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@article{1761839,
author = {Holíková, Klára and Laakso, Hanne and Salo, Raimo and Shatillo, Artem and Nurmi, Antti and Bareš, Martin and Vaníček, Jiří and Michaeli, Shalom and Mangia, Silvia and Sierra, Alejandra and Grohn, Olli},
article_location = {Lausanne},
article_number = {MAR 2021},
doi = {http://dx.doi.org/10.3389/fnins.2021.625167},
keywords = {myelin; demyelination; remyelination; MRI; diffusion; rotating frame relaxation},
language = {eng},
issn = {1662-453X},
journal = {Frontiers in Neuroscience},
title = {RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats},
url = {https://www.frontiersin.org/articles/10.3389/fnins.2021.625167/full},
volume = {15},
year = {2021}
}
TY - JOUR
ID - 1761839
AU - Holíková, Klára - Laakso, Hanne - Salo, Raimo - Shatillo, Artem - Nurmi, Antti - Bareš, Martin - Vaníček, Jiří - Michaeli, Shalom - Mangia, Silvia - Sierra, Alejandra - Grohn, Olli
PY - 2021
TI - RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats
JF - Frontiers in Neuroscience
VL - 15
IS - MAR 2021
SP - 1-12
EP - 1-12
PB - Frontiers Media S.A.
SN - 1662453X
KW - myelin
KW - demyelination
KW - remyelination
KW - MRI
KW - diffusion
KW - rotating frame relaxation
UR - https://www.frontiersin.org/articles/10.3389/fnins.2021.625167/full
N2 - Remyelination is a naturally occurring response to demyelination and has a central role in the pathophysiology of multiple sclerosis and traumatic brain injury. Recently we demonstrated that a novel MRI technique entitled Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank n (RAFFn) achieved exceptional sensitivity in detecting the demyelination processes induced by lysophosphatidylcholine (LPC) in rat brain. In the present work, our aim was to test whether RAFF4, along with magnetization transfer (MT) and diffusion tensor imaging (DTI), would be capable of detecting the changes in the myelin content and microstructure caused by modifications of myelin sheets around axons or by gliosis during the remyelination phase after LPC-induced demyelination in the corpus callosum of rats. We collected MRI data with RAFF4, MT and DTI at 3 days after injection (demyelination stage) and at 38 days after injection (remyelination stage) of LPC (n = 12) or vehicle (n = 9). Cell density and myelin content were assessed by histology. All MRI metrics detected differences between LPC-injected and control groups of animals in the demyelination stage, on day 3. In the remyelination phase (day 38), RAFF4, MT parameters, fractional anisotropy, and axial diffusivity detected signs of a partial recovery consistent with the remyelination evident in histology. Radial diffusivity had undergone a further increase from day 3 to 38 and mean diffusivity revealed a complete recovery correlating with the histological assessment of cell density attributed to gliosis. The combination of RAFF4, MT and DTI has the potential to differentiate between normal, demyelinated and remyelinated axons and gliosis and thus it may be able to provide a more detailed assessment of white matter pathologies in several neurological diseases.
ER -
HOLÍKOVÁ, Klára, Hanne LAAKSO, Raimo SALO, Artem SHATILLO, Antti NURMI, Martin BAREŠ, Jiří VANÍČEK, Shalom MICHAELI, Silvia MANGIA, Alejandra SIERRA a Olli GROHN. RAFF-4, Magnetization Transfer and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats. \textit{Frontiers in Neuroscience}. Lausanne: Frontiers Media S.A., 2021, roč.~15, MAR 2021, s.~1-12. ISSN~1662-453X. Dostupné z: https://dx.doi.org/10.3389/fnins.2021.625167.
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