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@article{1784539,
author = {Vinklerová, Petra and Bednaříková, Markéta and Minář, Luboš and Felsinger, Michal and Hausnerová, Jitka and Ovesná, Petra and Weinberger, Vít},
article_location = {Basel},
article_number = {7},
doi = {http://dx.doi.org/10.3390/healthcare9070902},
keywords = {endometrial cancer; tumor markers; ER; PR; p53; L1CAM},
language = {eng},
issn = {2227-9032},
journal = {Healthcare},
title = {Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer},
url = {https://www.mdpi.com/2227-9032/9/7/902},
volume = {9},
year = {2021}
}
TY - JOUR
ID - 1784539
AU - Vinklerová, Petra - Bednaříková, Markéta - Minář, Luboš - Felsinger, Michal - Hausnerová, Jitka - Ovesná, Petra - Weinberger, Vít
PY - 2021
TI - Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer
JF - Healthcare
VL - 9
IS - 7
SP - 1-9
EP - 1-9
PB - MDPI
SN - 22279032
KW - endometrial cancer
KW - tumor markers
KW - ER
KW - PR
KW - p53
KW - L1CAM
UR - https://www.mdpi.com/2227-9032/9/7/902
N2 - Endometrial cancer is the most common gynecologic malignancy in Europe and usually diagnosed in its initial stage owing to early symptoms of abnormal bleeding. There is no population screening for this disease, although it can sometimes be accidentally diagnosed in asymptomatic patients. Our study aims to determine differences in clinical and tumor characteristics between an asymptomatic and symptomatic group of patients. This unicentric prospective observational study took place in University Hospital Brno between January 2016 and December 2019. A total of 264 patients met inclusion criteria (26% asymptomatic, 74% with reported symptoms). We did not find a statistically significant difference in clinical characteristics (menopausal status, parity, age, BMI, and serum level of CA 125) between groups. According to ultrasound examination, bleeding tumors were larger (19.5 vs. 12.7 mm, p <= 0.001). Definitive histology results indicated more frequent lymphovascular space invasion (p < 0.001), along with deep myometrial (p = 0.001) and cervical (p = 0.002) invasion. There was no difference in advanced stages of the tumor. We did not substantiate statistically significant difference in immunohistochemical profile (estrogen and progesterone receptors, L1 cell adhesion molecule, tumor protein p53), which is relevant for tumor recurrence risk and survival capacity. Our conclusions affirmed that bleeding occurs more often among patients with local tumor invasion into the myometrium and cervical stroma. Final International Federation of Gynecology and Obstetrics (FIGO) stage, histology, and immunohistochemical characteristics do not significantly affect symptom appearance.
ER -
VINKLEROVÁ, Petra, Markéta BEDNAŘÍKOVÁ, Luboš MINÁŘ, Michal FELSINGER, Jitka HAUSNEROVÁ, Petra OVESNÁ a Vít WEINBERGER. Tumor Characteristic Variations between Symptomatic and Asymptomatic Endometrial Cancer. \textit{Healthcare}. Basel: MDPI, 2021, roč.~9, č.~7, s.~1-9. ISSN~2227-9032. Dostupné z: https://dx.doi.org/10.3390/healthcare9070902.
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