HUBACEK, Jaroslav A., Ladislav DUŠEK, Ondřej MÁJEK, Vaclav ADAMEK, Tereza CERVINKOVA, Dana DLOUHA and Vera ADAMKOVA. ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors. Clinica Chimica Acta. AMSTERDAM: ELSEVIER SCIENCE BV, 2021, vol. 519, AUG 2021, p. 206-209. ISSN 0009-8981. Available from: https://dx.doi.org/10.1016/j.cca.2021.04.024.
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Basic information
Original name ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors
Authors HUBACEK, Jaroslav A. (203 Czech Republic, guarantor), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Ondřej MÁJEK (203 Czech Republic, belonging to the institution), Vaclav ADAMEK (203 Czech Republic), Tereza CERVINKOVA (203 Czech Republic), Dana DLOUHA (203 Czech Republic) and Vera ADAMKOVA (203 Czech Republic).
Edition Clinica Chimica Acta, AMSTERDAM, ELSEVIER SCIENCE BV, 2021, 0009-8981.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 20602 Medical laboratory technology ;
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 6.314
RIV identification code RIV/00216224:14110/21:00121855
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.cca.2021.04.024
UT WoS 000659205000008
Keywords in English COVID-19; ACE; Polymorphism; Insertion; deletion
Tags 14119612, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 28/6/2021 13:50.
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread from China in 2019/ 2020 to all continents. Significant geographical and ethnic differences were described, and host genetic background seems to be important for the resistance to and mortality of COVID-19. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4646994) is one of the candidates with the potential to affect infection symptoms and mortality. Methods: In our study, we successfully genotyped 408 SARS-CoV-2-positive COVID-19 survivors (163 asymptomatic and 245 symptomatic) and compared them with a population-based DNA bank of 2,559 subjects. Results: The frequency of ACE I/I homozygotes was significantly increased in COVID-19 patients compared with that in controls (26.2% vs. 21.2%; P = 0.02; OR [95% CI] = 1.55 [1.17-2.05]. Importantly, however, the difference was driven just by the symptomatic subjects (29.0% vs. 21.2% of the I/I homozygotes; P = 0.002; OR [95% CI] = 1.78 [1.22-2.60]). The genotype distribution of the ACE genotypes was almost identical in population controls and asymptomatic SARS-CoV-2-positive patients (P = 0.76). Conclusions: We conclude that ACE I/D polymorphism could have the potential to predict the severity of COVID19, with I/I homozygotes being at increased risk of symptomatic COVID-19.
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