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@article{1780443,
author = {Psár, Robert and Urban, Ondřej and Černá, Marie and Rohan, Tomáš and Hill, Martin},
article_location = {Švýcarsko},
article_number = {5},
doi = {http://dx.doi.org/10.3390/diagnostics11050776},
keywords = {computed tomography; early diagnosis; endoscopic ultrasound-guided fine needle aspiration; isoattenuation; pancreatic carcinoma},
language = {eng},
issn = {2075-4418},
journal = {Diagnostics},
title = {Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)},
url = {https://www.mdpi.com/2075-4418/11/5/776/htm},
volume = {11},
year = {2021}
}
TY - JOUR
ID - 1780443
AU - Psár, Robert - Urban, Ondřej - Černá, Marie - Rohan, Tomáš - Hill, Martin
PY - 2021
TI - Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)
JF - Diagnostics
VL - 11
IS - 5
SP - 1-11
EP - 1-11
PB - MDPI
SN - 20754418
KW - computed tomography
KW - early diagnosis
KW - endoscopic ultrasound-guided fine needle aspiration
KW - isoattenuation
KW - pancreatic carcinoma
UR - https://www.mdpi.com/2075-4418/11/5/776/htm
N2 - (1) Background. The aim was to define typical features of isoattenuating pancreatic carcinomas on computed tomography (CT) and endosonography and determine the yield of fine-needle aspiration endosonography (EUS-FNA) in their diagnosis. (2) Methods. One hundred and seventy-three patients with pancreatic carcinomas underwent multiphase contrast-enhanced CT followed by EUS-FNA at the time of diagnosis. Secondary signs on CT, size and location on EUS, and the yield of EUS-FNA in isoattenuating and hypoattenuating pancreatic cancer, were evaluated. (3) Results. Isoattenuating pancreatic carcinomas occurred in 12.1% of patients. Secondary signs of isoattenuating pancreatic carcinomas on CT were present in 95.2% cases and included dilatation of the pancreatic duct and/or the common bile duct (85.7%), interruption of the pancreatic duct (76.2%), abnormal pancreatic contour (33.3%), and atrophy of the distal parenchyma (9.5%) Compared to hypoattenuating pancreatic carcinomas, isoattenuating carcinomas were more often localized in the pancreatic head (100% vs. 59.2%; p < 0.001). In ROC (receiver operating characteristic) analysis, the optimal cut-off value for the size of isoattenuating carcinomas on EUS was <= 25 mm (AUC = 0.898). The sensitivity of EUS-FNA in confirmation of isoattenuating and hypoattenuating pancreatic cancer were 90.5% and 92.8% (p = 0.886). (4) Conclusions. Isoattenuating pancreatic head carcinoma can be revealed by indirect signs on CT and confirmed with high sensitivity by EUS-FNA.
ER -
PSÁR, Robert, Ondřej URBAN, Marie ČERNÁ, Tomáš ROHAN a Martin HILL. Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA). \textit{Diagnostics}. Švýcarsko: MDPI, 2021, roč.~11, č.~5, s.~1-11. ISSN~2075-4418. Dostupné z: https://dx.doi.org/10.3390/diagnostics11050776.
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