Pathophysiological Implication of Vitamin D in Diabetic Kidney
Disease

J 2021

Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease

GALUŠKA, David, Lukáš PÁCAL a Kateřina KAŇKOVÁ

Základní údaje

Originální název

Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease

Autoři

GALUŠKA, David (203 Česká republika, domácí), Lukáš PÁCAL (203 Česká republika, domácí) a Kateřina KAŇKOVÁ (203 Česká republika, domácí)

Vydání

KIDNEY & BLOOD PRESSURE RESEARCH, BASEL, KARGER, 2021, 1420-4096

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.096

Kód RIV

RIV/00216224:14110/21:00120127

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1159/000514286

UT WoS

000632543100001

Klíčová slova anglicky

Diabetes mellitus; Vitamin D; Diabetic kidney disease; Sodium-glucose linked co-transporter 2 inhibitors

Štítky

14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 2. 2022 13:57, Mgr. Tereza Miškechová

Anotace

V originále

Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. Summary: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states.

Návaznosti

MUNI/A/1698/2020, interní kód MU

Název: Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí (Akronym: ComplexPF)

Investor: Masarykova univerzita, Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí

NV18-01-00046, projekt VaV

Název: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministerstvo zdravotnictví ČR, Genetické skóre v predikci rizika diabetu a jeho komplikací

Citovat

GALUŠKA, David, Lukáš PÁCAL a Kateřina KAŇKOVÁ. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease. KIDNEY & BLOOD PRESSURE RESEARCH. BASEL: KARGER, 2021, roč. 46, č. 2, s. 152-161. ISSN 1420-4096. Dostupné z: https://dx.doi.org/10.1159/000514286.

@article{1787361,
   author = {Galuška, David and Pácal, Lukáš and Kaňková, Kateřina},
   article_location = {BASEL},
   article_number = {2},
   doi = {http://dx.doi.org/10.1159/000514286},
   keywords = {Diabetes mellitus; Vitamin D; Diabetic kidney disease; Sodium-glucose linked co-transporter 2 inhibitors},
   language = {eng},
   issn = {1420-4096},
   journal = {KIDNEY & BLOOD PRESSURE RESEARCH},
   title = {Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease},
   url = {https://www.karger.com/Article/FullText/514286},
   volume = {46},
   year = {2021}
}

TY  - JOUR
ID  - 1787361
AU  - Galuška, David - Pácal, Lukáš - Kaňková, Kateřina
PY  - 2021
TI  - Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease
JF  - KIDNEY & BLOOD PRESSURE RESEARCH
VL  - 46
IS  - 2
SP  - 152-161
EP  - 152-161
PB  - KARGER
SN  - 14204096
KW  - Diabetes mellitus
KW  - Vitamin D
KW  - Diabetic kidney disease
KW  - Sodium-glucose linked co-transporter 2 inhibitors
UR  - https://www.karger.com/Article/FullText/514286
N2  - Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. Summary: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states.
ER  -

GALUŠKA, David, Lukáš PÁCAL a Kateřina KAŇKOVÁ. Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease. \textit{KIDNEY \&{} BLOOD PRESSURE RESEARCH}. BASEL: KARGER, 2021, roč.~46, č.~2, s.~152-161. ISSN~1420-4096. Dostupné z: https://dx.doi.org/10.1159/000514286.

Podrobný výpis o publikaci