NAChRDB: A Web Resource of Structure–Function Annotations to
Unravel the Allostery of Nicotinic Acetylcholine Receptors

J 2021

NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors

CHARESHNEU, Aliaksei; Purbaj PANT; Ravi José Tristao RAMOS; David SEHNAL; Tuğrul GÖKBEL et al.

Základní údaje

Originální název

NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors

Autoři

CHARESHNEU, Aliaksei; Purbaj PANT; Ravi José Tristao RAMOS; David SEHNAL; Tuğrul GÖKBEL; Crina-Maria IONESCU a Jaroslav KOČA

Vydání

ACS Omega, American Chemical Society, 2021, 2470-1343

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.132

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/21:00122276

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Amines; Biological databases; Chemical structure; Sequence alignment; Receptors

Štítky

143160, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 2. 2022 13:12, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Nicotinic acetylcholine receptors (nAChRs) comprise a large and ancient family of allosteric ion channels mediating synaptic transmission. The vast knowledge about nAChRs has become difficult to navigate. NAChRDB is a web-accessible resource of curated residue-level functional annotations of neuromuscular nAChRs. Interactive three-dimensional (3D) visualization and sequence alignment give further context to this rich and growing collection of experimental observations and computational predictions. NAChRDB is freely available at https://crocodile.ncbr.muni.cz/Apps/NAChRDB/, with interactive tutorials and regular updates to the content and web interface. No installation or user registration is required. NAChRDB is accessible through any modern internet browser on desktops and mobile devices. By providing immediate and systematic access to practical knowledge gained through decades of research, NAChRDB represents a powerful educational tool and helps guide discovery by revealing gaps in current knowledge and aiding the interpretation of results of molecular and structural biology experiments or computational studies.

Návaznosti

LM2018131, projekt VaV

Název: Česká národní infrastruktura pro biologická data (Akronym: ELIXIR-CZ)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Česká národní infrastruktura pro biologická data

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

CHARESHNEU, Aliaksei; Purbaj PANT; Ravi José Tristao RAMOS; David SEHNAL; Tuğrul GÖKBEL; Crina-Maria IONESCU a Jaroslav KOČA. NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors. ACS Omega. American Chemical Society, 2021, roč. 6, č. 36, s. 23023-23027. ISSN 2470-1343. Dostupné z: https://doi.org/10.1021/acsomega.1c00817.

@article{1790264,
   author = {Chareshneu, Aliaksei and Pant, Purbaj and Ramos, Ravi José Tristao and Sehnal, David and Gökbel, Tuğrul and Ionescu, CrinaandMaria and Koča, Jaroslav},
   article_number = {36},
   doi = {https://doi.org/10.1021/acsomega.1c00817},
   keywords = {Amines; Biological databases; Chemical structure; Sequence alignment; Receptors},
   language = {eng},
   issn = {2470-1343},
   journal = {ACS Omega},
   title = {NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors},
   url = {https://pubs.acs.org/doi/10.1021/acsomega.1c00817},
   volume = {6},
   year = {2021}
}

TY  - JOUR
ID  - 1790264
AU  - Chareshneu, Aliaksei - Pant, Purbaj - Ramos, Ravi José Tristao - Sehnal, David - Gökbel, Tuğrul - Ionescu, Crina-Maria - Koča, Jaroslav
PY  - 2021
TI  - NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors
JF  - ACS Omega
VL  - 6
IS  - 36
SP  - 23023-23027
EP  - 23023-23027
PB  - American Chemical Society
SN  - 24701343
KW  - Amines
KW  - Biological databases
KW  - Chemical structure
KW  - Sequence alignment
KW  - Receptors
UR  - https://pubs.acs.org/doi/10.1021/acsomega.1c00817
N2  - Nicotinic acetylcholine receptors (nAChRs) comprise a large and ancient family of allosteric ion channels mediating synaptic transmission. The vast knowledge about nAChRs has become difficult to navigate. NAChRDB is a web-accessible resource of curated residue-level functional annotations of neuromuscular nAChRs. Interactive three-dimensional (3D) visualization and sequence alignment give further context to this rich and growing collection of experimental observations and computational predictions. NAChRDB is freely available at https://crocodile.ncbr.muni.cz/Apps/NAChRDB/, with interactive tutorials and regular updates to the content and web interface. No installation or user registration is required. NAChRDB is accessible through any modern internet browser on desktops and mobile devices. By providing immediate and systematic access to practical knowledge gained through decades of research, NAChRDB represents a powerful educational tool and helps guide discovery by revealing gaps in current knowledge and aiding the interpretation of results of molecular and structural biology experiments or computational studies.
ER  -

CHARESHNEU, Aliaksei; Purbaj PANT; Ravi José Tristao RAMOS; David SEHNAL; Tuğrul GÖKBEL; Crina-Maria IONESCU a Jaroslav KOČA. NAChRDB: A Web Resource of Structure–Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors. \textit{ACS Omega}. American Chemical Society, 2021, roč.~6, č.~36, s.~23023-23027. ISSN~2470-1343. Dostupné z: https://doi.org/10.1021/acsomega.1c00817.

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