Thermal Ablation and Transarterial Chemoembolization are
Characterized by Changing Dynamics of Circulating MicroRNAs

J 2021

Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs

ANDRAŠINA, Tomáš; Jaroslav JURÁČEK; Jan ZAVADIL; Barbora ČECHOVÁ; Tomáš ROHAN et al.

Základní údaje

Originální název

Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs

Autoři

ANDRAŠINA, Tomáš; Jaroslav JURÁČEK; Jan ZAVADIL; Barbora ČECHOVÁ; Tomáš ROHAN; Petra VESELÁ ; Mor PALDOR; Ondřej SLABÝ a Nahum GOLDBERG

Vydání

Journal of vascular and interventional radiology, New York, Lippincott Williams & Wilkins, 2021, 1051-0443

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.682

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/21:00121875

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

EPITHELIAL-MESENCHYMAL TRANSITION; RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA; SERUM MICRORNA-210; CANCER; EXPRESSION; MECHANISM; GROWTH; PROGRESSION; METASTASIS

Štítky

14110216, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 8. 2024 08:12, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: To determine whether the levels of circulating microRNAs (miRNAs) are altered in patients undergoing thermal ablation and chemoembolization and whether these changes are predictive of a clinical outcome. Material and Methods: This prospective study consisted of 43 patients diagnosed with hepatocellular carcinoma (n = 15) and intrahepatic colorectal cancer metastases (n = 28) treated with thermal ablation (n = 23; radiofrequency [n = 6] or microwave [n = 19]), chemoembolization using drug-eluting embolics (n = 18), or both (n = 2). Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. Tumor burden and treatment response at 3 months were evaluated using the modified response evaluation criteria in solid tumors. The miRNA results were compared with clinical outcomes (Mann-Whitney U test, Wilcoxon matched-pair test). Results: Dynamic changes in the circulating miRNA levels were observed following both the interventions. For thermal ablation, significant increases in miR-21, miR-210, miR-122, miR-200a, and miR-34a concentrations peaked 60-90 minutes after the intervention (P < .01). However, for transarterial chemoembolization, maximum increases in the miRNA concentrations were observed at 24 hours after the intervention for miR-21, miR-210, miR-122, miR-200a, and miR-34a (P < .05). The increased concentrations of the circulating miRNAs were followed by a subsequent decline to baseline by 7 days. For the thermal ablation (but not chemoembolization) patients, elevations in the miR-210 and miR-200a levels were associated with early progressive disease at 3 months (P = .040 and P = .012, respectively). Conclusions: Increased but dynamic levels of circulating miRNAs are present following interventional oncologic procedures and may prove useful as biomarkers for the monitoring of clinical outcomes.

Návaznosti

MUNI/A/1488/2019, interní kód MU

Název: Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě onkologických pacientů

Investor: Masarykova univerzita, Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě onkologických pacientů, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

ANDRAŠINA, Tomáš; Jaroslav JURÁČEK; Jan ZAVADIL; Barbora ČECHOVÁ; Tomáš ROHAN; Petra VESELÁ; Mor PALDOR; Ondřej SLABÝ a Nahum GOLDBERG. Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs. Journal of vascular and interventional radiology. New York: Lippincott Williams & Wilkins, 2021, roč. 32, č. 3, s. 403-411. ISSN 1051-0443. Dostupné z: https://doi.org/10.1016/j.jvir.2020.10.024.

@article{1780439,
   author = {Andrašina, Tomáš and Juráček, Jaroslav and Zavadil, Jan and Čechová, Barbora and Rohan, Tomáš and Veselá, Petra and Paldor, Mor and Slabý, Ondřej and Goldberg, Nahum},
   article_location = {New York},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.jvir.2020.10.024},
   keywords = {EPITHELIAL-MESENCHYMAL TRANSITION; RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA; SERUM MICRORNA-210; CANCER; EXPRESSION; MECHANISM; GROWTH; PROGRESSION; METASTASIS},
   language = {eng},
   issn = {1051-0443},
   journal = {Journal of vascular and interventional radiology},
   title = {Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs},
   url = {https://www.sciencedirect.com/science/article/pii/S1051044320309532},
   volume = {32},
   year = {2021}
}

TY  - JOUR
ID  - 1780439
AU  - Andrašina, Tomáš - Juráček, Jaroslav - Zavadil, Jan - Čechová, Barbora - Rohan, Tomáš - Veselá, Petra - Paldor, Mor - Slabý, Ondřej - Goldberg, Nahum
PY  - 2021
TI  - Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs
JF  - Journal of vascular and interventional radiology
VL  - 32
IS  - 3
SP  - 403-411
EP  - 403-411
PB  - Lippincott Williams & Wilkins
SN  - 10510443
KW  - EPITHELIAL-MESENCHYMAL TRANSITION
KW  - RADIOFREQUENCY ABLATION
KW  - HEPATOCELLULAR-CARCINOMA
KW  - SERUM MICRORNA-210
KW  - CANCER
KW  - EXPRESSION
KW  - MECHANISM
KW  - GROWTH
KW  - PROGRESSION
KW  - METASTASIS
UR  - https://www.sciencedirect.com/science/article/pii/S1051044320309532
N2  - Purpose: To determine whether the levels of circulating microRNAs (miRNAs) are altered in patients undergoing thermal ablation and chemoembolization and whether these changes are predictive of a clinical outcome. Material and Methods: This prospective study consisted of 43 patients diagnosed with hepatocellular carcinoma (n = 15) and intrahepatic colorectal cancer metastases (n = 28) treated with thermal ablation (n = 23; radiofrequency [n = 6] or microwave [n = 19]), chemoembolization using drug-eluting embolics (n = 18), or both (n = 2). Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. Tumor burden and treatment response at 3 months were evaluated using the modified response evaluation criteria in solid tumors. The miRNA results were compared with clinical outcomes (Mann-Whitney U test, Wilcoxon matched-pair test). Results: Dynamic changes in the circulating miRNA levels were observed following both the interventions. For thermal ablation, significant increases in miR-21, miR-210, miR-122, miR-200a, and miR-34a concentrations peaked 60-90 minutes after the intervention (P < .01). However, for transarterial chemoembolization, maximum increases in the miRNA concentrations were observed at 24 hours after the intervention for miR-21, miR-210, miR-122, miR-200a, and miR-34a (P < .05). The increased concentrations of the circulating miRNAs were followed by a subsequent decline to baseline by 7 days. For the thermal ablation (but not chemoembolization) patients, elevations in the miR-210 and miR-200a levels were associated with early progressive disease at 3 months (P = .040 and P = .012, respectively). Conclusions: Increased but dynamic levels of circulating miRNAs are present following interventional oncologic procedures and may prove useful as biomarkers for the monitoring of clinical outcomes.
ER  -

ANDRAŠINA, Tomáš; Jaroslav JURÁČEK; Jan ZAVADIL; Barbora ČECHOVÁ; Tomáš ROHAN; Petra VESELÁ; Mor PALDOR; Ondřej SLABÝ a Nahum GOLDBERG. Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs. \textit{Journal of vascular and interventional radiology}. New York: Lippincott Williams \&{} Wilkins, 2021, roč.~32, č.~3, s.~403-411. ISSN~1051-0443. Dostupné z: https://doi.org/10.1016/j.jvir.2020.10.024.

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