Hepatotoxicity of the anionic surfactant linear alkylbenzene
sulphonate (LAS) in bullfrog tadpoles

J 2021

Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles

FRANCO-BELUSSI, Lilian; Monica JONES-COSTA; Raquel Fernanda SALLA; Bruno Fernando SANTOS SOUZA; Felipe Augusto PINTO VIDAL et al.

Základní údaje

Originální název

Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles

Autoři

Vydání

Chemosphere, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2021, 0045-6535

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.943

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00122237

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Surfactants; Sodium dodecylbenzene sulfonate; Hepatic melanomacrophages; Hemosiderin; Immune cells; Hepatocytes; Morphometry

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 9. 2021 12:06, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

The liver of anurans play an important role in metabolism, including detoxification, the biotransformation of molecules, and the storage of metabolites. Surfactants are part of domestic and industrial effluents. The effects of linear alkylbenzene sulfonate (LAS) on anuran liver remain unknown, however, some studies have evaluated the effects of LAS on the skin, gills, heart, testes, and liver of fishes. Here, we tested the hypothesis that LAS is hepatotoxic, promoting morphometric alterations in hepatocytes along with inflammation in the tissue, altering hepatic catabolism. We evaluated the effects of a LAS concentration that is considered environmentally safe in Brazilian inland waters on the liver of Lithobates catesbeianus tadpoles, including studies on morphology, morphometry, immunology, and metabolism. LAS exposure promoted enlargement of liver sinusoids and vacuolization of hepatocytes. Exposure to LAS also increased the area of mast cells and melanomacrophages (MMs). Additionally, LAS exposure increased hemosiderin inside MMs, suggesting alterations in the catabolism and storage of iron. Hepatocyte size increased after exposure to LAS, suggesting cytotoxic effects. Integrative analyses (i.e., morphometric, metabolic, and immunological) demonstrated hepatotoxic effects of LAS. These types of studies are key to understanding the negative effects of these substances on tadpole health, as these liver alterations impair anuran homeostasis.

Citovat

FRANCO-BELUSSI, Lilian; Monica JONES-COSTA; Raquel Fernanda SALLA; Bruno Fernando SANTOS SOUZA; Felipe Augusto PINTO VIDAL; Cristiane Ronchi OLIVEIRA; Elaine Cristina Mathias SILVA-ZACARIN; Fabio Camargo ABDALLA; Iolanda Cristina Silveir DUARTE a Classius DE OLIVEIRA. Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles. Chemosphere. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, roč. 266, March, s. 1-10. ISSN 0045-6535. Dostupné z: https://doi.org/10.1016/j.chemosphere.2020.129014.

@article{1789557,
   author = {FrancoandBelussi, Lilian and JonesandCosta, Monica and Salla, Raquel Fernanda and Santos Souza, Bruno Fernando and Pinto Vidal, Felipe Augusto and Oliveira, Cristiane Ronchi and SilvaandZacarin, Elaine Cristina Mathias and Abdalla, Fabio Camargo and Duarte, Iolanda Cristina Silveir and De Oliveira, Classius},
   article_location = {OXFORD},
   article_number = {March},
   doi = {https://doi.org/10.1016/j.chemosphere.2020.129014},
   keywords = {Surfactants; Sodium dodecylbenzene sulfonate; Hepatic melanomacrophages; Hemosiderin; Immune cells; Hepatocytes; Morphometry},
   language = {eng},
   issn = {0045-6535},
   journal = {Chemosphere},
   title = {Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles},
   url = {https://www.sciencedirect.com/science/article/pii/S0045653520332112?via%3Dihub},
   volume = {266},
   year = {2021}
}

TY  - JOUR
ID  - 1789557
AU  - Franco-Belussi, Lilian - Jones-Costa, Monica - Salla, Raquel Fernanda - Santos Souza, Bruno Fernando - Pinto Vidal, Felipe Augusto - Oliveira, Cristiane Ronchi - Silva-Zacarin, Elaine Cristina Mathias - Abdalla, Fabio Camargo - Duarte, Iolanda Cristina Silveir - De Oliveira, Classius
PY  - 2021
TI  - Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles
JF  - Chemosphere
VL  - 266
IS  - March
SP  - 1-10
EP  - 1-10
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00456535
KW  - Surfactants
KW  - Sodium dodecylbenzene sulfonate
KW  - Hepatic melanomacrophages
KW  - Hemosiderin
KW  - Immune cells
KW  - Hepatocytes
KW  - Morphometry
UR  - https://www.sciencedirect.com/science/article/pii/S0045653520332112?via%3Dihub
N2  - The liver of anurans play an important role in metabolism, including detoxification, the biotransformation of molecules, and the storage of metabolites. Surfactants are part of domestic and industrial effluents. The effects of linear alkylbenzene sulfonate (LAS) on anuran liver remain unknown, however, some studies have evaluated the effects of LAS on the skin, gills, heart, testes, and liver of fishes. Here, we tested the hypothesis that LAS is hepatotoxic, promoting morphometric alterations in hepatocytes along with inflammation in the tissue, altering hepatic catabolism. We evaluated the effects of a LAS concentration that is considered environmentally safe in Brazilian inland waters on the liver of Lithobates catesbeianus tadpoles, including studies on morphology, morphometry, immunology, and metabolism. LAS exposure promoted enlargement of liver sinusoids and vacuolization of hepatocytes. Exposure to LAS also increased the area of mast cells and melanomacrophages (MMs). Additionally, LAS exposure increased hemosiderin inside MMs, suggesting alterations in the catabolism and storage of iron. Hepatocyte size increased after exposure to LAS, suggesting cytotoxic effects. Integrative analyses (i.e., morphometric, metabolic, and immunological) demonstrated hepatotoxic effects of LAS. These types of studies are key to understanding the negative effects of these substances on tadpole health, as these liver alterations impair anuran homeostasis.
ER  -

FRANCO-BELUSSI, Lilian; Monica JONES-COSTA; Raquel Fernanda SALLA; Bruno Fernando SANTOS SOUZA; Felipe Augusto PINTO VIDAL; Cristiane Ronchi OLIVEIRA; Elaine Cristina Mathias SILVA-ZACARIN; Fabio Camargo ABDALLA; Iolanda Cristina Silveir DUARTE a Classius DE OLIVEIRA. Hepatotoxicity of the anionic surfactant linear alkylbenzene sulphonate (LAS) in bullfrog tadpoles. \textit{Chemosphere}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, roč.~266, March, s.~1-10. ISSN~0045-6535. Dostupné z: https://doi.org/10.1016/j.chemosphere.2020.129014.

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