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@article{1776197,
author = {Hubacek, Jaroslav A. and Dušek, Ladislav and Májek, Ondřej and Adamek, Vaclav and Cervinkova, Tereza and Dlouha, Dana and Pavel, Jozef and Adamkova, Vera},
article_location = {Praha},
article_number = {1},
doi = {http://dx.doi.org/10.33549/physiolres.934647},
keywords = {COVID-19; CCR5; Polymorphism; Deletion; Delta 32},
language = {eng},
issn = {0862-8408},
journal = {Physiological research},
title = {CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects},
url = {https://www.biomed.cas.cz/physiolres/pdf/2021/70_111.pdf},
volume = {70},
year = {2021}
}
TY - JOUR
ID - 1776197
AU - Hubacek, Jaroslav A. - Dušek, Ladislav - Májek, Ondřej - Adamek, Vaclav - Cervinkova, Tereza - Dlouha, Dana - Pavel, Jozef - Adamkova, Vera
PY - 2021
TI - CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects
JF - Physiological research
VL - 70
IS - 1
SP - 111-115
EP - 111-115
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - COVID-19
KW - CCR5
KW - Polymorphism
KW - Deletion
KW - Delta 32
UR - https://www.biomed.cas.cz/physiolres/pdf/2021/70_111.pdf
N2 - Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), has spread widely around the globe. Significant inter-individual differences have been observed during the course of the infection, which suggests that genetic susceptibility may be a contributing factor. CC chemokine receptor 5 (CCR5), which acts as a co-receptor for the entry of HIV-1 into cells, is promising candidate whose can have an influence on SARS-CoV-2 infection. A genetic mutation known as CCR5 Delta 32, consisting of a 32-nucleotide deletion, encodes a truncated protein that protects homozygous carriers of the deletion from HIV-1 infection. Similarly, inhibition of CCR5 seems to be protective against COVID-19. In our study, we successfully genotyped 416 first-wave SARS-CoV-2-positive infection survivors (164 asymptomatic and 252 symptomatic) for CCR5 Delta 32, comparing them with a population based sample of 2,404 subjects. We found the highest number (P=0.03) of CCR5 Delta 32 carriers in SARS-CoV-2-positive/COVID-19-asymptomatic subjects (23.8 %) and the lowest number in SARS-CoV-2-positive/COVID-19-symptomatic patients (16.7 %), with frequency in the control population in the middle (21.0 %). We conclude that the CCR5 Delta 32 I/D polymorphism may have the potential to predict the severity of SARS-CoV-2 infection.
ER -
HUBACEK, Jaroslav A., Ladislav DUŠEK, Ondřej MÁJEK, Vaclav ADAMEK, Tereza CERVINKOVA, Dana DLOUHA, Jozef PAVEL and Vera ADAMKOVA. CCR5 Delta 32 Deletion as a Protective Factor in Czech First-Wave COVID-19 Subjects. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2021, vol.~70, No~1, p.~111-115. ISSN~0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.934647.
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