HANKEOVÁ, Simona, Jakub ŠALPLACHTA, Tomáš ZIKMUND, Michaela KAVKOVÁ, Noemi VAN HUL, Adam BŘÍNEK, Veronika SMÉKALOVÁ, Jakub LÁZŇOVSKÝ, Feven DAWIT, Josef JAROŠ, Vítězslav BRYJA, Urban LENDAHL, Ewa ELLIS, Antal NEMETH, Bjorn FISCHLER, Edouard HANNEZO, Jozef KAISER a Emma Rachel ANDERSSON. DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome. eLife. eLife Sciences Publications Ltd, 2021, roč. 10, February, s. 1-29. ISSN 2050-084X. Dostupné z: https://dx.doi.org/10.7554/eLife.60916. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1765796, author = {Hankeová, Simona and Šalplachta, Jakub and Zikmund, Tomáš and Kavková, Michaela and Van Hul, Noemi and Břínek, Adam and Smékalová, Veronika and Lázňovský, Jakub and Dawit, Feven and Jaroš, Josef and Bryja, Vítězslav and Lendahl, Urban and Ellis, Ewa and Nemeth, Antal and Fischler, Bjorn and Hannezo, Edouard and Kaiser, Jozef and Andersson, Emma Rachel}, article_number = {February}, doi = {http://dx.doi.org/10.7554/eLife.60916}, keywords = {PORTAL-VEIN; ARTERIOHEPATIC DYSPLASIA; HEPATIC-ARTERY; HUMAN JAGGED1; LIVER; MUTATIONS; INSIGHTS; NETWORK; ORGAN}, language = {eng}, issn = {2050-084X}, journal = {eLife}, title = {DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome}, url = {https://elifesciences.org/articles/60916#xb0ffa41b}, volume = {10}, year = {2021} }
TY - JOUR ID - 1765796 AU - Hankeová, Simona - Šalplachta, Jakub - Zikmund, Tomáš - Kavková, Michaela - Van Hul, Noemi - Břínek, Adam - Smékalová, Veronika - Lázňovský, Jakub - Dawit, Feven - Jaroš, Josef - Bryja, Vítězslav - Lendahl, Urban - Ellis, Ewa - Nemeth, Antal - Fischler, Bjorn - Hannezo, Edouard - Kaiser, Jozef - Andersson, Emma Rachel PY - 2021 TI - DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome JF - eLife VL - 10 IS - February SP - 1-29 EP - 1-29 PB - eLife Sciences Publications Ltd SN - 2050084X KW - PORTAL-VEIN KW - ARTERIOHEPATIC DYSPLASIA KW - HEPATIC-ARTERY KW - HUMAN JAGGED1 KW - LIVER KW - MUTATIONS KW - INSIGHTS KW - NETWORK KW - ORGAN UR - https://elifesciences.org/articles/60916#xb0ffa41b N2 - Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digitalize, and segment the architecture of two tubular systems in 3D: double resin casting micro computed tomography (DUCT). As proof of principle, we applied DUCT to a mouse model for Alagille syndrome (Jag1(Ndr/Ndr) mice), characterized by intrahepatic bile duct paucity, that can spontaneously generate a biliary system in adulthood. DUCT identified increased central biliary branching and peripheral bile duct tortuosity as two compensatory processes occurring in distinct regions of Jag1(Ndr/Ndr) liver, leading to full reconstitution of wild-type biliary volume and phenotypic recovery. DUCT is thus a powerful new technology for 3D analysis, which can reveal novel phenotypes and provide a standardized method of defining liver architecture in mouse models. ER -
HANKEOVÁ, Simona, Jakub ŠALPLACHTA, Tomáš ZIKMUND, Michaela KAVKOVÁ, Noemi VAN HUL, Adam BŘÍNEK, Veronika SMÉKALOVÁ, Jakub LÁZŇOVSKÝ, Feven DAWIT, Josef JAROŠ, Vítězslav BRYJA, Urban LENDAHL, Ewa ELLIS, Antal NEMETH, Bjorn FISCHLER, Edouard HANNEZO, Jozef KAISER a Emma Rachel ANDERSSON. DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome. \textit{eLife}. eLife Sciences Publications Ltd, 2021, roč.~10, February, s.~1-29. ISSN~2050-084X. Dostupné z: https://dx.doi.org/10.7554/eLife.60916.
|