Empagliflozin in Heart Failure with a Preserved Ejection
Fraction

J 2021

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

ANKER, S.D., J. BUTLER, G. FILIPPATOS, J. P. FERREIRA, E. BOCCHI et. al.

Základní údaje

Originální název

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Autoři

ANKER, S.D. (garant), J. BUTLER, G. FILIPPATOS, J. P. FERREIRA, E. BOCCHI, M. BOHM, Rocca H. P. BRUNNER-LA, D. J. CHOI, V. CHOPRA, E. CHUQUIURE-VALENZUELA, N. GIANNETTI, J. E. GOMEZ-MESA, S. JANSSENS, J. L. JANUZZI, J. R. GONZALEZ-JUANATEY, B. MERKELY, S. J. NICHOLLS, S. V. PERRONE, I. L. PINA, P. PONIKOWSKI, M. SENNI, D. SIM, Jindřich ŠPINAR (203 Česká republika, domácí), I. SQUIRE, S. TADDEI, H. TSUTSUI, S. VERMA, D. VINEREANU, J. ZHANG, P. CARSON, C. S. P. LAM, N. MARX, C. ZELLER, N. SATTAR, W. JAMAL, S. SCHNAIDT, J. M. SCHNEE, M. BRUECKMANN, S. J. POCOCK, F. ZANNAD a M. PACKER

Vydání

New England Journal of Medicine, Waltham, Massachussetts Medical Society, 2021, 0028-4793

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Slovinsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 176.079

Kód RIV

RIV/00216224:14110/21:00122279

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1056/NEJMoa2107038

UT WoS

000691622000001

Klíčová slova anglicky

Heart Failure; Empagliflozin; Preserved Ejection Fraction

Štítky

14110115, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 12. 2021 10:49, Mgr. Tereza Miškechová

Anotace

V originále

BACKGROUND Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. METHODS In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. RESULTS Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P<0.001). This effect was mainly related to a lower risk of hospitalization for heart failure in the empagliflozin group. The effects of empagliflozin appeared consistent in patients with or without diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (407 with empagliflozin and 541 with placebo; hazard ratio, 0.73; 95% CI, 0.61 to 0.88; P<0.001). Uncomplicated genital and urinary tract infections and hypotension were reported more frequently with empagliflozin. CONCLUSIONS Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.

Citovat

ANKER, S.D., J. BUTLER, G. FILIPPATOS, J. P. FERREIRA, E. BOCCHI, M. BOHM, Rocca H. P. BRUNNER-LA, D. J. CHOI, V. CHOPRA, E. CHUQUIURE-VALENZUELA, N. GIANNETTI, J. E. GOMEZ-MESA, S. JANSSENS, J. L. JANUZZI, J. R. GONZALEZ-JUANATEY, B. MERKELY, S. J. NICHOLLS, S. V. PERRONE, I. L. PINA, P. PONIKOWSKI, M. SENNI, D. SIM, Jindřich ŠPINAR, I. SQUIRE, S. TADDEI, H. TSUTSUI, S. VERMA, D. VINEREANU, J. ZHANG, P. CARSON, C. S. P. LAM, N. MARX, C. ZELLER, N. SATTAR, W. JAMAL, S. SCHNAIDT, J. M. SCHNEE, M. BRUECKMANN, S. J. POCOCK, F. ZANNAD a M. PACKER. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. New England Journal of Medicine. Waltham: Massachussetts Medical Society, 2021, roč. 385, č. 16, s. 1451-1461. ISSN 0028-4793. Dostupné z: https://dx.doi.org/10.1056/NEJMoa2107038.

