Aspergillus fumigatus tryptophan metabolic route differently
affects host immunity

J 2021

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

ZELANTE, Teresa; Tsokyi CHOERA; Anne BEAUVAIS; Francesca FALLARINO; Giuseppe PAOLICELLI et al.

Základní údaje

Originální název

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

Autoři

Vydání

Cell Reports, CAMBRIDGE, Cell Press, 2021, 2211-1247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.995

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00119159

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

aspergillosis; indoles; Aspergillus fumigatus; IDO; tryptophan; AhR; IL-33; NAD; inflammation

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 6. 2025 20:49, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Indoleamine 2,3-dioxygenases (Ms) degrade L-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide. Unsurprisingly, various invertebrates, vertebrates, and even fungi produce IDO. In mammals, IDO1 also serves as a homeostatic regulator, modulating immune response to infection via local tryptophan deprivation, active catabolite production, and non-enzymatic cell signaling, Whether fungal !dos have pleiotropic functions that impact on host-fungal physiology is unclear. Here, we show that Aspergillus fumigatus possesses three ido genes that are expressed under conditions of hypoxia or tryptophan abundance. Loss of these genes results in increased fungal pathogenicity and inflammation in a mouse model of aspergillosis, driven by an alternative tryptophan degradation pathway to indole derivatives and the host aryl hydrocarbon receptor. Fungal tryptophan metabolic pathways thus cooperate with the host xenobiotic response to shape host-microbe interactions in local tissue microenvironments.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF16_013/0001761, projekt VaV

Název: RECETOX RI

GJ17-24592Y, projekt VaV

Název: Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

Investor: Grantová agentura ČR, Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

90051, velká výzkumná infrastruktura

Název: RECETOX II

Citovat

ZELANTE, Teresa; Tsokyi CHOERA; Anne BEAUVAIS; Francesca FALLARINO; Giuseppe PAOLICELLI; Giuseppe PIERACCINI; Marco PIERONI; Claudia GALOSI; Claudia BEATO; Antonella DE LUCA; Francesca BOSCARO; Riccardo ROMOLI; Xin LIU; Adilia WARRIS; Paul E. VERWEIJ; Eloise BALLARD; Monica BORGHI; Marilena PARIANO; Gabriele COSTANTINO; Mario CALVITTI; Carmine VACCA; Vasilis OIKONOMOU; Marco GARGARO; Alicia Yoke Wei WONG; Louis BOON; Marcel DEN HARTOG; Zdeněk SPÁČIL; Paolo PUCCETTI; Jean-Paul LATGE; Nancy P. KELLER a Luigina ROMANI. Aspergillus fumigatus tryptophan metabolic route differently affects host immunity. Cell Reports. CAMBRIDGE: Cell Press, 2021, roč. 34, č. 4, s. 1-20. ISSN 2211-1247. Dostupné z: https://doi.org/10.1016/j.celrep.2020.108673.

@article{1788181,
   author = {Zelante, Teresa and Choera, Tsokyi and Beauvais, Anne and Fallarino, Francesca and Paolicelli, Giuseppe and Pieraccini, Giuseppe and Pieroni, Marco and Galosi, Claudia and Beato, Claudia and De Luca, Antonella and Boscaro, Francesca and Romoli, Riccardo and Liu, Xin and Warris, Adilia and Verweij, Paul E. and Ballard, Eloise and Borghi, Monica and Pariano, Marilena and Costantino, Gabriele and Calvitti, Mario and Vacca, Carmine and Oikonomou, Vasilis and Gargaro, Marco and Wong, Alicia Yoke Wei and Boon, Louis and den Hartog, Marcel and Spáčil, Zdeněk and Puccetti, Paolo and Latge, JeanandPaul and Keller, Nancy P. and Romani, Luigina},
   article_location = {CAMBRIDGE},
   article_number = {4},
   doi = {https://doi.org/10.1016/j.celrep.2020.108673},
   keywords = {aspergillosis; indoles; Aspergillus fumigatus; IDO; tryptophan; AhR; IL-33; NAD; inflammation},
   language = {eng},
   issn = {2211-1247},
   journal = {Cell Reports},
   title = {Aspergillus fumigatus tryptophan metabolic route differently affects host immunity},
   url = {https://www.sciencedirect.com/science/article/pii/S2211124720316624?via%3Dihub},
   volume = {34},
   year = {2021}
}

