| HOLICKÁ, Martina, Jan MUSELÍK, Kateřina KUBOVÁ, Veronika DEÁKOVÁ, Sylvie PAVLOKOVÁ, Miroslava PAVELKOVÁ, Josef MAŠEK, David VETCHÝ a Jakub VYSLOUŽIL. Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles. Česká a slovenská farmacie. Česká lékařská společnost J.E. Purkyně, 2021, roč. 70, č. 1, s. 32-40. ISSN 1210-7816. |
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@article{1784099,
author = {Holická, Martina and Muselík, Jan and Kubová, Kateřina and Deáková, Veronika and Pavloková, Sylvie and Pavelková, Miroslava and Mašek, Josef and Vetchý, David and Vysloužil, Jakub},
article_number = {1},
keywords = {microparticles; solvent evaporation; PLGA; ibuprofen; size reduction},
language = {eng},
issn = {1210-7816},
journal = {Česká a slovenská farmacie},
title = {Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles},
url = {https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-1-22/vliv-zpusobu-emulgace-rychlosti-michani-a-objemu-na-plga-mikrocastice-s-ibuprofenem-126748},
volume = {70},
year = {2021}
}
TY - JOUR
ID - 1784099
AU - Holická, Martina - Muselík, Jan - Kubová, Kateřina - Deáková, Veronika - Pavloková, Sylvie - Pavelková, Miroslava - Mašek, Josef - Vetchý, David - Vysloužil, Jakub
PY - 2021
TI - Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles
JF - Česká a slovenská farmacie
VL - 70
IS - 1
SP - 32-40
EP - 32-40
PB - Česká lékařská společnost J.E. Purkyně
SN - 12107816
KW - microparticles
KW - solvent evaporation
KW - PLGA
KW - ibuprofen
KW - size reduction
UR - https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2021-1-22/vliv-zpusobu-emulgace-rychlosti-michani-a-objemu-na-plga-mikrocastice-s-ibuprofenem-126748
N2 - Microparticles based on biodegradable synthetic lactic acid and glycolic acid copolymer (PLGA) were successfully prepared by the solvent evaporation method. Ibuprofen was chosen as the model drug. Various formulation and process parameters have been used to prepare each sample with emphasis on size reduction. The effect of the emulsification method (direct emulsification or emulsification using an ULTRATURRAX or a NE-1000 dispenser), the volume of the aqueous phase (200, 800 ml) and the stirring speed of the emulsion system (600, 1000 rpm) on the characteristic properties of microparticles, such as encapsulation efficiency, drug loading and particle morphology, was observed. The resulting microparticles were evaluated by optical microscopy or laser diffraction and the dissolution test was performed. It was found that the sample prepared by direct emulsification with 800 ml of an aqueous phase at 600 rpm provided the most favorable results, meanwhile the emulsification prestep using a homogenizer caused promising particle size reduction. Gradual emulsification was evaluated as inapplicable due to great losses.
ER -
HOLICKÁ, Martina, Jan MUSELÍK, Kateřina KUBOVÁ, Veronika DEÁKOVÁ, Sylvie PAVLOKOVÁ, Miroslava PAVELKOVÁ, Josef MAŠEK, David VETCHÝ a Jakub VYSLOUŽIL. Influence of emulsification mode, stirring speed and volume on ibuprofen-loaded PLGA microparticles. \textit{Česká a slovenská farmacie}. Česká lékařská společnost J.E. Purkyně, 2021, roč.~70, č.~1, s.~32-40. ISSN~1210-7816.
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