Prospective Cohort Study of Infective Endocarditis in People
Who Inject Drugs

J 2021

Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs

PERICAS, J. M., J. LLOPIS, E. ATHAN, M. HERNANDEZ-MENESES, M. M. HANNAN et. al.

Základní údaje

Originální název

Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs

Autoři

PERICAS, J. M., J. LLOPIS, E. ATHAN, M. HERNANDEZ-MENESES, M. M. HANNAN, D. R. MURDOCH, Z. KANAFANI, Tomáš FREIBERGER (203 Česká republika, domácí), J. STRAHILEVITZ, N. FERNANDEZ-HIDALGO, C. LAMAS, E. DURANTE-MANGONI, P. TATTEVIN, F. NACINOVICH, V. H. CHU a J. M. MIRO (garant)

Vydání

Journal of the American College of Cardiology, New York, Elsevier Science INC, 2021, 0735-1097

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 27.203

Kód RIV

RIV/00216224:14110/21:00121771

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jacc.2020.11.062

UT WoS

000631946500004

Klíčová slova anglicky

cardiac surgery; HIV; infective endocarditis; opioid crisis; people who inject drugs; Staphylococcus aureus

Štítky

14110114, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 12. 2022 09:24, Mgr. Tereza Miškechová

Anotace

V originále

BACKGROUND Infective endocarditis (IE) in people who inject drugs (PWID) is an emergent public health problem. OBJECTIVES The purpose of this study was to investigate IE in PWID and compare it with IE in non-PWID patients. METHODS Two prospective cohort studies (ICE-PCS and ICE-Plus databases, encompassing 8,112 IE episodes from 2000 to 2006 and 2008 to 2012, with 64 and 34 sites and 28 and 18 countries, respectively). Outcomes were compared between PWID and non-PWID patients with IE. Logistic regression analyses were performed to investigate risk factors for 6-month mortality and relapses amongst PWID. RESULTS A total of 7,616 patients (591 PWID and 7,025 non-PWID) were included. PWID patients were significantly younger (median 37.0 years [interquartile range: 29.5 to 44.2 years] vs. 63.3 years [interquartile range: 49.3 to 74.0 years]; p < 0.001), male (72.5% vs. 67.4%; p = 0.007), and presented lower rates of comorbidities except for human immunodeficiency virus, liver disease, and higher rates of prior IE. Amongst IE cases in PWID, 313 (53%) episodes involved left-side valves and 204 (34.5%) were purely left-sided IE. PWID presented a larger proportion of native IE (90.2% vs. 64.4%; p < 0.001), whereas prosthetic-IE and cardiovascular implantable electronic device-IE were more frequent in non-PWID (9.3% vs. 27.0% and 0.5% vs. 8.6%; both p < 0.001). Staphylococcus aureus caused 65.9% and 26.8% of cases in PWID and non-PWID, respectively (p < 0.001). PWID presented higher rates of systemic emboli (51.1% vs. 22.5%; p < 0.001) and persistent bacteremia (14.7% vs. 9.3%; p < 0.001). Cardiac surgery was less frequently performed (39.5% vs. 47.8%; p < 0.001), and in-hospital and 6-month mortality were lower in PWID (10.8% vs. 18.2% and 14.4% vs. 22.2%; both p < 0.001), whereas relapses were more frequent in PWID (9.5% vs. 2.8%; p < 0.001). Prior IE, left-sided IE, polymicrobial etiology, intracardiac complications, and stroke were risk factors for 6-month mortality, whereas cardiac surgery was associated with lower mortality in the PWID population. CONCLUSIONS A notable proportion of cases in PWID involve left-sided valves, prosthetic valves, or are caused by microorganisms other than S. aureus. (C) 2021 by the American College of Cardiology Foundation.

Citovat

PERICAS, J. M., J. LLOPIS, E. ATHAN, M. HERNANDEZ-MENESES, M. M. HANNAN, D. R. MURDOCH, Z. KANAFANI, Tomáš FREIBERGER, J. STRAHILEVITZ, N. FERNANDEZ-HIDALGO, C. LAMAS, E. DURANTE-MANGONI, P. TATTEVIN, F. NACINOVICH, V. H. CHU a J. M. MIRO. Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs. Journal of the American College of Cardiology. New York: Elsevier Science INC, 2021, roč. 77, č. 5, s. 544-555. ISSN 0735-1097. Dostupné z: https://dx.doi.org/10.1016/j.jacc.2020.11.062.

