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@article{1780439, author = {Andrašina, Tomáš and Juráček, Jaroslav and Zavadil, Jan and Čechová, Barbora and Rohan, Tomáš and Veselá, Petra and Paldor, Mor and Slabý, Ondřej and Goldberg, Nahum}, article_location = {New York}, article_number = {3}, doi = {http://dx.doi.org/10.1016/j.jvir.2020.10.024}, keywords = {EPITHELIAL-MESENCHYMAL TRANSITION; RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA; SERUM MICRORNA-210; CANCER; EXPRESSION; MECHANISM; GROWTH; PROGRESSION; METASTASIS}, language = {eng}, issn = {1051-0443}, journal = {Journal of vascular and interventional radiology}, title = {Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs}, url = {https://www.sciencedirect.com/science/article/pii/S1051044320309532}, volume = {32}, year = {2021} }
TY - JOUR ID - 1780439 AU - Andrašina, Tomáš - Juráček, Jaroslav - Zavadil, Jan - Čechová, Barbora - Rohan, Tomáš - Veselá, Petra - Paldor, Mor - Slabý, Ondřej - Goldberg, Nahum PY - 2021 TI - Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs JF - Journal of vascular and interventional radiology VL - 32 IS - 3 SP - 403-411 EP - 403-411 PB - Lippincott Williams & Wilkins SN - 10510443 KW - EPITHELIAL-MESENCHYMAL TRANSITION KW - RADIOFREQUENCY ABLATION KW - HEPATOCELLULAR-CARCINOMA KW - SERUM MICRORNA-210 KW - CANCER KW - EXPRESSION KW - MECHANISM KW - GROWTH KW - PROGRESSION KW - METASTASIS UR - https://www.sciencedirect.com/science/article/pii/S1051044320309532 N2 - Purpose: To determine whether the levels of circulating microRNAs (miRNAs) are altered in patients undergoing thermal ablation and chemoembolization and whether these changes are predictive of a clinical outcome. Material and Methods: This prospective study consisted of 43 patients diagnosed with hepatocellular carcinoma (n = 15) and intrahepatic colorectal cancer metastases (n = 28) treated with thermal ablation (n = 23; radiofrequency [n = 6] or microwave [n = 19]), chemoembolization using drug-eluting embolics (n = 18), or both (n = 2). Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. Tumor burden and treatment response at 3 months were evaluated using the modified response evaluation criteria in solid tumors. The miRNA results were compared with clinical outcomes (Mann-Whitney U test, Wilcoxon matched-pair test). Results: Dynamic changes in the circulating miRNA levels were observed following both the interventions. For thermal ablation, significant increases in miR-21, miR-210, miR-122, miR-200a, and miR-34a concentrations peaked 60-90 minutes after the intervention (P < .01). However, for transarterial chemoembolization, maximum increases in the miRNA concentrations were observed at 24 hours after the intervention for miR-21, miR-210, miR-122, miR-200a, and miR-34a (P < .05). The increased concentrations of the circulating miRNAs were followed by a subsequent decline to baseline by 7 days. For the thermal ablation (but not chemoembolization) patients, elevations in the miR-210 and miR-200a levels were associated with early progressive disease at 3 months (P = .040 and P = .012, respectively). Conclusions: Increased but dynamic levels of circulating miRNAs are present following interventional oncologic procedures and may prove useful as biomarkers for the monitoring of clinical outcomes. ER -
ANDRAŠINA, Tomáš, Jaroslav JURÁČEK, Jan ZAVADIL, Barbora ČECHOVÁ, Tomáš ROHAN, Petra VESELÁ, Mor PALDOR, Ondřej SLABÝ a Nahum GOLDBERG. Thermal Ablation and Transarterial Chemoembolization are Characterized by Changing Dynamics of Circulating MicroRNAs. \textit{Journal of vascular and interventional radiology}. New York: Lippincott Williams \&{} Wilkins, 2021, roč.~32, č.~3, s.~403-411. ISSN~1051-0443. Dostupné z: https://dx.doi.org/10.1016/j.jvir.2020.10.024.
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