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@article{1789138,
author = {Smutná, Marie and Večerková, Jaroslava and Priebojová, Jana and Pípal, Marek and Krauss, Martin and Hilscherová, Klára},
article_location = {Amsterdam},
article_number = {July 2021},
doi = {http://dx.doi.org/10.1016/j.jhazmat.2021.125412},
keywords = {Retinoic acid receptor; Cyanobacteria; Exudates; Retinoids; Retinoid-like activity},
language = {eng},
issn = {0304-3894},
journal = {Journal of Hazardous Materials},
title = {Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites},
url = {https://www.sciencedirect.com/science/article/pii/S0304389421003757?via%3Dihub},
volume = {414},
year = {2021}
}
TY - JOUR
ID - 1789138
AU - Smutná, Marie - Večerková, Jaroslava - Priebojová, Jana - Pípal, Marek - Krauss, Martin - Hilscherová, Klára
PY - 2021
TI - Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites
JF - Journal of Hazardous Materials
VL - 414
IS - July 2021
SP - 1-10
EP - 1-10
PB - Elsevier Science BV.
SN - 03043894
KW - Retinoic acid receptor
KW - Cyanobacteria
KW - Exudates
KW - Retinoids
KW - Retinoid-like activity
UR - https://www.sciencedirect.com/science/article/pii/S0304389421003757?via%3Dihub
N2 - Some phytoplankton species were shown to produce teratogenic retinoids. This study assessed the variability in the extracellular production of compounds with retinoid-like activity for 50 independent cultivations of wide spectra of species including 12 cyanobacteria (15 strains) and 4 algae of different orders. Extracellular retinoidlike activity was detected for repeated cultivations of six cyanobacteria. The results were consistent for some species including Microcystis aeruginosa and Aphanizomenon gracile. The detected retinoid-like activities ranged from below the limit of quantification of 16 ng/L to over 6 mu g all-trans retinoic acid (ATRA) equivalent/L. Nontargeted virtual fractionation together with suspect screening approach enabled to identify some retinoidlike compounds in exudates, including ATRA, 9/13-cis retinoic acid, all-trans 5,6-epoxy retinoic acid, 4ketoATRA, 4keto-retinal, 4hydroxy-ATRA, and retinal. Most of them were for the first time repeatedly detected in exudates of all studied algae (at ng/L levels) and cyanobacteria. Their relative potencies ranged from 0.018 (retinal) to 1 compared to ATRA. They accounted for less than 0.1-50% of total detected retinoid-like activity. The high detected activities and concentrations of retinoids in some samples and their direct accessibility from exudates document potential risk of developmental toxicity for organisms in proximity of massive water blooms.
ER -
SMUTNÁ, Marie, Jaroslava VEČERKOVÁ, Jana PRIEBOJOVÁ, Marek PÍPAL, Martin KRAUSS a Klára HILSCHEROVÁ. Variability in retinoid-like activity of extracellular compound mixtures produced by wide spectra of phytoplankton species and contributing metabolites. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2021, roč.~414, July 2021, s.~1-10. ISSN~0304-3894. Dostupné z: https://dx.doi.org/10.1016/j.jhazmat.2021.125412.
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