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@article{1779177,
author = {Hubacek, Jaroslav A. and Dušek, Ladislav and Májek, Ondřej and Adamek, Vaclav and Cervinkova, Tereza and Dlouha, Dana and Adamkova, Vera},
article_location = {AMSTERDAM},
article_number = {AUG 2021},
doi = {http://dx.doi.org/10.1016/j.cca.2021.04.024},
keywords = {COVID-19; ACE; Polymorphism; Insertion; deletion},
language = {eng},
issn = {0009-8981},
journal = {Clinica Chimica Acta},
title = {ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors},
url = {https://www.sciencedirect.com/science/article/pii/S0009898121001492?via%3Dihub},
volume = {519},
year = {2021}
}
TY - JOUR
ID - 1779177
AU - Hubacek, Jaroslav A. - Dušek, Ladislav - Májek, Ondřej - Adamek, Vaclav - Cervinkova, Tereza - Dlouha, Dana - Adamkova, Vera
PY - 2021
TI - ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors
JF - Clinica Chimica Acta
VL - 519
IS - AUG 2021
SP - 206-209
EP - 206-209
PB - ELSEVIER SCIENCE BV
SN - 00098981
KW - COVID-19
KW - ACE
KW - Polymorphism
KW - Insertion
KW - deletion
UR - https://www.sciencedirect.com/science/article/pii/S0009898121001492?via%3Dihub
N2 - Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread from China in 2019/ 2020 to all continents. Significant geographical and ethnic differences were described, and host genetic background seems to be important for the resistance to and mortality of COVID-19. Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism (rs4646994) is one of the candidates with the potential to affect infection symptoms and mortality. Methods: In our study, we successfully genotyped 408 SARS-CoV-2-positive COVID-19 survivors (163 asymptomatic and 245 symptomatic) and compared them with a population-based DNA bank of 2,559 subjects. Results: The frequency of ACE I/I homozygotes was significantly increased in COVID-19 patients compared with that in controls (26.2% vs. 21.2%; P = 0.02; OR [95% CI] = 1.55 [1.17-2.05]. Importantly, however, the difference was driven just by the symptomatic subjects (29.0% vs. 21.2% of the I/I homozygotes; P = 0.002; OR [95% CI] = 1.78 [1.22-2.60]). The genotype distribution of the ACE genotypes was almost identical in population controls and asymptomatic SARS-CoV-2-positive patients (P = 0.76). Conclusions: We conclude that ACE I/D polymorphism could have the potential to predict the severity of COVID19, with I/I homozygotes being at increased risk of symptomatic COVID-19.
ER -
HUBACEK, Jaroslav A., Ladislav DUŠEK, Ondřej MÁJEK, Vaclav ADAMEK, Tereza CERVINKOVA, Dana DLOUHA a Vera ADAMKOVA. ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors. \textit{Clinica Chimica Acta}. AMSTERDAM: ELSEVIER SCIENCE BV, 2021, roč.~519, AUG 2021, s.~206-209. ISSN~0009-8981. Dostupné z: https://dx.doi.org/10.1016/j.cca.2021.04.024.
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