Remodeling of Arctic char (Salvelinus alpinus) lipidome under a
stimulated scenario of Arctic warming

J 2021

Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming

WANG, Chao; Yufeng GONG; Fuchang DENG; Enmin DING; Jie TANG et al.

Základní údaje

Originální název

Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming

Autoři

Vydání

Global Change Biology, Hoboken, USA, Wiley, 2021, 1354-1013

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10619 Biodiversity conservation

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 13.212

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00122228

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Arctic warming; chronic temperature shifts; dynamic alterations; glycerolipids; glycerophospholipids; lipidomics; machine learning

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 9. 2021 22:37, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high-resolution mass-spectrometry-based lipidomics can provide insights into adaptive responses of organisms to a warmer environment in the Arctic and help to illustrate potential novel roles of lipids in the process of thermal adaption. In this study, we studied an ecologically and economically important species-Arctic char (Salvelinus alpinus)-with a detailed multi-tissue analysis of the lipidome in response to chronic shifts in temperature using a validated lipidomics workflow. In addition, dynamic alterations in the hepatic lipidome during the time course of shifts in temperature were also characterized. Our results showed that early life stages of Arctic char were more susceptible to variations in temperature. One-year-old Arctic char responded to chronic increases in temperature with coordinated regulation of lipids, including headgroup-specific remodeling of acyl chains in glycerophospholipids (GP) and extensive alterations in composition of lipids in membranes, such as less lyso-GPs, and more ether-GPs and sphingomyelin. Glycerolipids (e.g., triacylglycerol, TG) also participated in adaptive responses of the lipidome of Arctic char. Eight-week-old Arctic char exhibited rapid adaptive alterations of the hepatic lipidome to stepwise decreases in temperature while showing blunted responses to gradual increases in temperature, implying an inability to adapt rapidly to warmer environments. Three common phosphatidylethanolamines (PEs) (PE 36:6|PE 16:1_20:5, PE 38:7|PE 16:1_22:6, and PE 40:7|PE 18:1_22:6) were finally identified as candidate lipid biomarkers for temperature shifts via machine learning approach. Overall, this work provides additional information to a better understanding of underlying regulatory mechanisms of the lipidome of Arctic organisms in the face of near-future warming.

Návaznosti

839243, interní kód MU

Název: Finding unknown endocrine disrupting compounds through target pull-down assay filtration, effect direct analysis and ultra-high resolution mass spectrometry for a comprehensive efficient workflow (Akronym: PullEd-MS)

Investor: Evropská unie, Finding unknown endocrine disrupting compounds through target pull-down assay filtration, effect direct analysis and ultra-high resolution mass spectrometry for a comprehensive efficient workflow, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Citovat

WANG, Chao; Yufeng GONG; Fuchang DENG; Enmin DING; Jie TANG; Garry Paul CODLING; Jonathan K. CHALLIS; Derek GREEN; Jing WANG; Qiliang CHEN; Yuwei XIE; Shu SU; Zilin YANG; Jason RAINE; Paul D. JONES; Song TANG a John Paul GIESY. Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming. Global Change Biology. Hoboken, USA: Wiley, 2021, roč. 27, č. 14, s. 3282-3298. ISSN 1354-1013. Dostupné z: https://doi.org/10.1111/gcb.15638.

@article{1789404,
   author = {Wang, Chao and Gong, Yufeng and Deng, Fuchang and Ding, Enmin and Tang, Jie and Codling, Garry Paul and Challis, Jonathan K. and Green, Derek and Wang, Jing and Chen, Qiliang and Xie, Yuwei and Su, Shu and Yang, Zilin and Raine, Jason and Jones, Paul D. and Tang, Song and Giesy, John Paul},
   article_location = {Hoboken, USA},
   article_number = {14},
   doi = {https://doi.org/10.1111/gcb.15638},
   keywords = {Arctic warming; chronic temperature shifts; dynamic alterations; glycerolipids; glycerophospholipids; lipidomics; machine learning},
   language = {eng},
   issn = {1354-1013},
   journal = {Global Change Biology},
   title = {Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/gcb.15638},
   volume = {27},
   year = {2021}
}

TY  - JOUR
ID  - 1789404
AU  - Wang, Chao - Gong, Yufeng - Deng, Fuchang - Ding, Enmin - Tang, Jie - Codling, Garry Paul - Challis, Jonathan K. - Green, Derek - Wang, Jing - Chen, Qiliang - Xie, Yuwei - Su, Shu - Yang, Zilin - Raine, Jason - Jones, Paul D. - Tang, Song - Giesy, John Paul
PY  - 2021
TI  - Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming
JF  - Global Change Biology
VL  - 27
IS  - 14
SP  - 3282-3298
EP  - 3282-3298
PB  - Wiley
SN  - 13541013
KW  - Arctic warming
KW  - chronic temperature shifts
KW  - dynamic alterations
KW  - glycerolipids
KW  - glycerophospholipids
KW  - lipidomics
KW  - machine learning
UR  - https://onlinelibrary.wiley.com/doi/10.1111/gcb.15638
N2  - Arctic warming associated with global climate change poses a significant threat to populations of wildlife in the Arctic. Since lipids play a vital role in adaptation of organisms to variations in temperature, high-resolution mass-spectrometry-based lipidomics can provide insights into adaptive responses of organisms to a warmer environment in the Arctic and help to illustrate potential novel roles of lipids in the process of thermal adaption. In this study, we studied an ecologically and economically important species-Arctic char (Salvelinus alpinus)-with a detailed multi-tissue analysis of the lipidome in response to chronic shifts in temperature using a validated lipidomics workflow. In addition, dynamic alterations in the hepatic lipidome during the time course of shifts in temperature were also characterized. Our results showed that early life stages of Arctic char were more susceptible to variations in temperature. One-year-old Arctic char responded to chronic increases in temperature with coordinated regulation of lipids, including headgroup-specific remodeling of acyl chains in glycerophospholipids (GP) and extensive alterations in composition of lipids in membranes, such as less lyso-GPs, and more ether-GPs and sphingomyelin. Glycerolipids (e.g., triacylglycerol, TG) also participated in adaptive responses of the lipidome of Arctic char. Eight-week-old Arctic char exhibited rapid adaptive alterations of the hepatic lipidome to stepwise decreases in temperature while showing blunted responses to gradual increases in temperature, implying an inability to adapt rapidly to warmer environments. Three common phosphatidylethanolamines (PEs) (PE 36:6|PE 16:1_20:5, PE 38:7|PE 16:1_22:6, and PE 40:7|PE 18:1_22:6) were finally identified as candidate lipid biomarkers for temperature shifts via machine learning approach. Overall, this work provides additional information to a better understanding of underlying regulatory mechanisms of the lipidome of Arctic organisms in the face of near-future warming.
ER  -

WANG, Chao; Yufeng GONG; Fuchang DENG; Enmin DING; Jie TANG; Garry Paul CODLING; Jonathan K. CHALLIS; Derek GREEN; Jing WANG; Qiliang CHEN; Yuwei XIE; Shu SU; Zilin YANG; Jason RAINE; Paul D. JONES; Song TANG a John Paul GIESY. Remodeling of Arctic char (Salvelinus alpinus) lipidome under a stimulated scenario of Arctic warming. \textit{Global Change Biology}. Hoboken, USA: Wiley, 2021, roč.~27, č.~14, s.~3282-3298. ISSN~1354-1013. Dostupné z: https://doi.org/10.1111/gcb.15638.

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