Oxidized polysaccharides for anticancer-drug delivery: What is
the role of structure?

J 2021

Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

MUNSTER, Lukas; Michaela FOJTŮ; Zdenka CAPAKOVA; Monika MUCHOVA; Lenka MUSILOVA et. al.

Základní údaje

Originální název

Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

Autoři

MUNSTER, Lukas; Michaela FOJTŮ; Zdenka CAPAKOVA; Monika MUCHOVA; Lenka MUSILOVA; Tomáš VACULOVIČ; Jan BALVAN; Ivo KURITKA; Michal MASAŘÍK a Jan VICHA

Vydání

Carbohydrate Polymers, Oxford, ELSEVIER SCI LTD, 2021, 0144-8617

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10404 Polymer science

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.723

Kód RIV

RIV/00216224:14110/21:00121369

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.carbpol.2020.117562

UT WoS

000617787500009

EID Scopus

2-s2.0-85099000496

Klíčová slova anglicky

Drug delivery; Cellulose; Dextran; Dextrin; Sodium hyaluronate; Selective oxidation

Štítky

14110515, 14110518, 14313010, CF NMR, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 2. 2025 11:41, Mgr. Tereza Miškechová

Anotace

V originále

Study provides an in-depth analysis of the structure-function relationship of polysaccharide anticancer drug carriers and points out benefits and potential drawbacks of differences in polysaccharide glycosidic bonding, branching and drug binding mode of the carriers. Cellulose, dextrin, dextran and hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them to directly conjugate cisplatin, while preserving their major structural features intact. The structure of source polysaccharide has crucial impact on conjugation effectiveness, carrier capacity, drug release rates, in vitro cytotoxicity and cellular uptake. For example, while branched structure of dextrin-based carrier partially counter the undesirable initial burst release, it also attenuates the cellular uptake and the cytotoxicity of carried drug. Linear polysaccharides containing beta-(1 -> 4) glycosidic bonds and oxidized at C2 and C3 (cellulose and hyaluronate) have the best overall combination of structural features for improved drug delivery applications including potentiation of the cisplatin efficacy towards malignances.

Návaznosti

LM2018140, projekt VaV

Název: e-Infrastruktura CZ (Akronym: e-INFRA CZ)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, e-Infrastruktura CZ

ROZV/28/LF17/2020, interní kód MU

Název: Magnetoboti pro fototermální a magnetotermální terapii nádorových onemocnění

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Magnetoboti pro fototermální a magnetotermální terapii nádorových onemocnění, Interní rozvojové projekty

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

MUNSTER, Lukas; Michaela FOJTŮ; Zdenka CAPAKOVA; Monika MUCHOVA; Lenka MUSILOVA; Tomáš VACULOVIČ; Jan BALVAN; Ivo KURITKA; Michal MASAŘÍK a Jan VICHA. Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure? Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2021, roč. 257, APR 2021, s. 1-12. ISSN 0144-8617. Dostupné z: https://doi.org/10.1016/j.carbpol.2020.117562.

@article{1758099,
   author = {Munster, Lukas and Fojtů, Michaela and Capakova, Zdenka and Muchova, Monika and Musilova, Lenka and Vaculovič, Tomáš and Balvan, Jan and Kuritka, Ivo and Masařík, Michal and Vicha, Jan},
   article_location = {Oxford},
   article_number = {APR 2021},
   doi = {https://doi.org/10.1016/j.carbpol.2020.117562},
   keywords = {Drug delivery; Cellulose; Dextran; Dextrin; Sodium hyaluronate; Selective oxidation},
   language = {eng},
   issn = {0144-8617},
   journal = {Carbohydrate Polymers},
   title = {Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?},
   url = {https://www.sciencedirect.com/science/article/pii/S0144861720317355?via%3Dihub},
   volume = {257},
   year = {2021}
}

TY  - JOUR
ID  - 1758099
AU  - Munster, Lukas - Fojtů, Michaela - Capakova, Zdenka - Muchova, Monika - Musilova, Lenka - Vaculovič, Tomáš - Balvan, Jan - Kuritka, Ivo - Masařík, Michal - Vicha, Jan
PY  - 2021
TI  - Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?
JF  - Carbohydrate Polymers
VL  - 257
IS  - APR 2021
SP  - 1-12
EP  - 1-12
PB  - ELSEVIER SCI LTD
SN  - 01448617
KW  - Drug delivery
KW  - Cellulose
KW  - Dextran
KW  - Dextrin
KW  - Sodium hyaluronate
KW  - Selective oxidation
UR  - https://www.sciencedirect.com/science/article/pii/S0144861720317355?via%3Dihub
N2  - Study provides an in-depth analysis of the structure-function relationship of polysaccharide anticancer drug carriers and points out benefits and potential drawbacks of differences in polysaccharide glycosidic bonding, branching and drug binding mode of the carriers. Cellulose, dextrin, dextran and hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them to directly conjugate cisplatin, while preserving their major structural features intact. The structure of source polysaccharide has crucial impact on conjugation effectiveness, carrier capacity, drug release rates, in vitro cytotoxicity and cellular uptake. For example, while branched structure of dextrin-based carrier partially counter the undesirable initial burst release, it also attenuates the cellular uptake and the cytotoxicity of carried drug. Linear polysaccharides containing beta-(1 -> 4) glycosidic bonds and oxidized at C2 and C3 (cellulose and hyaluronate) have the best overall combination of structural features for improved drug delivery applications including potentiation of the cisplatin efficacy towards malignances.
ER  -

MUNSTER, Lukas; Michaela FOJTŮ; Zdenka CAPAKOVA; Monika MUCHOVA; Lenka MUSILOVA; Tomáš VACULOVIČ; Jan BALVAN; Ivo KURITKA; Michal MASAŘÍK a Jan VICHA. Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure? \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, roč.~257, APR 2021, s.~1-12. ISSN~0144-8617. Dostupné z: https://doi.org/10.1016/j.carbpol.2020.117562.

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