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@article{1794937, author = {Kohelova, E. and Marikova, J. and Korabecny, J. and Hulcova, D. and Kucera, T. and Jun, D. and Chlebek, J. and Jenco, J. and Safratova, M. and Hrabinova, M. and Ritomska, A. and Malaník, Milan and Perinova, R. and Breiterova, K. and Kunes, J. and Novakova, L. and Opletal, L. and Cahlikova, L.}, article_location = {SAN DIEGO}, article_number = {104567}, doi = {http://dx.doi.org/10.1016/j.bioorg.2020.104567}, keywords = {Zephyranthes citrina; Amaryllidaceae; Alkaloids; Narcieliine; Alzheimer's disease; Docking studies}, language = {eng}, issn = {0045-2068}, journal = {Bioorganic Chemistry}, title = {Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity}, url = {https://reader.elsevier.com/reader/sd/pii/S0045206820318654?token=5E47B1A8AADF6BF05D1AAF363BAF7C93AC087C9BDDAE841A51EAC2BBE4E3BF467F787C1AC7BE0F078B20D8FC896C9179&originRegion=eu-west-1&originCreation=20210930052405}, volume = {107}, year = {2021} }
TY - JOUR ID - 1794937 AU - Kohelova, E. - Marikova, J. - Korabecny, J. - Hulcova, D. - Kucera, T. - Jun, D. - Chlebek, J. - Jenco, J. - Safratova, M. - Hrabinova, M. - Ritomska, A. - Malaník, Milan - Perinova, R. - Breiterova, K. - Kunes, J. - Novakova, L. - Opletal, L. - Cahlikova, L. PY - 2021 TI - Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity JF - Bioorganic Chemistry VL - 107 IS - 104567 SP - 1-11 EP - 1-11 PB - ACADEMIC PRESS INC ELSEVIER SCIENCE SN - 00452068 KW - Zephyranthes citrina KW - Amaryllidaceae KW - Alkaloids KW - Narcieliine KW - Alzheimer's disease KW - Docking studies UR - https://reader.elsevier.com/reader/sd/pii/S0045206820318654?token=5E47B1A8AADF6BF05D1AAF363BAF7C93AC087C9BDDAE841A51EAC2BBE4E3BF467F787C1AC7BE0F078B20D8FC896C9179&originRegion=eu-west-1&originCreation=20210930052405 N2 - Twenty known Amaryllidaceae alkaloids of various structural types, and one undescribed alkaloid of narcikachnine-type, named narcieliine (3), have been isolated from fresh bulbs of Zephyranthes citrina. The chemical structures of the isolated alkaloids were elucidated by a combination of MS, HRMS, 1D and 2D NMR, and CD spectroscopic techniques, and by comparison with literature data. The absolute configuration of narcieliine (3) has also been determined. Compounds isolated in a sufficient quantity were evaluated for their in vitro acetylcholinesterase (AChE; E.C. 3.1.1.7), butyrylcholinesterase (BuChE; E.C. 3.1.1.8), and prolyl oligopeptidase (POP; E.C. 3.4.21.26) inhibition activities. Significant human AChE/BuChE (hAChE/hBuChE) inhibitory activity was demonstrated by the newly described alkaloid narcieliine (3), with IC50 values of 18.7 +/- 2.3 mu M and 1.34 +/- 0.31 mu M, respectively. This compound is also predicted to cross the blood-brain barrier (BBB) through passive diffusion. The in vitro data were further supported by in silico studies of 3 in the active site of hAChE/hBuChE. ER -
KOHELOVA, E., J. MARIKOVA, J. KORABECNY, D. HULCOVA, T. KUCERA, D. JUN, J. CHLEBEK, J. JENCO, M. SAFRATOVA, M. HRABINOVA, A. RITOMSKA, Milan MALANÍK, R. PERINOVA, K. BREITEROVA, J. KUNES, L. NOVAKOVA, L. OPLETAL a L. CAHLIKOVA. Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity. \textit{Bioorganic Chemistry}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2021, roč.~107, č.~104567, s.~1-11. ISSN~0045-2068. Dostupné z: https://dx.doi.org/10.1016/j.bioorg.2020.104567.
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