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@article{1766876,
author = {Furmanová, Katarína and Muren, Ludvig P and CasaresandMagaz, Oscar and Moiseenko, Vitali and Einck, John P and Pilskog, Sara and Raidou, Renata G},
article_number = {April},
doi = {http://dx.doi.org/10.1016/j.cag.2021.04.010},
keywords = {Medical Visualization; Visual Analytics; Comparative Visualization; Ensemble Visualization; Radiotherapy Planning; Cohort Study},
language = {eng},
issn = {0097-8493},
journal = {Computers & Graphics},
title = {PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support},
url = {https://www.sciencedirect.com/science/article/pii/S0097849321000522},
volume = {97},
year = {2021}
}
TY - JOUR
ID - 1766876
AU - Furmanová, Katarína - Muren, Ludvig P - Casares-Magaz, Oscar - Moiseenko, Vitali - Einck, John P - Pilskog, Sara - Raidou, Renata G
PY - 2021
TI - PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support
JF - Computers & Graphics
VL - 97
IS - April
SP - 126-138
EP - 126-138
PB - Elsevier Science
SN - 00978493
KW - Medical Visualization
KW - Visual Analytics
KW - Comparative Visualization
KW - Ensemble Visualization
KW - Radiotherapy Planning
KW - Cohort Study
UR - https://www.sciencedirect.com/science/article/pii/S0097849321000522
N2 - Radiotherapy (RT) requires meticulous planning prior to treatment, where the RT plan is optimized with organ delineations on a pre-treatment Computed Tomography (CT) scan of the patient. The conventionally fractionated treatment usually lasts several weeks. Random changes (e.g., rectal and bladder filling in prostate cancer patients) and systematic changes (e.g., weight loss) occur while the patient is being treated. Therefore, the delivered dose distribution may deviate from the planned. Modern technology, in particular image guidance, allows to minimize these deviations, but risks for the patient remain. We present PREVIS: a visual analytics tool for (i) the exploration and prediction of changes in patient anatomy during the upcoming treatment, and (ii) the assessment of treatment strategies, with respect to the anticipated changes. Records of during-treatment changes from a retrospective imaging cohort with complete data are employed in PREVIS, to infer expected anatomical changes of new incoming patients with incomplete data, using a generative model. Abstracted representations of the retrospective cohort partitioning provide insight into an underlying automated clustering, showing main modes of variation for past patients. Interactive similarity representations support an informed selection of matching between new incoming patients and past patients. A Principal Component Analysis (PCA)-based generative model describes the predicted spatial probability distributions of the incoming patient’s organs in the upcoming weeks of treatment, based on observations of past patients. The generative model is interactively linked to treatment plan evaluation, supporting the selection of the optimal treatment strategy. We present a usage scenario, demonstrating the applicability of PREVIS in a clinical research setting, and we evaluate our visual analytics tool with eight clinical researchers.
ER -
FURMANOVÁ, Katarína, Ludvig P MUREN, Oscar CASARES-MAGAZ, Vitali MOISEENKO, John P EINCK, Sara PILSKOG a Renata G RAIDOU. PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support. \textit{Computers \&{} Graphics}. Elsevier Science, 2021, roč.~97, April, s.~126-138. ISSN~0097-8493. Dostupné z: https://dx.doi.org/10.1016/j.cag.2021.04.010.
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