Targeted and suspect screening of plasticizers in house dust to
assess cumulative human exposure risk

J 2021

Targeted and suspect screening of plasticizers in house dust to assess cumulative human exposure risk

DEMIRTEPE, Hale; Lisa Emily MELYMUK; Garry Paul CODLING; L'ubica MURÍNOVÁ; Denisa RICHTEROVA et al.

Základní údaje

Originální název

Targeted and suspect screening of plasticizers in house dust to assess cumulative human exposure risk

Autoři

DEMIRTEPE, Hale; Lisa Emily MELYMUK ; Garry Paul CODLING; L'ubica MURÍNOVÁ; Denisa RICHTEROVA; Vladimira RASPLOVA; Tomáš TRNOVEC a Jana KLÁNOVÁ

Vydání

Science of the Total Environment, Amsterdam, Elsevier Science, 2021, 0048-9697

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.754

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00119118

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Alternative plasticizer; Cumulative risk assessment; Indoor dust; Phthalate ester; Suspect screening

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 6. 2025 09:48, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Indoor dust is an important exposure route to anthropogenic chemicals used in consumer products. Plasticizers are common product additives and can easily leach out of the product and partition to dust. Investigations of plasticizers typically focus on a subset of phthalate esters (PEs), but there are many more PEs in use, and alternative plasticizers (APs) are seeing greater use after recognition of adverse health effects of PEs. In this study we use full scan high resolution mass spectrometry for targeted and suspect screening of PEs and APs in house dust and to assess the potential risk of human exposure. House dust samples from Eastern Slovakia were investigated and concentrations of Sigma 12PEs and Sigma(5)APs ranged 12-2765 mu g/g and 45-13,260 mu g/g, respectively. APs were at similar levels to PEs, indicating common usage of these compounds in products in homes. Evaluation of individual compound toxicity combined with human intake via dust ingestion suggested PEs are of lower priority compared to semivolatile organic compounds such as polychlorinated biphenyls due to their lower toxicity. However, cumulative risk assessment (CRA) is a more appropriate evaluation of risk, considering the presences of many PEs in dust and their similar toxic mode of action. CRA based on median toxicity reference values (TRVs) suggested acceptable risks for dust ingestion, however, the wide range of literature-derived TRVs is a large uncertainty, especially for the APs. Use of newer TRVs suggest risk from dust ingestion alone, i.e. not even considering diet, inhalation, and dermal contact. Additionally, screening of full-scan instrumental spectra identified a further 40 suspect PE compounds, suggesting the CRA based on the 12 target PEs underestimates the risk.

Návaznosti

GA19-20479S, projekt VaV

Název: Prach jako významný zdroj expozice člověka endokrinním disruptorům ve vnitřním protředí

Investor: Grantová agentura ČR, Prach v prostředí jako důležitá expoziční cesta člověka působení endokrinních disruptorů

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

DEMIRTEPE, Hale; Lisa Emily MELYMUK; Garry Paul CODLING; L'ubica MURÍNOVÁ; Denisa RICHTEROVA; Vladimira RASPLOVA; Tomáš TRNOVEC a Jana KLÁNOVÁ. Targeted and suspect screening of plasticizers in house dust to assess cumulative human exposure risk. Science of the Total Environment. Amsterdam: Elsevier Science, 2021, roč. 781, August 2021, s. 1-9. ISSN 0048-9697. Dostupné z: https://doi.org/10.1016/j.scitotenv.2021.146667.

@article{1785038,
   author = {Demirtepe, Hale and Melymuk, Lisa Emily and Codling, Garry Paul and Murínová, L'ubica and Richterova, Denisa and Rasplova, Vladimira and Trnovec, Tomáš and Klánová, Jana},
   article_location = {Amsterdam},
   article_number = {August 2021},
   doi = {https://doi.org/10.1016/j.scitotenv.2021.146667},
   keywords = {Alternative plasticizer; Cumulative risk assessment; Indoor dust; Phthalate ester; Suspect screening},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   title = {Targeted and suspect screening of plasticizers in house dust to assess cumulative human exposure risk},
   url = {https://www.sciencedirect.com/science/article/pii/S0048969721017356?via%3Dihub},
   volume = {781},
   year = {2021}
}

TY  - JOUR
ID  - 1785038
AU  - Demirtepe, Hale - Melymuk, Lisa Emily - Codling, Garry Paul - Murínová, L'ubica - Richterova, Denisa - Rasplova, Vladimira - Trnovec, Tomáš - Klánová, Jana
PY  - 2021
TI  - Targeted and suspect screening of plasticizers in house dust to assess cumulative human exposure risk
JF  - Science of the Total Environment
VL  - 781
IS  - August 2021
SP  - 1-9
EP  - 1-9
PB  - Elsevier Science
SN  - 00489697
KW  - Alternative plasticizer
KW  - Cumulative risk assessment
KW  - Indoor dust
KW  - Phthalate ester
KW  - Suspect screening
UR  - https://www.sciencedirect.com/science/article/pii/S0048969721017356?via%3Dihub
N2  - Indoor dust is an important exposure route to anthropogenic chemicals used in consumer products. Plasticizers are common product additives and can easily leach out of the product and partition to dust. Investigations of plasticizers typically focus on a subset of phthalate esters (PEs), but there are many more PEs in use, and alternative plasticizers (APs) are seeing greater use after recognition of adverse health effects of PEs. In this study we use full scan high resolution mass spectrometry for targeted and suspect screening of PEs and APs in house dust and to assess the potential risk of human exposure. House dust samples from Eastern Slovakia were investigated and concentrations of Sigma 12PEs and Sigma(5)APs ranged 12-2765 mu g/g and 45-13,260 mu g/g, respectively. APs were at similar levels to PEs, indicating common usage of these compounds in products in homes. Evaluation of individual compound toxicity combined with human intake via dust ingestion suggested PEs are of lower priority compared to semivolatile organic compounds such as polychlorinated biphenyls due to their lower toxicity. However, cumulative risk assessment (CRA) is a more appropriate evaluation of risk, considering the presences of many PEs in dust and their similar toxic mode of action. CRA based on median toxicity reference values (TRVs) suggested acceptable risks for dust ingestion, however, the wide range of literature-derived TRVs is a large uncertainty, especially for the APs. Use of newer TRVs suggest risk from dust ingestion alone, i.e. not even considering diet, inhalation, and dermal contact. Additionally, screening of full-scan instrumental spectra identified a further 40 suspect PE compounds, suggesting the CRA based on the 12 target PEs underestimates the risk.
ER  -

DEMIRTEPE, Hale; Lisa Emily MELYMUK; Garry Paul CODLING; L'ubica MURÍNOVÁ; Denisa RICHTEROVA; Vladimira RASPLOVA; Tomáš TRNOVEC a Jana KLÁNOVÁ. Targeted and suspect screening of plasticizers in house dust to assess cumulative human exposure risk. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2021, roč.~781, August 2021, s.~1-9. ISSN~0048-9697. Dostupné z: https://doi.org/10.1016/j.scitotenv.2021.146667.

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