Aspergillus fumigatus tryptophan metabolic route differently
affects host immunity

J 2021

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

ZELANTE, Teresa, Tsokyi CHOERA, Anne BEAUVAIS, Francesca FALLARINO, Giuseppe PAOLICELLI et. al.

Basic information

Original name

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

Authors

ZELANTE, Teresa (380 Italy), Tsokyi CHOERA (840 United States of America), Anne BEAUVAIS (250 France), Francesca FALLARINO (380 Italy), Giuseppe PAOLICELLI (380 Italy), Giuseppe PIERACCINI (380 Italy), Marco PIERONI (380 Italy), Claudia GALOSI, Claudia BEATO (380 Italy), Antonella DE LUCA (380 Italy), Francesca BOSCARO (380 Italy), Riccardo ROMOLI (380 Italy), Xin LIU (840 United States of America), Adilia WARRIS (826 United Kingdom of Great Britain and Northern Ireland), Paul E. VERWEIJ (528 Netherlands), Eloise BALLARD (826 United Kingdom of Great Britain and Northern Ireland), Monica BORGHI (380 Italy), Marilena PARIANO (380 Italy), Gabriele COSTANTINO (380 Italy), Mario CALVITTI (380 Italy), Carmine VACCA (380 Italy), Vasilis OIKONOMOU (380 Italy), Marco GARGARO (380 Italy), Alicia Yoke Wei WONG (702 Singapore), Louis BOON (528 Netherlands), Marcel DEN HARTOG (528 Netherlands), Zdeněk SPÁČIL (203 Czech Republic, guarantor, belonging to the institution), Paolo PUCCETTI (380 Italy), Jean-Paul LATGE (250 France), Nancy P. KELLER (840 United States of America) and Luigina ROMANI (528 Netherlands)

Edition

Cell Reports, CAMBRIDGE, Cell Press, 2021, 2211-1247

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 9.995

RIV identification code

RIV/00216224:14310/21:00119159

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.celrep.2020.108673

UT WoS

000613631500015

Keywords in English

aspergillosis; indoles; Aspergillus fumigatus; IDO; tryptophan; AhR; IL-33; NAD; inflammation

Abstract

V originále

Indoleamine 2,3-dioxygenases (Ms) degrade L-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide. Unsurprisingly, various invertebrates, vertebrates, and even fungi produce IDO. In mammals, IDO1 also serves as a homeostatic regulator, modulating immune response to infection via local tryptophan deprivation, active catabolite production, and non-enzymatic cell signaling, Whether fungal !dos have pleiotropic functions that impact on host-fungal physiology is unclear. Here, we show that Aspergillus fumigatus possesses three ido genes that are expressed under conditions of hypoxia or tryptophan abundance. Loss of these genes results in increased fungal pathogenicity and inflammation in a mouse model of aspergillosis, driven by an alternative tryptophan degradation pathway to indole derivatives and the host aryl hydrocarbon receptor. Fungal tryptophan metabolic pathways thus cooperate with the host xenobiotic response to shape host-microbe interactions in local tissue microenvironments.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

EF16_013/0001761, research and development project

Name: RECETOX RI

GJ17-24592Y, research and development project

Name: Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

Investor: Czech Science Foundation

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

ZELANTE, Teresa, Tsokyi CHOERA, Anne BEAUVAIS, Francesca FALLARINO, Giuseppe PAOLICELLI, Giuseppe PIERACCINI, Marco PIERONI, Claudia GALOSI, Claudia BEATO, Antonella DE LUCA, Francesca BOSCARO, Riccardo ROMOLI, Xin LIU, Adilia WARRIS, Paul E. VERWEIJ, Eloise BALLARD, Monica BORGHI, Marilena PARIANO, Gabriele COSTANTINO, Mario CALVITTI, Carmine VACCA, Vasilis OIKONOMOU, Marco GARGARO, Alicia Yoke Wei WONG, Louis BOON, Marcel DEN HARTOG, Zdeněk SPÁČIL, Paolo PUCCETTI, Jean-Paul LATGE, Nancy P. KELLER and Luigina ROMANI. Aspergillus fumigatus tryptophan metabolic route differently affects host immunity. Cell Reports. CAMBRIDGE: Cell Press, 2021, vol. 34, No 4, p. 1-20. ISSN 2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2020.108673.

