Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae

@article{1756937,
   author = {Krátká, Marie and Šmerda, Jakub and Lojdová, Kateřina and Bureš, Petr and Zedek, František},
   article_number = {February},
   doi = {http://dx.doi.org/10.3389/fpls.2021.642661},
   keywords = {asymmetric meiosis; centromere drive; CenH3; holocentric chromosomes; monocentric chromosomes; symmetric meiosis; meiotic drive},
   language = {eng},
   issn = {1664-462X},
   journal = {Frontiers in Plant Science},
   note = {K. Lojdová - středoškolská studentka na praxi.},
   title = {Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae},
   url = {https://www.frontiersin.org/articles/10.3389/fpls.2021.642661/full},
   volume = {12},
   year = {2021}
}

TY  - JOUR
ID  - 1756937
AU  - Krátká, Marie - Šmerda, Jakub - Lojdová, Kateřina - Bureš, Petr - Zedek, František
PY  - 2021
TI  - Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae
JF  - Frontiers in Plant Science
VL  - 12
IS  - February
SP  - "642661"
EP  - "642661"
PB  - Frontiers Media S.A.
SN  - 1664462X
N1  - K. Lojdová - středoškolská studentka na praxi.
KW  - asymmetric meiosis
KW  - centromere drive
KW  - CenH3
KW  - holocentric chromosomes
KW  - monocentric chromosomes
KW  - symmetric meiosis
KW  - meiotic drive
UR  - https://www.frontiersin.org/articles/10.3389/fpls.2021.642661/full
N2  - Centromere drive model describes an evolutionary process initiated by centromeric repeats expansion, which leads to the recruitment of excess kinetochore proteins and consequent preferential segregation of an expanded centromere to the egg during female asymmetric meiosis. In response to these selfish centromeres, the histone protein CenH3, which recruits kinetochore components, adaptively evolves to restore chromosomal parity and counter the detrimental effects of centromere drive. Holocentric chromosomes, whose kinetochores are assembled along entire chromosomes, have been hypothesized to prevent expanded centromeres from acquiring a selective advantage and initiating centromere drive. In such a case, CenH3 would be subjected to less frequent or no adaptive evolution. Using codon substitution models, we analyzed 36 CenH3 sequences from 35 species of the holocentric family Cyperaceae. We found 10 positively selected codons in the CenH3 gene [six codons in the N-terminus and four in the histone fold domain (HFD)] and six branches of its phylogeny along which the positive selection occurred. One of the positively selected codons was found in the centromere targeting domain (CATD) that directly interacts with DNA and its mutations may be important in centromere drive suppression. The frequency of these positive selection events was comparable to the frequency of positive selection in monocentric clades with asymmetric female meiosis. Taken together, these results suggest that preventing centromere drive is not the primary adaptive role of holocentric chromosomes, and their ability to suppress it likely depends on their kinetochore structure in meiosis.
ER  - 

KRÁTKÁ, Marie, Jakub ŠMERDA, Kateřina LOJDOVÁ, Petr BUREŠ a František ZEDEK. Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae. \textit{Frontiers in Plant Science}. Frontiers Media S.A., 2021, roč.~12, February, s.~''642661'', 9 s. ISSN~1664-462X. Dostupné z: https://dx.doi.org/10.3389/fpls.2021.642661.