Intrinsic atomic interaction at molecular proximal vicinity
infer cellular biocompatibility of antibacterial nanopepper

J 2021

Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper

JHA, Ealisha; Pritam Kumar PANDA; Paritosh PATEL; Puja KUMARI; Swabhiman MOHANTY et al.

Základní údaje

Originální název

Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper

Autoři

JHA, Ealisha; Pritam Kumar PANDA; Paritosh PATEL; Puja KUMARI; Swabhiman MOHANTY; S.K.S. PARASHAR; Rajeev AHUJA; Suresh K. VERMA a Mrutyunjay SUAR

Vydání

NANOMEDICINE, LONDON, FUTURE MEDICINE LTD, 2021, 1743-5889

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

21000 2.10 Nano-technology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.096

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00122253

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

antibacterial; black pepper; caspase; cytotoxicity; HCT116 cells; piperine; Sod1

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 9. 2021 21:35, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Aim: Fabrication of nanopepper (NP) for antibacterial application and elucidation of its molecular and cellular biocompatibility. Materials & methods: Synthesis of NP was achieved using a high-energy ball milling method. Following characterization, its antibacterial activity and cellular and molecular biocompatibility were evaluated in vitro by experimental and computational approaches. Results: A total of 15 h of milling pepper produced NP with a size of 44 +/- 12 nm and zeta potential of -22 +/- 12 mV. Bulk pepper and NP showed antibacterial activity and an LC50 of 1.9 mu M and 2.1 mu M in HCT116 colon cells. Components of pepper, piperine and beta-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds. Conclusion: NP exhibits significant antibacterial activity with cellular biocompatibility due to intrinsic atomic interaction.

Citovat

JHA, Ealisha; Pritam Kumar PANDA; Paritosh PATEL; Puja KUMARI; Swabhiman MOHANTY; S.K.S. PARASHAR; Rajeev AHUJA; Suresh K. VERMA a Mrutyunjay SUAR. Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper. NANOMEDICINE. LONDON: FUTURE MEDICINE LTD, 2021, roč. 16, č. 4, s. 307-322. ISSN 1743-5889. Dostupné z: https://doi.org/10.2217/nnm-2020-0395.

@article{1789780,
   author = {Jha, Ealisha and Panda, Pritam Kumar and Patel, Paritosh and Kumari, Puja and Mohanty, Swabhiman and Parashar, S.K.S. and Ahuja, Rajeev and Verma, Suresh K. and Suar, Mrutyunjay},
   article_location = {LONDON},
   article_number = {4},
   doi = {https://doi.org/10.2217/nnm-2020-0395},
   keywords = {antibacterial; black pepper; caspase; cytotoxicity; HCT116 cells; piperine; Sod1},
   language = {eng},
   issn = {1743-5889},
   journal = {NANOMEDICINE},
   title = {Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper},
   url = {https://www.futuremedicine.com/doi/10.2217/nnm-2020-0395},
   volume = {16},
   year = {2021}
}

TY  - JOUR
ID  - 1789780
AU  - Jha, Ealisha - Panda, Pritam Kumar - Patel, Paritosh - Kumari, Puja - Mohanty, Swabhiman - Parashar, S.K.S. - Ahuja, Rajeev - Verma, Suresh K. - Suar, Mrutyunjay
PY  - 2021
TI  - Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper
JF  - NANOMEDICINE
VL  - 16
IS  - 4
SP  - 307-322
EP  - 307-322
PB  - FUTURE MEDICINE LTD
SN  - 17435889
KW  - antibacterial
KW  - black pepper
KW  - caspase
KW  - cytotoxicity
KW  - HCT116 cells
KW  - piperine
KW  - Sod1
UR  - https://www.futuremedicine.com/doi/10.2217/nnm-2020-0395
N2  - Aim: Fabrication of nanopepper (NP) for antibacterial application and elucidation of its molecular and cellular biocompatibility. Materials & methods: Synthesis of NP was achieved using a high-energy ball milling method. Following characterization, its antibacterial activity and cellular and molecular biocompatibility were evaluated in vitro by experimental and computational approaches. Results: A total of 15 h of milling pepper produced NP with a size of 44 +/- 12 nm and zeta potential of -22 +/- 12 mV. Bulk pepper and NP showed antibacterial activity and an LC50 of 1.9 mu M and 2.1 mu M in HCT116 colon cells. Components of pepper, piperine and beta-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds. Conclusion: NP exhibits significant antibacterial activity with cellular biocompatibility due to intrinsic atomic interaction.
ER  -

JHA, Ealisha; Pritam Kumar PANDA; Paritosh PATEL; Puja KUMARI; Swabhiman MOHANTY; S.K.S. PARASHAR; Rajeev AHUJA; Suresh K. VERMA a Mrutyunjay SUAR. Intrinsic atomic interaction at molecular proximal vicinity infer cellular biocompatibility of antibacterial nanopepper. \textit{NANOMEDICINE}. LONDON: FUTURE MEDICINE LTD, 2021, roč.~16, č.~4, s.~307-322. ISSN~1743-5889. Dostupné z: https://doi.org/10.2217/nnm-2020-0395.

Přehled o publikaci