A model of perinatal stress and childhood wheezing: ELSPAC-CZ
cohort

J 2021

A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort

ŠTĚPANÍKOVÁ, Irena; Vojtěch THON; Ondřej MIKEŠ a Jana KLÁNOVÁ

Základní údaje

Originální název

A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort

Autoři

ŠTĚPANÍKOVÁ, Irena; Vojtěch THON; Ondřej MIKEŠ a Jana KLÁNOVÁ

Vydání

Pediatric Pulmonology, Hoboken, Wiley, 2021, 8755-6863

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.090

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00122092

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

child wheezing; early life stress; maternal depression; resiratory infections

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 6. 2025 14:42, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Background Prenatal origins of wheezing are not fully understood. This study develops a model of mechanisms linking perinatal stress exposure to wheeze phenotypes in children. Methods Data were obtained from 1880 mother-child dyads participating in ELSPAC-CZ birth cohort. Wheeze phenotypes assessed between birth and age 7 years included "never wheeze," "early-onset transient (EOT) wheeze," "early-onset persistent (EOP) wheeze," and "late-onset (LO) wheeze." Prenatal and postnatal stress exposures were assessed in mid-pregnancy and 6 months after delivery, respectively, using an inventory of 42 life events. Results In adjusted models, children in the highest tercile (high) versus lowest tercile (low) for prenatal life events had a 38% higher risk of EOT wheeze (relative risk ratio [RRR] = 1.38; 95% confidence interval [CI] = 1.01-1.88; p = .041) and 50% higher risk of LO wheeze (RRR = 1.50; 95% CI = 1.00-2.25; p = .047). High versus low exposure to postnatal life events predicted a 60% increase in relative risk of EOT wheeze (RRR = 1.60; 95% CI = 1.17-2.19; p = .003) and medium versus low exposure was related to an 85% increase in relative risk of EOP wheeze (RRR = 1.85; 95% CI = 1.16-2.95; p = .010). Lower respiratory tract infections and postpartum depression partially mediated between postnatal life events and any wheeze (indirect effects 1.06, 95% CI = 1.02-1.09, p = .003 and odds ratio [OR] = 1.08, 95% CI = 1.02-1.15, p = .012, respectively), while postnatal events mediate for prenatal events (indirect effect OR = 1.11; 95% CI = 1.03-1.18; p = .005). Conclusions Exposures to prenatal and postnatal life events are risk factors for the development of wheezing. Prenatal stress contributes to wheeze directly and also through postnatal life events, respiratory infections, and maternal depression.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF16_013/0001761, projekt VaV

Název: RECETOX RI

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

ŠTĚPANÍKOVÁ, Irena; Vojtěch THON; Ondřej MIKEŠ a Jana KLÁNOVÁ. A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort. Pediatric Pulmonology. Hoboken: Wiley, 2021, roč. 56, č. 6, s. 1471-1483. ISSN 8755-6863. Dostupné z: https://doi.org/10.1002/ppul.25346.

@article{1786144,
   author = {Štěpaníková, Irena and Thon, Vojtěch and Mikeš, Ondřej and Klánová, Jana},
   article_location = {Hoboken},
   article_number = {6},
   doi = {https://doi.org/10.1002/ppul.25346},
   keywords = {child wheezing; early life stress; maternal depression; resiratory infections},
   language = {eng},
   issn = {8755-6863},
   journal = {Pediatric Pulmonology},
   title = {A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/ppul.25346},
   volume = {56},
   year = {2021}
}

TY  - JOUR
ID  - 1786144
AU  - Štěpaníková, Irena - Thon, Vojtěch - Mikeš, Ondřej - Klánová, Jana
PY  - 2021
TI  - A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort
JF  - Pediatric Pulmonology
VL  - 56
IS  - 6
SP  - 1471-1483
EP  - 1471-1483
PB  - Wiley
SN  - 87556863
KW  - child wheezing
KW  - early life stress
KW  - maternal depression
KW  - resiratory infections
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ppul.25346
N2  - Background Prenatal origins of wheezing are not fully understood. This study develops a model of mechanisms linking perinatal stress exposure to wheeze phenotypes in children. Methods Data were obtained from 1880 mother-child dyads participating in ELSPAC-CZ birth cohort. Wheeze phenotypes assessed between birth and age 7 years included "never wheeze," "early-onset transient (EOT) wheeze," "early-onset persistent (EOP) wheeze," and "late-onset (LO) wheeze." Prenatal and postnatal stress exposures were assessed in mid-pregnancy and 6 months after delivery, respectively, using an inventory of 42 life events. Results In adjusted models, children in the highest tercile (high) versus lowest tercile (low) for prenatal life events had a 38% higher risk of EOT wheeze (relative risk ratio [RRR] = 1.38; 95% confidence interval [CI] = 1.01-1.88; p = .041) and 50% higher risk of LO wheeze (RRR = 1.50; 95% CI = 1.00-2.25; p = .047). High versus low exposure to postnatal life events predicted a 60% increase in relative risk of EOT wheeze (RRR = 1.60; 95% CI = 1.17-2.19; p = .003) and medium versus low exposure was related to an 85% increase in relative risk of EOP wheeze (RRR = 1.85; 95% CI = 1.16-2.95; p = .010). Lower respiratory tract infections and postpartum depression partially mediated between postnatal life events and any wheeze (indirect effects 1.06, 95% CI = 1.02-1.09, p = .003 and odds ratio [OR] = 1.08, 95% CI = 1.02-1.15, p = .012, respectively), while postnatal events mediate for prenatal events (indirect effect OR = 1.11; 95% CI = 1.03-1.18; p = .005). Conclusions Exposures to prenatal and postnatal life events are risk factors for the development of wheezing. Prenatal stress contributes to wheeze directly and also through postnatal life events, respiratory infections, and maternal depression.
ER  -

ŠTĚPANÍKOVÁ, Irena; Vojtěch THON; Ondřej MIKEŠ a Jana KLÁNOVÁ. A model of perinatal stress and childhood wheezing: ELSPAC-CZ cohort. \textit{Pediatric Pulmonology}. Hoboken: Wiley, 2021, roč.~56, č.~6, s.~1471-1483. ISSN~8755-6863. Dostupné z: https://doi.org/10.1002/ppul.25346.

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