@article{1788181,
   author = {Zelante, Teresa and Choera, Tsokyi and Beauvais, Anne and Fallarino, Francesca and Paolicelli, Giuseppe and Pieraccini, Giuseppe and Pieroni, Marco and Galosi, Claudia and Beato, Claudia and De Luca, Antonella and Boscaro, Francesca and Romoli, Riccardo and Liu, Xin and Warris, Adilia and Verweij, Paul E. and Ballard, Eloise and Borghi, Monica and Pariano, Marilena and Costantino, Gabriele and Calvitti, Mario and Vacca, Carmine and Oikonomou, Vasilis and Gargaro, Marco and Wong, Alicia Yoke Wei and Boon, Louis and den Hartog, Marcel and Spáčil, Zdeněk and Puccetti, Paolo and Latge, JeanandPaul and Keller, Nancy P. and Romani, Luigina},
   article_location = {CAMBRIDGE},
   article_number = {4},
   doi = {http://dx.doi.org/10.1016/j.celrep.2020.108673},
   keywords = {aspergillosis; indoles; Aspergillus fumigatus; IDO; tryptophan; AhR; IL-33; NAD; inflammation},
   language = {eng},
   issn = {2211-1247},
   journal = {Cell Reports},
   title = {Aspergillus fumigatus tryptophan metabolic route differently affects host immunity},
   url = {https://www.sciencedirect.com/science/article/pii/S2211124720316624?via%3Dihub},
   volume = {34},
   year = {2021}
}

TY  - JOUR
ID  - 1788181
AU  - Zelante, Teresa - Choera, Tsokyi - Beauvais, Anne - Fallarino, Francesca - Paolicelli, Giuseppe - Pieraccini, Giuseppe - Pieroni, Marco - Galosi, Claudia - Beato, Claudia - De Luca, Antonella - Boscaro, Francesca - Romoli, Riccardo - Liu, Xin - Warris, Adilia - Verweij, Paul E. - Ballard, Eloise - Borghi, Monica - Pariano, Marilena - Costantino, Gabriele - Calvitti, Mario - Vacca, Carmine - Oikonomou, Vasilis - Gargaro, Marco - Wong, Alicia Yoke Wei - Boon, Louis - den Hartog, Marcel - Spáčil, Zdeněk - Puccetti, Paolo - Latge, Jean-Paul - Keller, Nancy P. - Romani, Luigina
PY  - 2021
TI  - Aspergillus fumigatus tryptophan metabolic route differently affects host immunity
JF  - Cell Reports
VL  - 34
IS  - 4
SP  - 1-20
EP  - 1-20
PB  - Cell Press
SN  - 22111247
KW  - aspergillosis
KW  - indoles
KW  - Aspergillus fumigatus
KW  - IDO
KW  - tryptophan
KW  - AhR
KW  - IL-33
KW  - NAD
KW  - inflammation
UR  - https://www.sciencedirect.com/science/article/pii/S2211124720316624?via%3Dihub
N2  - Indoleamine 2,3-dioxygenases (Ms) degrade L-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide. Unsurprisingly, various invertebrates, vertebrates, and even fungi produce IDO. In mammals, IDO1 also serves as a homeostatic regulator, modulating immune response to infection via local tryptophan deprivation, active catabolite production, and non-enzymatic cell signaling, Whether fungal !dos have pleiotropic functions that impact on host-fungal physiology is unclear. Here, we show that Aspergillus fumigatus possesses three ido genes that are expressed under conditions of hypoxia or tryptophan abundance. Loss of these genes results in increased fungal pathogenicity and inflammation in a mouse model of aspergillosis, driven by an alternative tryptophan degradation pathway to indole derivatives and the host aryl hydrocarbon receptor. Fungal tryptophan metabolic pathways thus cooperate with the host xenobiotic response to shape host-microbe interactions in local tissue microenvironments.
ER  -

ZELANTE, Teresa, Tsokyi CHOERA, Anne BEAUVAIS, Francesca FALLARINO, Giuseppe PAOLICELLI, Giuseppe PIERACCINI, Marco PIERONI, Claudia GALOSI, Claudia BEATO, Antonella DE LUCA, Francesca BOSCARO, Riccardo ROMOLI, Xin LIU, Adilia WARRIS, Paul E. VERWEIJ, Eloise BALLARD, Monica BORGHI, Marilena PARIANO, Gabriele COSTANTINO, Mario CALVITTI, Carmine VACCA, Vasilis OIKONOMOU, Marco GARGARO, Alicia Yoke Wei WONG, Louis BOON, Marcel DEN HARTOG, Zdeněk SPÁČIL, Paolo PUCCETTI, Jean-Paul LATGE, Nancy P. KELLER and Luigina ROMANI. Aspergillus fumigatus tryptophan metabolic route differently affects host immunity. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2021, vol.~34, No~4, p.~1-20. ISSN~2211-1247. Available from: https://dx.doi.org/10.1016/j.celrep.2020.108673.

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