Donor specific anti-HLA antibodies and cardiac allograft
vasculopathy: A prospective study using highly automated 3-D
optical coherence tomography analysis

J 2021

Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

PAZDERNIK, Michal; Helena BEDANOVA; Zhi CHEN; Josef KAUTZNER; Vojtech MELENOVSKY et al.

Základní údaje

Originální název

Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis

Autoři

Vydání

Transplant Immunology, Amsterdam, ELSEVIER, 2021, 0966-3274

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30213 Transplantation

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.032

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/21:00122148

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Cardiac allograft vasculopathy; Donor specific antibodies; Heart transplant; Intimal thickness

Štítky

14110115, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 8. 2021 08:58, Mgr. Tereza Miškechová

Anotace

V originále

Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.

Citovat

PAZDERNIK, Michal; Helena BEDANOVA; Zhi CHEN; Josef KAUTZNER; Vojtech MELENOVSKY; Ivan MALEK; Antonij SLAVCEV; Michaela BARTONOVA; Vladimir KARMAZIN; Tomas ECKHARDT; Ales TOMASEK; Eva OZÁBALOVÁ; Tomas KOVARNIK; Peter WOHLFAHRT a Milan SONKA. Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis. Transplant Immunology. Amsterdam: ELSEVIER, 2021, roč. 65, April 2021, s. 1-8. ISSN 0966-3274. Dostupné z: https://doi.org/10.1016/j.trim.2020.101340.

@article{1787477,
   author = {Pazdernik, Michal and Bedanova, Helena and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Malek, Ivan and Slavcev, Antonij and Bartonova, Michaela and Karmazin, Vladimir and Eckhardt, Tomas and Tomasek, Ales and Ozábalová, Eva and Kovarnik, Tomas and Wohlfahrt, Peter and Sonka, Milan},
   article_location = {Amsterdam},
   article_number = {April 2021},
   doi = {https://doi.org/10.1016/j.trim.2020.101340},
   keywords = {Cardiac allograft vasculopathy; Donor specific antibodies; Heart transplant; Intimal thickness},
   language = {eng},
   issn = {0966-3274},
   journal = {Transplant Immunology},
   title = {Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis},
   url = {https://www.sciencedirect.com/science/article/pii/S0966327420301489?via%3Dihub},
   volume = {65},
   year = {2021}
}

TY  - JOUR
ID  - 1787477
AU  - Pazdernik, Michal - Bedanova, Helena - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Malek, Ivan - Slavcev, Antonij - Bartonova, Michaela - Karmazin, Vladimir - Eckhardt, Tomas - Tomasek, Ales - Ozábalová, Eva - Kovarnik, Tomas - Wohlfahrt, Peter - Sonka, Milan
PY  - 2021
TI  - Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis
JF  - Transplant Immunology
VL  - 65
IS  - April 2021
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER
SN  - 09663274
KW  - Cardiac allograft vasculopathy
KW  - Donor specific antibodies
KW  - Heart transplant
KW  - Intimal thickness
UR  - https://www.sciencedirect.com/science/article/pii/S0966327420301489?via%3Dihub
N2  - Introduction: Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). Methods: This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. Results: During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Conclusion: Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.
ER  -

PAZDERNIK, Michal; Helena BEDANOVA; Zhi CHEN; Josef KAUTZNER; Vojtech MELENOVSKY; Ivan MALEK; Antonij SLAVCEV; Michaela BARTONOVA; Vladimir KARMAZIN; Tomas ECKHARDT; Ales TOMASEK; Eva OZÁBALOVÁ; Tomas KOVARNIK; Peter WOHLFAHRT a Milan SONKA. Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis. \textit{Transplant Immunology}. Amsterdam: ELSEVIER, 2021, roč.~65, April 2021, s.~1-8. ISSN~0966-3274. Dostupné z: https://doi.org/10.1016/j.trim.2020.101340.

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