@article{1776200,
   author = {Pericas, J. M. and Llopis, J. and Athan, E. and HernandezandMeneses, M. and Hannan, M. M. and Murdoch, D. R. and Kanafani, Z. and Freiberger, Tomáš and Strahilevitz, J. and FernandezandHidalgo, N. and Lamas, C. and DuranteandMangoni, E. and Tattevin, P. and Nacinovich, F. and Chu, V. H. and Miro, J. M.},
   article_location = {New York},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.jacc.2020.11.062},
   keywords = {cardiac surgery; HIV; infective endocarditis; opioid crisis; people who inject drugs; Staphylococcus aureus},
   language = {eng},
   issn = {0735-1097},
   journal = {Journal of the American College of Cardiology},
   title = {Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs},
   url = {https://www.sciencedirect.com/science/article/pii/S0735109720380050?via%3Dihub},
   volume = {77},
   year = {2021}
}

TY  - JOUR
ID  - 1776200
AU  - Pericas, J. M. - Llopis, J. - Athan, E. - Hernandez-Meneses, M. - Hannan, M. M. - Murdoch, D. R. - Kanafani, Z. - Freiberger, Tomáš - Strahilevitz, J. - Fernandez-Hidalgo, N. - Lamas, C. - Durante-Mangoni, E. - Tattevin, P. - Nacinovich, F. - Chu, V. H. - Miro, J. M.
PY  - 2021
TI  - Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs
JF  - Journal of the American College of Cardiology
VL  - 77
IS  - 5
SP  - 544-555
EP  - 544-555
PB  - Elsevier Science INC
SN  - 07351097
KW  - cardiac surgery
KW  - HIV
KW  - infective endocarditis
KW  - opioid crisis
KW  - people who inject drugs
KW  - Staphylococcus aureus
UR  - https://www.sciencedirect.com/science/article/pii/S0735109720380050?via%3Dihub
N2  - BACKGROUND Infective endocarditis (IE) in people who inject drugs (PWID) is an emergent public health problem. OBJECTIVES The purpose of this study was to investigate IE in PWID and compare it with IE in non-PWID patients. METHODS Two prospective cohort studies (ICE-PCS and ICE-Plus databases, encompassing 8,112 IE episodes from 2000 to 2006 and 2008 to 2012, with 64 and 34 sites and 28 and 18 countries, respectively). Outcomes were compared between PWID and non-PWID patients with IE. Logistic regression analyses were performed to investigate risk factors for 6-month mortality and relapses amongst PWID. RESULTS A total of 7,616 patients (591 PWID and 7,025 non-PWID) were included. PWID patients were significantly younger (median 37.0 years [interquartile range: 29.5 to 44.2 years] vs. 63.3 years [interquartile range: 49.3 to 74.0 years]; p < 0.001), male (72.5% vs. 67.4%; p = 0.007), and presented lower rates of comorbidities except for human immunodeficiency virus, liver disease, and higher rates of prior IE. Amongst IE cases in PWID, 313 (53%) episodes involved left-side valves and 204 (34.5%) were purely left-sided IE. PWID presented a larger proportion of native IE (90.2% vs. 64.4%; p < 0.001), whereas prosthetic-IE and cardiovascular implantable electronic device-IE were more frequent in non-PWID (9.3% vs. 27.0% and 0.5% vs. 8.6%; both p < 0.001). Staphylococcus aureus caused 65.9% and 26.8% of cases in PWID and non-PWID, respectively (p < 0.001). PWID presented higher rates of systemic emboli (51.1% vs. 22.5%; p < 0.001) and persistent bacteremia (14.7% vs. 9.3%; p < 0.001). Cardiac surgery was less frequently performed (39.5% vs. 47.8%; p < 0.001), and in-hospital and 6-month mortality were lower in PWID (10.8% vs. 18.2% and 14.4% vs. 22.2%; both p < 0.001), whereas relapses were more frequent in PWID (9.5% vs. 2.8%; p < 0.001). Prior IE, left-sided IE, polymicrobial etiology, intracardiac complications, and stroke were risk factors for 6-month mortality, whereas cardiac surgery was associated with lower mortality in the PWID population. CONCLUSIONS A notable proportion of cases in PWID involve left-sided valves, prosthetic valves, or are caused by microorganisms other than S. aureus. (C) 2021 by the American College of Cardiology Foundation.
ER  -

PERICAS, J. M., J. LLOPIS, E. ATHAN, M. HERNANDEZ-MENESES, M. M. HANNAN, D. R. MURDOCH, Z. KANAFANI, Tomáš FREIBERGER, J. STRAHILEVITZ, N. FERNANDEZ-HIDALGO, C. LAMAS, E. DURANTE-MANGONI, P. TATTEVIN, F. NACINOVICH, V. H. CHU a J. M. MIRO. Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs. \textit{Journal of the American College of Cardiology}. New York: Elsevier Science INC, 2021, roč.~77, č.~5, s.~544-555. ISSN~0735-1097. Dostupné z: https://dx.doi.org/10.1016/j.jacc.2020.11.062.

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