},
year = {2020}
}
TY - JOUR
ID - 1755496
AU - Bjorklund, G. - Meguid, N. A. - El-Bana, M. A. - Tinkov, A. A. - Saad, K. - Dadar, M. - Hemimi, M. - Skalny, A. V. - Hosnedlova, B. - Kizek, René - Osredkar, J. - Urbina, M. A. - Fabjan, T. - El-Houfey, A. A. - Kaluzna-Czaplinska, J. - Gatarek, P. - Chirumbolo, S.
PY - 2020
TI - Oxidative Stress in Autism Spectrum Disorder
JF - Molecular Neurobiology
VL - 57
IS - 5
SP - 2314-2332
EP - 2314-2332
PB - Springer
SN - 08937648
KW - Autism
KW - Oxidative stress
KW - Reactive oxygen species
KW - Inflammation
KW - ASD
UR - https://pubmed.ncbi.nlm.nih.gov/32026227/
N2 - According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with an autism spectrum disorder (ASD) was 1 in 68 (1.46%) among 8-year-old children born in 2004 and living within the 11 monitoring sites' surveillance areas in the United States of America (USA) in 2012. ASD is a multifaceted neurodevelopmental disorder that is also considered a hidden disability, as, for the most part; there are no apparent morphological differences between children with ASD and typically developing children. ASD is diagnosed based upon a triad of features including impairment in socialization, impairment in language, and repetitive and stereotypic behaviors. The increasing incidence of ASD in the pediatric population and the lack of successful curative therapies make ASD one of the most challenging disorders for medicine. ASD neurobiology is thought to be associated with oxidative stress, as shown by increased levels of reactive oxygen species and increased lipid peroxidation, as well as an increase in other indicators of oxidative stress. Children with ASD diagnosis are considered more vulnerable to oxidative stress because of their imbalance in intracellular and extracellular glutathione levels and decreased glutathione reserve capacity. Several studies have suggested that the redox imbalance and oxidative stress are integral parts of ASD pathophysiology. As such, early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage. In this review, many aspects of the role of oxidative stress in ASD are discussed, taking into account that the process of oxidative stress may be a target for therapeutic interventions.
ER -
BJORKLUND, G., N. A. MEGUID, M. A. EL-BANA, A. A. TINKOV, K. SAAD, M. DADAR, M. HEMIMI, A. V. SKALNY, B. HOSNEDLOVA, René KIZEK, J. OSREDKAR, M. A. URBINA, T. FABJAN, A. A. EL-HOUFEY, J. KALUZNA-CZAPLINSKA, P. GATAREK a S. CHIRUMBOLO. Oxidative Stress in Autism Spectrum Disorder. \textit{Molecular Neurobiology}. New York: Springer, 2020, roč.~57, č.~5, s.~2314-2332. ISSN~0893-7648. Dostupné z: https://dx.doi.org/10.1007/s12035-019-01742-2.
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