Comparison of Four Bowel Cleansing Agents for Colonoscopy and
the Factors Affecting their Efficacy. A Prospective, Randomized
Study

J 2021

Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study

KMOCHOVA, Klara; Tomas GREGA; Ondřej NGO; Gabriela VOJTECHOVA; Ondřej MÁJEK et. al.

Základní údaje

Originální název

Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study

Autoři

KMOCHOVA, Klara (56 Belgie); Tomas GREGA (203 Česká republika); Ondřej NGO (203 Česká republika, domácí); Gabriela VOJTECHOVA (203 Česká republika); Ondřej MÁJEK (203 Česká republika, domácí); Petr URBANEK (203 Česká republika); Miroslav ZAVORAL (203 Česká republika) a Stepan SUCHANEK (203 Česká republika, garant)

Vydání

Journal of Gastrointestinal and Liver Diseases, CLUJ-NAPOCA, MEDICAL UNIV PRESS, 2021, 1841-8724

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Rumunsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.142

Kód RIV

RIV/00216224:14110/21:00120113

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.15403/jgld-3401

UT WoS

000663559800009

EID Scopus

2-s2.0-85105959446

Klíčová slova anglicky

bowel preparation; cleansing agents; colonoscopy; quality of colonoscopy; screening; polyp detection rate

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 7. 2021 15:00, Mgr. Tereza Miškechová

Anotace

V originále

Background & Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the efficacy of four different bowel cleansing agents. Methods: A single-center, prospective, randomized, and single-blind study was performed. Consecutive patients referred for colonoscopy were enrolled and randomized into one of the following types of laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were polyp detection rate (PDR) and tolerability. Results: Final analysis was performed on 431 patients. The number of patients with adequate bowel preparation (BBPS total scores >= 6 and sub scores >= 2 in each segment) was not significantly different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% MCSP; p=0.955). Excellent bowel preparation (BBPS total scores >= 8) was associated with younger age (p=0.007). The groups did not have significantly different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The strongest predictors of pathology identification were age and male gender. The best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024). Conclusion: All tested laxatives provided comparable efficacy in terms of bowel cleansing quality and PDR. The low-volume agent MCSP was the best tolerated.

Návaznosti

NV16-29614A, projekt VaV

Název: Porovnání účinnosti kolonické kapslové endoskopie a optické kolonoskopie u osob s pozitivním imunochemickým testem na okultní krvácení do stolice

NV17-31909A, projekt VaV

Název: Vývoj multiparametrického testu nové generace pro predikci rizika rekurence kolorektální neoplázie

NV18-08-00246, projekt VaV

Název: Endoskopická transmurální resekce versus standardní endoskopická terapie v léčbě kolorektální neoplázie – prospektivní randomizovaná studie

Investor: Ministerstvo zdravotnictví ČR, Endoskopická transmurální resekce versus standardní endoskopická terapie v léčbě kolorektální neoplázie – prospektivní randomizovaná studie

Citovat

KMOCHOVA, Klara; Tomas GREGA; Ondřej NGO; Gabriela VOJTECHOVA; Ondřej MÁJEK; Petr URBANEK; Miroslav ZAVORAL a Stepan SUCHANEK. Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study. Journal of Gastrointestinal and Liver Diseases. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, roč. 30, č. 2, s. 213-220. ISSN 1841-8724. Dostupné z: https://doi.org/10.15403/jgld-3401.

@article{1783548,
   author = {Kmochova, Klara and Grega, Tomas and Ngo, Ondřej and Vojtechova, Gabriela and Májek, Ondřej and Urbanek, Petr and Zavoral, Miroslav and Suchanek, Stepan},
   article_location = {CLUJ-NAPOCA},
   article_number = {2},
   doi = {https://doi.org/10.15403/jgld-3401},
   keywords = {bowel preparation; cleansing agents; colonoscopy; quality of colonoscopy; screening; polyp detection rate},
   language = {eng},
   issn = {1841-8724},
   journal = {Journal of Gastrointestinal and Liver Diseases},
   title = {Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study},
   url = {https://www.jgld.ro/jgld/index.php/jgld/article/view/3401},
   volume = {30},
   year = {2021}
}

TY  - JOUR
ID  - 1783548
AU  - Kmochova, Klara - Grega, Tomas - Ngo, Ondřej - Vojtechova, Gabriela - Májek, Ondřej - Urbanek, Petr - Zavoral, Miroslav - Suchanek, Stepan
PY  - 2021
TI  - Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study
JF  - Journal of Gastrointestinal and Liver Diseases
VL  - 30
IS  - 2
SP  - 213-220
EP  - 213-220
PB  - MEDICAL UNIV PRESS
SN  - 18418724
KW  - bowel preparation
KW  - cleansing agents
KW  - colonoscopy
KW  - quality of colonoscopy
KW  - screening
KW  - polyp detection rate
UR  - https://www.jgld.ro/jgld/index.php/jgld/article/view/3401
N2  - Background & Aims: Adequate bowel preparation is essential for successful and effective colonoscopy. Several types of cleansing agents are currently available including low-volume solutions. The aim of this study was to compare the efficacy of four different bowel cleansing agents. Methods: A single-center, prospective, randomized, and single-blind study was performed. Consecutive patients referred for colonoscopy were enrolled and randomized into one of the following types of laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were polyp detection rate (PDR) and tolerability. Results: Final analysis was performed on 431 patients. The number of patients with adequate bowel preparation (BBPS total scores >= 6 and sub scores >= 2 in each segment) was not significantly different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% MCSP; p=0.955). Excellent bowel preparation (BBPS total scores >= 8) was associated with younger age (p=0.007). The groups did not have significantly different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The strongest predictors of pathology identification were age and male gender. The best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024). Conclusion: All tested laxatives provided comparable efficacy in terms of bowel cleansing quality and PDR. The low-volume agent MCSP was the best tolerated.
ER  -

KMOCHOVA, Klara; Tomas GREGA; Ondřej NGO; Gabriela VOJTECHOVA; Ondřej MÁJEK; Petr URBANEK; Miroslav ZAVORAL a Stepan SUCHANEK. Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study. \textit{Journal of Gastrointestinal and Liver Diseases}. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, roč.~30, č.~2, s.~213-220. ISSN~1841-8724. Dostupné z: https://doi.org/10.15403/jgld-3401.

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