Extract from the Marine Seaweed Padina pavonica Protects
Mitochondrial Biomembranes from Damage by Amyloidogenic
Peptides

J 2021

Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides

CARUANA, Mario; Angelique CAMILLERI; Maria Ylenia FARRUGIA; Stephanie GHIO; Michaela JAKUBÍČKOVÁ et al.

Základní údaje

Originální název

Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides

Autoři

CARUANA, Mario; Angelique CAMILLERI; Maria Ylenia FARRUGIA; Stephanie GHIO; Michaela JAKUBÍČKOVÁ; Ruben J. CAUCHI a Neville VASSALLO

Vydání

Molecules, MDPI, 2021, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.927

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00121513

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Padina pavonica seaweed extract; Alzheimer’ s disease; Parkinson’ s disease; mitochondria; amyloidogenic proteins; membrane permeabilization

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 4. 2021 17:44, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an extract from the marine brown seaweed Padina pavonica (PPE) as a vital source of natural bioactive compounds to protect mitochondrial membranes against insult by oligomeric aggregates of the amyloidogenic proteins amyloid-beta (A beta), alpha-synuclein (alpha-syn) and tau, which are currently considered to be major targets for drug discovery in Alzheimer's disease (AD) and Parkinson's disease (PD). We show that PPE manifested a significant inhibitory effect against swelling of isolated mitochondria exposed to the amyloid oligomers, and attenuated the release of cytochrome c from the mitochondria. Using cardiolipin-enriched synthetic lipid membranes, we also show that dye leakage from fluorophore-loaded vesicles and formation of channel-like pores in planar bilayer membranes are largely prevented by incubating the oligomeric aggregates with PPE. Lastly, we demonstrate that PPE curtails the ability of A beta 42 and alpha-syn monomers to self-assemble into larger beta-aggregate structures, as well as potently disrupts their respective amyloid fibrils. In conclusion, the mito-protective and anti-aggregator biological activities of Padina pavonica extract may be of therapeutic value in neurodegenerative proteinopathies, such as AD and PD.

Citovat

CARUANA, Mario; Angelique CAMILLERI; Maria Ylenia FARRUGIA; Stephanie GHIO; Michaela JAKUBÍČKOVÁ; Ruben J. CAUCHI a Neville VASSALLO. Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides. Molecules. MDPI, 2021, roč. 26, č. 5, s. "1444", 17 s. ISSN 1420-3049. Dostupné z: https://doi.org/10.3390/molecules26051444.

@article{1764731,
   author = {Caruana, Mario and Camilleri, Angelique and Farrugia, Maria Ylenia and Ghio, Stephanie and Jakubíčková, Michaela and Cauchi, Ruben J. and Vassallo, Neville},
   article_number = {5},
   doi = {https://doi.org/10.3390/molecules26051444},
   keywords = {Padina pavonica seaweed extract; Alzheimer’ s disease; Parkinson’ s disease; mitochondria; amyloidogenic proteins; membrane permeabilization},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides},
   url = {https://www.mdpi.com/1420-3049/26/5/1444},
   volume = {26},
   year = {2021}
}

TY  - JOUR
ID  - 1764731
AU  - Caruana, Mario - Camilleri, Angelique - Farrugia, Maria Ylenia - Ghio, Stephanie - Jakubíčková, Michaela - Cauchi, Ruben J. - Vassallo, Neville
PY  - 2021
TI  - Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides
JF  - Molecules
VL  - 26
IS  - 5
SP  - "1444"
EP  - "1444"
PB  - MDPI
SN  - 14203049
KW  - Padina pavonica seaweed extract
KW  - Alzheimer’ s disease
KW  - Parkinson’ s disease
KW  - mitochondria
KW  - amyloidogenic proteins
KW  - membrane permeabilization
UR  - https://www.mdpi.com/1420-3049/26/5/1444
N2  - The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an extract from the marine brown seaweed Padina pavonica (PPE) as a vital source of natural bioactive compounds to protect mitochondrial membranes against insult by oligomeric aggregates of the amyloidogenic proteins amyloid-beta (A beta), alpha-synuclein (alpha-syn) and tau, which are currently considered to be major targets for drug discovery in Alzheimer's disease (AD) and Parkinson's disease (PD). We show that PPE manifested a significant inhibitory effect against swelling of isolated mitochondria exposed to the amyloid oligomers, and attenuated the release of cytochrome c from the mitochondria. Using cardiolipin-enriched synthetic lipid membranes, we also show that dye leakage from fluorophore-loaded vesicles and formation of channel-like pores in planar bilayer membranes are largely prevented by incubating the oligomeric aggregates with PPE. Lastly, we demonstrate that PPE curtails the ability of A beta 42 and alpha-syn monomers to self-assemble into larger beta-aggregate structures, as well as potently disrupts their respective amyloid fibrils. In conclusion, the mito-protective and anti-aggregator biological activities of Padina pavonica extract may be of therapeutic value in neurodegenerative proteinopathies, such as AD and PD.
ER  -

CARUANA, Mario; Angelique CAMILLERI; Maria Ylenia FARRUGIA; Stephanie GHIO; Michaela JAKUBÍČKOVÁ; Ruben J. CAUCHI a Neville VASSALLO. Extract from the Marine Seaweed Padina pavonica Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides. \textit{Molecules}. MDPI, 2021, roč.~26, č.~5, s.~''1444'', 17 s. ISSN~1420-3049. Dostupné z: https://doi.org/10.3390/molecules26051444.

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