Improvement of the Diagnosis of Isoattenuating Pancreatic
Carcinomas by Defining Their Characteristics on Contrast
Enhanced Computed Tomography and Endosonography with
Fine-Needle Aspiration (EUS-FNA)

J 2021

Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)

PSÁR, Robert; Ondřej URBAN; Marie ČERNÁ; Tomáš ROHAN; Martin HILL et al.

Základní údaje

Originální název

Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)

Autoři

PSÁR, Robert; Ondřej URBAN; Marie ČERNÁ; Tomáš ROHAN a Martin HILL

Vydání

Diagnostics, Švýcarsko, MDPI, 2021, 2075-4418

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.992

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/21:00121876

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

computed tomography; early diagnosis; endoscopic ultrasound-guided fine needle aspiration; isoattenuation; pancreatic carcinoma

Štítky

14110216, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 8. 2021 08:28, Mgr. Tereza Miškechová

Anotace

V originále

(1) Background. The aim was to define typical features of isoattenuating pancreatic carcinomas on computed tomography (CT) and endosonography and determine the yield of fine-needle aspiration endosonography (EUS-FNA) in their diagnosis. (2) Methods. One hundred and seventy-three patients with pancreatic carcinomas underwent multiphase contrast-enhanced CT followed by EUS-FNA at the time of diagnosis. Secondary signs on CT, size and location on EUS, and the yield of EUS-FNA in isoattenuating and hypoattenuating pancreatic cancer, were evaluated. (3) Results. Isoattenuating pancreatic carcinomas occurred in 12.1% of patients. Secondary signs of isoattenuating pancreatic carcinomas on CT were present in 95.2% cases and included dilatation of the pancreatic duct and/or the common bile duct (85.7%), interruption of the pancreatic duct (76.2%), abnormal pancreatic contour (33.3%), and atrophy of the distal parenchyma (9.5%) Compared to hypoattenuating pancreatic carcinomas, isoattenuating carcinomas were more often localized in the pancreatic head (100% vs. 59.2%; p < 0.001). In ROC (receiver operating characteristic) analysis, the optimal cut-off value for the size of isoattenuating carcinomas on EUS was <= 25 mm (AUC = 0.898). The sensitivity of EUS-FNA in confirmation of isoattenuating and hypoattenuating pancreatic cancer were 90.5% and 92.8% (p = 0.886). (4) Conclusions. Isoattenuating pancreatic head carcinoma can be revealed by indirect signs on CT and confirmed with high sensitivity by EUS-FNA.

Citovat

PSÁR, Robert; Ondřej URBAN; Marie ČERNÁ; Tomáš ROHAN a Martin HILL. Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA). Diagnostics. Švýcarsko: MDPI, 2021, roč. 11, č. 5, s. 1-11. ISSN 2075-4418. Dostupné z: https://doi.org/10.3390/diagnostics11050776.

@article{1780443,
   author = {Psár, Robert and Urban, Ondřej and Černá, Marie and Rohan, Tomáš and Hill, Martin},
   article_location = {Švýcarsko},
   article_number = {5},
   doi = {https://doi.org/10.3390/diagnostics11050776},
   keywords = {computed tomography; early diagnosis; endoscopic ultrasound-guided fine needle aspiration; isoattenuation; pancreatic carcinoma},
   language = {eng},
   issn = {2075-4418},
   journal = {Diagnostics},
   title = {Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)},
   url = {https://www.mdpi.com/2075-4418/11/5/776/htm},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1780443
AU  - Psár, Robert - Urban, Ondřej - Černá, Marie - Rohan, Tomáš - Hill, Martin
PY  - 2021
TI  - Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)
JF  - Diagnostics
VL  - 11
IS  - 5
SP  - 1-11
EP  - 1-11
PB  - MDPI
SN  - 20754418
KW  - computed tomography
KW  - early diagnosis
KW  - endoscopic ultrasound-guided fine needle aspiration
KW  - isoattenuation
KW  - pancreatic carcinoma
UR  - https://www.mdpi.com/2075-4418/11/5/776/htm
N2  - (1) Background. The aim was to define typical features of isoattenuating pancreatic carcinomas on computed tomography (CT) and endosonography and determine the yield of fine-needle aspiration endosonography (EUS-FNA) in their diagnosis. (2) Methods. One hundred and seventy-three patients with pancreatic carcinomas underwent multiphase contrast-enhanced CT followed by EUS-FNA at the time of diagnosis. Secondary signs on CT, size and location on EUS, and the yield of EUS-FNA in isoattenuating and hypoattenuating pancreatic cancer, were evaluated. (3) Results. Isoattenuating pancreatic carcinomas occurred in 12.1% of patients. Secondary signs of isoattenuating pancreatic carcinomas on CT were present in 95.2% cases and included dilatation of the pancreatic duct and/or the common bile duct (85.7%), interruption of the pancreatic duct (76.2%), abnormal pancreatic contour (33.3%), and atrophy of the distal parenchyma (9.5%) Compared to hypoattenuating pancreatic carcinomas, isoattenuating carcinomas were more often localized in the pancreatic head (100% vs. 59.2%; p < 0.001). In ROC (receiver operating characteristic) analysis, the optimal cut-off value for the size of isoattenuating carcinomas on EUS was <= 25 mm (AUC = 0.898). The sensitivity of EUS-FNA in confirmation of isoattenuating and hypoattenuating pancreatic cancer were 90.5% and 92.8% (p = 0.886). (4) Conclusions. Isoattenuating pancreatic head carcinoma can be revealed by indirect signs on CT and confirmed with high sensitivity by EUS-FNA.
ER  -

PSÁR, Robert; Ondřej URBAN; Marie ČERNÁ; Tomáš ROHAN a Martin HILL. Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA). \textit{Diagnostics}. Švýcarsko: MDPI, 2021, roč.~11, č.~5, s.~1-11. ISSN~2075-4418. Dostupné z: https://doi.org/10.3390/diagnostics11050776.

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