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@article{1767998,
author = {Lipový, Břetislav and Holoubek, Jakub and Hanslianova, Marketa and Cvanová, Michaela and Klein, Leo and Grossova, Ivana and Zajicek, Robert and Bukovcan, Peter and Koller, Jan and Baran, Matus and Lengyel, Peter and Eimer, Lukas and Jandova, Marie and Kostal, Milan and Brychta, Pavel and Bořilová Linhartová, Petra},
article_location = {Basel},
article_number = {1},
doi = {http://dx.doi.org/10.3390/microorganisms9010202},
keywords = {toxic epidermal necrolysis; antibiotics; infectious complication; early-onset infection; late-onset infection},
language = {eng},
issn = {2076-2607},
journal = {Microorganisms},
title = {Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications},
url = {https://www.mdpi.com/2076-2607/9/1/202},
volume = {9},
year = {2021}
}
TY - JOUR
ID - 1767998
AU - Lipový, Břetislav - Holoubek, Jakub - Hanslianova, Marketa - Cvanová, Michaela - Klein, Leo - Grossova, Ivana - Zajicek, Robert - Bukovcan, Peter - Koller, Jan - Baran, Matus - Lengyel, Peter - Eimer, Lukas - Jandova, Marie - Kostal, Milan - Brychta, Pavel - Bořilová Linhartová, Petra
PY - 2021
TI - Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications
JF - Microorganisms
VL - 9
IS - 1
SP - 1-15
EP - 1-15
PB - MDPI
SN - 20762607
KW - toxic epidermal necrolysis
KW - antibiotics
KW - infectious complication
KW - early-onset infection
KW - late-onset infection
UR - https://www.mdpi.com/2076-2607/9/1/202
N2 - Toxic epidermal necrolysis (TEN) is a rare disease, which predominantly manifests as damage to the skin and mucosa. Antibiotics count among the most common triggers of this hypersensitive reaction. Patients with TEN are highly susceptible to infectious complications due to the loss of protective barriers and immunosuppressant therapy. The aim of this study was to investigate the potential relationship between antibiotics used before the development of TEN and early and late-onset infectious complications in TEN patients. In this European multicentric retrospective study (Central European Lyell syndrome: therapeutic evaluation (CELESTE)), records showed that 18 patients with TEN used antibiotics (mostly aminopenicillins) before the disease development (group 1), while in 21 patients, TEN was triggered by another factor (group 2). The incidence of late-onset infectious complications (5 or more days after the transfer to the hospital) caused by Gram-positive bacteria (especially by Enterococcus faecalis/faecium) was significantly higher in group 1 than in group 2 (82.4% vs. 35.0%, p = 0.007/p(corr) = 0.014) while no statistically significant difference was observed between groups of patients with infection caused by Gram-negative bacteria, yeasts, and filamentous fungi (p > 0.05). Patients with post-antibiotic development of TEN are critically predisposed to late-onset infectious complications caused by Gram-positive bacteria, which may result from the dissemination of these bacteria from the primary focus.
ER -
LIPOVÝ, Břetislav, Jakub HOLOUBEK, Marketa HANSLIANOVA, Michaela CVANOVÁ, Leo KLEIN, Ivana GROSSOVA, Robert ZAJICEK, Peter BUKOVCAN, Jan KOLLER, Matus BARAN, Peter LENGYEL, Lukas EIMER, Marie JANDOVA, Milan KOSTAL, Pavel BRYCHTA a Petra BOŘILOVÁ LINHARTOVÁ. Impact of Antibiotics Associated with the Development of Toxic Epidermal Necrolysis on Early and Late-Onset Infectious Complications. \textit{Microorganisms}. Basel: MDPI, roč.~9, č.~1, s.~1-15. ISSN~2076-2607. doi:10.3390/microorganisms9010202. 2021.
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