TY  - JOUR
ID  - 1788181
AU  - Zelante, Teresa - Choera, Tsokyi - Beauvais, Anne - Fallarino, Francesca - Paolicelli, Giuseppe - Pieraccini, Giuseppe - Pieroni, Marco - Galosi, Claudia - Beato, Claudia - De Luca, Antonella - Boscaro, Francesca - Romoli, Riccardo - Liu, Xin - Warris, Adilia - Verweij, Paul E. - Ballard, Eloise - Borghi, Monica - Pariano, Marilena - Costantino, Gabriele - Calvitti, Mario - Vacca, Carmine - Oikonomou, Vasilis - Gargaro, Marco - Wong, Alicia Yoke Wei - Boon, Louis - den Hartog, Marcel - Spáčil, Zdeněk - Puccetti, Paolo - Latge, Jean-Paul - Keller, Nancy P. - Romani, Luigina
PY  - 2021
TI  - Aspergillus fumigatus tryptophan metabolic route differently affects host immunity
JF  - Cell Reports
VL  - 34
IS  - 4
SP  - 1-20
EP  - 1-20
PB  - Cell Press
SN  - 22111247
KW  - aspergillosis
KW  - indoles
KW  - Aspergillus fumigatus
KW  - IDO
KW  - tryptophan
KW  - AhR
KW  - IL-33
KW  - NAD
KW  - inflammation
UR  - https://www.sciencedirect.com/science/article/pii/S2211124720316624?via%3Dihub
N2  - Indoleamine 2,3-dioxygenases (Ms) degrade L-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide. Unsurprisingly, various invertebrates, vertebrates, and even fungi produce IDO. In mammals, IDO1 also serves as a homeostatic regulator, modulating immune response to infection via local tryptophan deprivation, active catabolite production, and non-enzymatic cell signaling, Whether fungal !dos have pleiotropic functions that impact on host-fungal physiology is unclear. Here, we show that Aspergillus fumigatus possesses three ido genes that are expressed under conditions of hypoxia or tryptophan abundance. Loss of these genes results in increased fungal pathogenicity and inflammation in a mouse model of aspergillosis, driven by an alternative tryptophan degradation pathway to indole derivatives and the host aryl hydrocarbon receptor. Fungal tryptophan metabolic pathways thus cooperate with the host xenobiotic response to shape host-microbe interactions in local tissue microenvironments.
ER  -

ZELANTE, Teresa; Tsokyi CHOERA; Anne BEAUVAIS; Francesca FALLARINO; Giuseppe PAOLICELLI; Giuseppe PIERACCINI; Marco PIERONI; Claudia GALOSI; Claudia BEATO; Antonella DE LUCA; Francesca BOSCARO; Riccardo ROMOLI; Xin LIU; Adilia WARRIS; Paul E. VERWEIJ; Eloise BALLARD; Monica BORGHI; Marilena PARIANO; Gabriele COSTANTINO; Mario CALVITTI; Carmine VACCA; Vasilis OIKONOMOU; Marco GARGARO; Alicia Yoke Wei WONG; Louis BOON; Marcel DEN HARTOG; Zdeněk SPÁČIL; Paolo PUCCETTI; Jean-Paul LATGE; Nancy P. KELLER a Luigina ROMANI. Aspergillus fumigatus tryptophan metabolic route differently affects host immunity. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2021, roč.~34, č.~4, s.~1-20. ISSN~2211-1247. Dostupné z: https://doi.org/10.1016/j.celrep.2020.108673.

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