PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support

FURMANOVÁ, Katarína, Ludvig P MUREN, Oscar CASARES-MAGAZ, Vitali MOISEENKO, John P EINCK, Sara PILSKOG and Renata G RAIDOU. PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support. Computers & Graphics. Elsevier Science, 2021, vol. 97, April, p. 126-138. ISSN 0097-8493. Available from: https://dx.doi.org/10.1016/j.cag.2021.04.010.

Basic information

• Original name: PREVIS: Predictive visual analytics of anatomical variability for radiotherapy decision support
• Authors: FURMANOVÁ, Katarína (703 Slovakia, belonging to the institution), Ludvig P MUREN, Oscar CASARES-MAGAZ, Vitali MOISEENKO, John P EINCK, Sara PILSKOG and Renata G RAIDOU.
• Edition: Computers & Graphics, Elsevier Science, 2021, 0097-8493.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10200 1.2 Computer and information sciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.821
• RIV identification code: RIV/00216224:14330/21:00124927
• Organization unit: Faculty of Informatics
• Doi: http://dx.doi.org/10.1016/j.cag.2021.04.010
• UT WoS: 000661427000001
• Keywords in English: Medical Visualization; Visual Analytics; Comparative Visualization; Ensemble Visualization; Radiotherapy Planning; Cohort Study
• Tags: International impact, Reviewed

Abstract

Radiotherapy (RT) requires meticulous planning prior to treatment, where the RT plan is optimized with organ delineations on a pre-treatment Computed Tomography (CT) scan of the patient. The conventionally fractionated treatment usually lasts several weeks. Random changes (e.g., rectal and bladder filling in prostate cancer patients) and systematic changes (e.g., weight loss) occur while the patient is being treated. Therefore, the delivered dose distribution may deviate from the planned. Modern technology, in particular image guidance, allows to minimize these deviations, but risks for the patient remain. We present PREVIS: a visual analytics tool for (i) the exploration and prediction of changes in patient anatomy during the upcoming treatment, and (ii) the assessment of treatment strategies, with respect to the anticipated changes. Records of during-treatment changes from a retrospective imaging cohort with complete data are employed in PREVIS, to infer expected anatomical changes of new incoming patients with incomplete data, using a generative model. Abstracted representations of the retrospective cohort partitioning provide insight into an underlying automated clustering, showing main modes of variation for past patients. Interactive similarity representations support an informed selection of matching between new incoming patients and past patients. A Principal Component Analysis (PCA)-based generative model describes the predicted spatial probability distributions of the incoming patient’s organs in the upcoming weeks of treatment, based on observations of past patients. The generative model is interactively linked to treatment plan evaluation, supporting the selection of the optimal treatment strategy. We present a usage scenario, demonstrating the applicability of PREVIS in a clinical research setting, and we evaluate our visual analytics tool with eight clinical researchers.