@article{1790339,
   author = {Anker, S.D. and Butler, J. and Filippatos, G. and Ferreira, J. P. and Bocchi, E. and Bohm, M. and BrunnerandLa, Rocca H. P. and Choi, D. J. and Chopra, V. and ChuquiureandValenzuela, E. and Giannetti, N. and GomezandMesa, J. E. and Janssens, S. and Januzzi, J. L. and GonzalezandJuanatey, J. R. and Merkely, B. and Nicholls, S. J. and Perrone, S. V. and Pina, I. L. and Ponikowski, P. and Senni, M. and Sim, D. and Špinar, Jindřich and Squire, I. and Taddei, S. and Tsutsui, H. and Verma, S. and Vinereanu, D. and Zhang, J. and Carson, P. and Lam, C. S. P. and Marx, N. and Zeller, C. and Sattar, N. and Jamal, W. and Schnaidt, S. and Schnee, J. M. and Brueckmann, M. and Pocock, S. J. and Zannad, F. and Packer, M.},
   article_location = {Waltham},
   article_number = {16},
   doi = {http://dx.doi.org/10.1056/NEJMoa2107038},
   keywords = {Heart Failure; Empagliflozin; Preserved Ejection Fraction},
   language = {eng},
   issn = {0028-4793},
   journal = {New England Journal of Medicine},
   title = {Empagliflozin in Heart Failure with a Preserved Ejection Fraction},
   url = {https://www.nejm.org/doi/10.1056/NEJMoa2107038},
   volume = {385},
   year = {2021}
}

TY  - JOUR
ID  - 1790339
AU  - Anker, S.D. - Butler, J. - Filippatos, G. - Ferreira, J. P. - Bocchi, E. - Bohm, M. - Brunner-La, Rocca H. P. - Choi, D. J. - Chopra, V. - Chuquiure-Valenzuela, E. - Giannetti, N. - Gomez-Mesa, J. E. - Janssens, S. - Januzzi, J. L. - Gonzalez-Juanatey, J. R. - Merkely, B. - Nicholls, S. J. - Perrone, S. V. - Pina, I. L. - Ponikowski, P. - Senni, M. - Sim, D. - Špinar, Jindřich - Squire, I. - Taddei, S. - Tsutsui, H. - Verma, S. - Vinereanu, D. - Zhang, J. - Carson, P. - Lam, C. S. P. - Marx, N. - Zeller, C. - Sattar, N. - Jamal, W. - Schnaidt, S. - Schnee, J. M. - Brueckmann, M. - Pocock, S. J. - Zannad, F. - Packer, M.
PY  - 2021
TI  - Empagliflozin in Heart Failure with a Preserved Ejection Fraction
JF  - New England Journal of Medicine
VL  - 385
IS  - 16
SP  - 1451-1461
EP  - 1451-1461
PB  - Massachussetts Medical Society
SN  - 00284793
KW  - Heart Failure
KW  - Empagliflozin
KW  - Preserved Ejection Fraction
UR  - https://www.nejm.org/doi/10.1056/NEJMoa2107038
N2  - BACKGROUND Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. METHODS In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. RESULTS Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P<0.001). This effect was mainly related to a lower risk of hospitalization for heart failure in the empagliflozin group. The effects of empagliflozin appeared consistent in patients with or without diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (407 with empagliflozin and 541 with placebo; hazard ratio, 0.73; 95% CI, 0.61 to 0.88; P<0.001). Uncomplicated genital and urinary tract infections and hypotension were reported more frequently with empagliflozin. CONCLUSIONS Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.
ER  -

ANKER, S.D., J. BUTLER, G. FILIPPATOS, J. P. FERREIRA, E. BOCCHI, M. BOHM, Rocca H. P. BRUNNER-LA, D. J. CHOI, V. CHOPRA, E. CHUQUIURE-VALENZUELA, N. GIANNETTI, J. E. GOMEZ-MESA, S. JANSSENS, J. L. JANUZZI, J. R. GONZALEZ-JUANATEY, B. MERKELY, S. J. NICHOLLS, S. V. PERRONE, I. L. PINA, P. PONIKOWSKI, M. SENNI, D. SIM, Jindřich ŠPINAR, I. SQUIRE, S. TADDEI, H. TSUTSUI, S. VERMA, D. VINEREANU, J. ZHANG, P. CARSON, C. S. P. LAM, N. MARX, C. ZELLER, N. SATTAR, W. JAMAL, S. SCHNAIDT, J. M. SCHNEE, M. BRUECKMANN, S. J. POCOCK, F. ZANNAD a M. PACKER. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. \textit{New England Journal of Medicine}. Waltham: Massachussetts Medical Society, 2021, roč.~385, č.~16, s.~1451-1461. ISSN~0028-4793. Dostupné z: https://dx.doi.org/10.1056/NEJMoa2107038.

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