Variability in retinoid-like activity of extracellular compound
mixtures produced by wide spectra of phytoplankton species and
contributing metabolites

J 2021

Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites

SMUTNÁ, Marie; Jaroslava VEČERKOVÁ; Jana PRIEBOJOVÁ; Marek PÍPAL; Martin KRAUSS et al.

Základní údaje

Originální název

Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites

Autoři

SMUTNÁ, Marie; Jaroslava VEČERKOVÁ; Jana PRIEBOJOVÁ; Marek PÍPAL; Martin KRAUSS a Klára HILSCHEROVÁ

Vydání

Journal of Hazardous Materials, Amsterdam, Elsevier Science BV. 2021, 0304-3894

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 14.224

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00119169

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Retinoic acid receptor; Cyanobacteria; Exudates; Retinoids; Retinoid-like activity

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 6. 2025 20:46, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Some phytoplankton species were shown to produce teratogenic retinoids. This study assessed the variability in the extracellular production of compounds with retinoid-like activity for 50 independent cultivations of wide spectra of species including 12 cyanobacteria (15 strains) and 4 algae of different orders. Extracellular retinoidlike activity was detected for repeated cultivations of six cyanobacteria. The results were consistent for some species including Microcystis aeruginosa and Aphanizomenon gracile. The detected retinoid-like activities ranged from below the limit of quantification of 16 ng/L to over 6 mu g all-trans retinoic acid (ATRA) equivalent/L. Nontargeted virtual fractionation together with suspect screening approach enabled to identify some retinoidlike compounds in exudates, including ATRA, 9/13-cis retinoic acid, all-trans 5,6-epoxy retinoic acid, 4ketoATRA, 4keto-retinal, 4hydroxy-ATRA, and retinal. Most of them were for the first time repeatedly detected in exudates of all studied algae (at ng/L levels) and cyanobacteria. Their relative potencies ranged from 0.018 (retinal) to 1 compared to ATRA. They accounted for less than 0.1-50% of total detected retinoid-like activity. The high detected activities and concentrations of retinoids in some samples and their direct accessibility from exudates document potential risk of developmental toxicity for organisms in proximity of massive water blooms.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

GA18-15199S, projekt VaV

Název: Bioaktivní látky ze sinic ovlivňující signálování jaderných receptorů a vývoj obratlovců

Investor: Grantová agentura ČR, Bioaktivní látky ze sinic ovlivňující signálování jaderných receptorů a vývoj obratlovců

GX20-04676X, projekt VaV

Název: Holistická charakterizace expozice a potenciálních účinků komplexních směsí chemických látek ve vodním prostředí

Investor: Grantová agentura ČR, Holistická charakterizace expozice a potenciálních účinků komplexních směsí chemických látek ve vodním prostředí

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

SMUTNÁ, Marie; Jaroslava VEČERKOVÁ; Jana PRIEBOJOVÁ; Marek PÍPAL; Martin KRAUSS a Klára HILSCHEROVÁ. Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites. Journal of Hazardous Materials. Amsterdam: Elsevier Science BV., 2021, roč. 414, July 2021, s. 1-10. ISSN 0304-3894. Dostupné z: https://doi.org/10.1016/j.jhazmat.2021.125412.

@article{1789138,
   author = {Smutná, Marie and Večerková, Jaroslava and Priebojová, Jana and Pípal, Marek and Krauss, Martin and Hilscherová, Klára},
   article_location = {Amsterdam},
   article_number = {July 2021},
   doi = {https://doi.org/10.1016/j.jhazmat.2021.125412},
   keywords = {Retinoic acid receptor; Cyanobacteria; Exudates; Retinoids; Retinoid-like activity},
   language = {eng},
   issn = {0304-3894},
   journal = {Journal of Hazardous Materials},
   title = {Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites},
   url = {https://www.sciencedirect.com/science/article/pii/S0304389421003757?via%3Dihub},
   volume = {414},
   year = {2021}
}

TY  - JOUR
ID  - 1789138
AU  - Smutná, Marie - Večerková, Jaroslava - Priebojová, Jana - Pípal, Marek - Krauss, Martin - Hilscherová, Klára
PY  - 2021
TI  - Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites
JF  - Journal of Hazardous Materials
VL  - 414
IS  - July 2021
SP  - 1-10
EP  - 1-10
PB  - Elsevier Science BV.
SN  - 03043894
KW  - Retinoic acid receptor
KW  - Cyanobacteria
KW  - Exudates
KW  - Retinoids
KW  - Retinoid-like activity
UR  - https://www.sciencedirect.com/science/article/pii/S0304389421003757?via%3Dihub
N2  - Some phytoplankton species were shown to produce teratogenic retinoids. This study assessed the variability in the extracellular production of compounds with retinoid-like activity for 50 independent cultivations of wide spectra of species including 12 cyanobacteria (15 strains) and 4 algae of different orders. Extracellular retinoidlike activity was detected for repeated cultivations of six cyanobacteria. The results were consistent for some species including Microcystis aeruginosa and Aphanizomenon gracile. The detected retinoid-like activities ranged from below the limit of quantification of 16 ng/L to over 6 mu g all-trans retinoic acid (ATRA) equivalent/L. Nontargeted virtual fractionation together with suspect screening approach enabled to identify some retinoidlike compounds in exudates, including ATRA, 9/13-cis retinoic acid, all-trans 5,6-epoxy retinoic acid, 4ketoATRA, 4keto-retinal, 4hydroxy-ATRA, and retinal. Most of them were for the first time repeatedly detected in exudates of all studied algae (at ng/L levels) and cyanobacteria. Their relative potencies ranged from 0.018 (retinal) to 1 compared to ATRA. They accounted for less than 0.1-50% of total detected retinoid-like activity. The high detected activities and concentrations of retinoids in some samples and their direct accessibility from exudates document potential risk of developmental toxicity for organisms in proximity of massive water blooms.
ER  -

SMUTNÁ, Marie; Jaroslava VEČERKOVÁ; Jana PRIEBOJOVÁ; Marek PÍPAL; Martin KRAUSS a Klára HILSCHEROVÁ. Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2021, roč.~414, July 2021, s.~1-10. ISSN~0304-3894. Dostupné z: https://doi.org/10.1016/j.jhazmat.2021.125412.

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