Radiation-Induced Changes in Ventricular Myocardium After
Stereotactic Body Radiotherapy for Recurrent Ventricular
Tachycardia

J 2021

Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia

KAUTZNER, Josef, Kristina JEDLICKOVA, Marek SRAMKO, Petr PEICHL, Jakub CVEK et. al.

Základní údaje

Originální název

Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia

Autoři

KAUTZNER, Josef (203 Česká republika, garant), Kristina JEDLICKOVA (203 Česká republika), Marek SRAMKO (203 Česká republika), Petr PEICHL (203 Česká republika), Jakub CVEK (203 Česká republika), Lukas KNYBEL (203 Česká republika), Radek NEUWIRTH (203 Česká republika, domácí), Otakar JIRAVSKÝ (203 Česká republika, domácí), Ludek VOSKA (203 Česká republika) a Tomas KUCERA (203 Česká republika)

Vydání

JACC: Clinical Electrophysiology, Amsterdam, Elsevier, 2021, 2405-500X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.124

Kód RIV

RIV/00216224:14110/21:00122490

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jacep.2021.07.012

UT WoS

000744196000003

Klíčová slova anglicky

catheter ablation; histology; immunohistochemistry; radiotherapy; ventricular tachycardia

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 4. 2022 10:18, Mgr. Tereza Miškechová

Anotace

V originále

Stereotactic body radiotherapy (SBRT) has been suggested as a promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. This case series is the first postmortem immunohistochemical analysis of morphologic changes in the myocardium early and late after SBRT. The present findings are in line with experimental observations on apoptosis followed by fibrosis. This may explain why the effect of SBRT on VT is not predominantly immediate. Together with observation of early recurrences after SBRT for VT, these data suggest that this strategy may have rather delayed antiarrhythmic effects. (J Am Coll Cardiol EP 2021;7:1487-1492) (c) 2021 by the American College of Cardiology Foundation.

Citovat

KAUTZNER, Josef, Kristina JEDLICKOVA, Marek SRAMKO, Petr PEICHL, Jakub CVEK, Lukas KNYBEL, Radek NEUWIRTH, Otakar JIRAVSKÝ, Ludek VOSKA a Tomas KUCERA. Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia. JACC: Clinical Electrophysiology. Amsterdam: Elsevier, 2021, roč. 7, č. 12, s. 1487-1492. ISSN 2405-500X. Dostupné z: https://dx.doi.org/10.1016/j.jacep.2021.07.012.

@article{1795399,
   author = {Kautzner, Josef and Jedlickova, Kristina and Sramko, Marek and Peichl, Petr and Cvek, Jakub and Knybel, Lukas and Neuwirth, Radek and Jiravský, Otakar and Voska, Ludek and Kucera, Tomas},
   article_location = {Amsterdam},
   article_number = {12},
   doi = {http://dx.doi.org/10.1016/j.jacep.2021.07.012},
   keywords = {catheter ablation; histology; immunohistochemistry; radiotherapy; ventricular tachycardia},
   language = {eng},
   issn = {2405-500X},
   journal = {JACC: Clinical Electrophysiology},
   title = {Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia},
   url = {http://sciencedirect.com/science/article/abs/pii/S2405500X21006873?via%3Dihub#!},
   volume = {7},
   year = {2021}
}

TY  - JOUR
ID  - 1795399
AU  - Kautzner, Josef - Jedlickova, Kristina - Sramko, Marek - Peichl, Petr - Cvek, Jakub - Knybel, Lukas - Neuwirth, Radek - Jiravský, Otakar - Voska, Ludek - Kucera, Tomas
PY  - 2021
TI  - Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia
JF  - JACC: Clinical Electrophysiology
VL  - 7
IS  - 12
SP  - 1487-1492
EP  - 1487-1492
PB  - Elsevier
SN  - 2405500X
KW  - catheter ablation
KW  - histology
KW  - immunohistochemistry
KW  - radiotherapy
KW  - ventricular tachycardia
UR  - http://sciencedirect.com/science/article/abs/pii/S2405500X21006873?via%3Dihub#!
N2  - Stereotactic body radiotherapy (SBRT) has been suggested as a promising therapeutic alternative in cases of failed catheter ablation for recurrent ventricular tachycardias (VTs) in patients with structural heart disease. This case series is the first postmortem immunohistochemical analysis of morphologic changes in the myocardium early and late after SBRT. The present findings are in line with experimental observations on apoptosis followed by fibrosis. This may explain why the effect of SBRT on VT is not predominantly immediate. Together with observation of early recurrences after SBRT for VT, these data suggest that this strategy may have rather delayed antiarrhythmic effects. (J Am Coll Cardiol EP 2021;7:1487-1492) (c) 2021 by the American College of Cardiology Foundation.
ER  -

KAUTZNER, Josef, Kristina JEDLICKOVA, Marek SRAMKO, Petr PEICHL, Jakub CVEK, Lukas KNYBEL, Radek NEUWIRTH, Otakar JIRAVSKÝ, Ludek VOSKA a Tomas KUCERA. Radiation-Induced Changes in Ventricular Myocardium After Stereotactic Body Radiotherapy for Recurrent Ventricular Tachycardia. \textit{JACC: Clinical Electrophysiology}. Amsterdam: Elsevier, 2021, roč.~7, č.~12, s.~1487-1492. ISSN~2405-500X. Dostupné z: https://dx.doi.org/10.1016/j.jacep.2021.07.012.

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