Improvement of the Diagnosis of Isoattenuating Pancreatic
Carcinomas by Defining Their Characteristics on Contrast
Enhanced Computed Tomography and Endosonography with
Fine-Needle Aspiration (EUS-FNA)

J 2021

Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)

PSÁR, Robert, Ondřej URBAN, Marie ČERNÁ, Tomáš ROHAN, Martin HILL et. al.

Základní údaje

Originální název

Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)

Autoři

PSÁR, Robert (203 Česká republika, garant), Ondřej URBAN (203 Česká republika), Marie ČERNÁ (203 Česká republika), Tomáš ROHAN (203 Česká republika, domácí) a Martin HILL (203 Česká republika)

Vydání

Diagnostics, Švýcarsko, MDPI, 2021, 2075-4418

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.992

Kód RIV

RIV/00216224:14110/21:00121876

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/diagnostics11050776

UT WoS

000653806900001

Klíčová slova anglicky

computed tomography; early diagnosis; endoscopic ultrasound-guided fine needle aspiration; isoattenuation; pancreatic carcinoma

Štítky

14110216, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 8. 2021 08:28, Mgr. Tereza Miškechová

Anotace

V originále

(1) Background. The aim was to define typical features of isoattenuating pancreatic carcinomas on computed tomography (CT) and endosonography and determine the yield of fine-needle aspiration endosonography (EUS-FNA) in their diagnosis. (2) Methods. One hundred and seventy-three patients with pancreatic carcinomas underwent multiphase contrast-enhanced CT followed by EUS-FNA at the time of diagnosis. Secondary signs on CT, size and location on EUS, and the yield of EUS-FNA in isoattenuating and hypoattenuating pancreatic cancer, were evaluated. (3) Results. Isoattenuating pancreatic carcinomas occurred in 12.1% of patients. Secondary signs of isoattenuating pancreatic carcinomas on CT were present in 95.2% cases and included dilatation of the pancreatic duct and/or the common bile duct (85.7%), interruption of the pancreatic duct (76.2%), abnormal pancreatic contour (33.3%), and atrophy of the distal parenchyma (9.5%) Compared to hypoattenuating pancreatic carcinomas, isoattenuating carcinomas were more often localized in the pancreatic head (100% vs. 59.2%; p < 0.001). In ROC (receiver operating characteristic) analysis, the optimal cut-off value for the size of isoattenuating carcinomas on EUS was <= 25 mm (AUC = 0.898). The sensitivity of EUS-FNA in confirmation of isoattenuating and hypoattenuating pancreatic cancer were 90.5% and 92.8% (p = 0.886). (4) Conclusions. Isoattenuating pancreatic head carcinoma can be revealed by indirect signs on CT and confirmed with high sensitivity by EUS-FNA.

Citovat

PSÁR, Robert, Ondřej URBAN, Marie ČERNÁ, Tomáš ROHAN a Martin HILL. Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA). Diagnostics. Švýcarsko: MDPI, 2021, roč. 11, č. 5, s. 1-11. ISSN 2075-4418. Dostupné z: https://dx.doi.org/10.3390/diagnostics11050776.

@article{1780443,
   author = {Psár, Robert and Urban, Ondřej and Černá, Marie and Rohan, Tomáš and Hill, Martin},
   article_location = {Švýcarsko},
   article_number = {5},
   doi = {http://dx.doi.org/10.3390/diagnostics11050776},
   keywords = {computed tomography; early diagnosis; endoscopic ultrasound-guided fine needle aspiration; isoattenuation; pancreatic carcinoma},
   language = {eng},
   issn = {2075-4418},
   journal = {Diagnostics},
   title = {Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)},
   url = {https://www.mdpi.com/2075-4418/11/5/776/htm},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1780443
AU  - Psár, Robert - Urban, Ondřej - Černá, Marie - Rohan, Tomáš - Hill, Martin
PY  - 2021
TI  - Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA)
JF  - Diagnostics
VL  - 11
IS  - 5
SP  - 1-11
EP  - 1-11
PB  - MDPI
SN  - 20754418
KW  - computed tomography
KW  - early diagnosis
KW  - endoscopic ultrasound-guided fine needle aspiration
KW  - isoattenuation
KW  - pancreatic carcinoma
UR  - https://www.mdpi.com/2075-4418/11/5/776/htm
N2  - (1) Background. The aim was to define typical features of isoattenuating pancreatic carcinomas on computed tomography (CT) and endosonography and determine the yield of fine-needle aspiration endosonography (EUS-FNA) in their diagnosis. (2) Methods. One hundred and seventy-three patients with pancreatic carcinomas underwent multiphase contrast-enhanced CT followed by EUS-FNA at the time of diagnosis. Secondary signs on CT, size and location on EUS, and the yield of EUS-FNA in isoattenuating and hypoattenuating pancreatic cancer, were evaluated. (3) Results. Isoattenuating pancreatic carcinomas occurred in 12.1% of patients. Secondary signs of isoattenuating pancreatic carcinomas on CT were present in 95.2% cases and included dilatation of the pancreatic duct and/or the common bile duct (85.7%), interruption of the pancreatic duct (76.2%), abnormal pancreatic contour (33.3%), and atrophy of the distal parenchyma (9.5%) Compared to hypoattenuating pancreatic carcinomas, isoattenuating carcinomas were more often localized in the pancreatic head (100% vs. 59.2%; p < 0.001). In ROC (receiver operating characteristic) analysis, the optimal cut-off value for the size of isoattenuating carcinomas on EUS was <= 25 mm (AUC = 0.898). The sensitivity of EUS-FNA in confirmation of isoattenuating and hypoattenuating pancreatic cancer were 90.5% and 92.8% (p = 0.886). (4) Conclusions. Isoattenuating pancreatic head carcinoma can be revealed by indirect signs on CT and confirmed with high sensitivity by EUS-FNA.
ER  -

PSÁR, Robert, Ondřej URBAN, Marie ČERNÁ, Tomáš ROHAN a Martin HILL. Improvement of the Diagnosis of Isoattenuating Pancreatic Carcinomas by Defining Their Characteristics on Contrast Enhanced Computed Tomography and Endosonography with Fine-Needle Aspiration (EUS-FNA). \textit{Diagnostics}. Švýcarsko: MDPI, 2021, roč.~11, č.~5, s.~1-11. ISSN~2075-4418. Dostupné z: https://dx.doi.org/10.3390/diagnostics11050776.

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