| RAŠKA, Jan, Hana HŘÍBKOVÁ, Hana KLÍMOVÁ, Veronika FEDOROVÁ, Martin BARÁK, Tomáš BÁRTA, Veronika POSPÍŠILOVÁ, Simona VOCHYÁNOVÁ, Tereza VÁŇOVÁ a Dáša BOHAČIAKOVÁ. Generation of six human iPSC lines from patients with a familial Alzheimer's disease (n=3) and sex- and age-matched healthy controls (n=3). Stem cell research. Amsterdam: Elsevier, 2021, roč. 53, May 2021, s. 1-5. ISSN 1873-5061. Dostupné z: https://dx.doi.org/10.1016/j.scr.2021.102379. |
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@article{1801106,
author = {Raška, Jan and Hříbková, Hana and Klímová, Hana and Fedorová, Veronika and Barák, Martin and Bárta, Tomáš and Pospíšilová, Veronika and Vochyánová, Simona and Váňová, Tereza and Bohačiaková, Dáša},
article_location = {Amsterdam},
article_number = {May 2021},
doi = {http://dx.doi.org/10.1016/j.scr.2021.102379},
keywords = {six human iPSC lines; Alzheimer's disease; healthy controls},
language = {eng},
issn = {1873-5061},
journal = {Stem cell research},
title = {Generation of six human iPSC lines from patients with a familial Alzheimer's disease (n=3) and sex- and age-matched healthy controls (n=3)},
url = {https://www.sciencedirect.com/science/article/pii/S1873506121002257?via%3Dihub#!},
volume = {53},
year = {2021}
}
TY - JOUR
ID - 1801106
AU - Raška, Jan - Hříbková, Hana - Klímová, Hana - Fedorová, Veronika - Barák, Martin - Bárta, Tomáš - Pospíšilová, Veronika - Vochyánová, Simona - Váňová, Tereza - Bohačiaková, Dáša
PY - 2021
TI - Generation of six human iPSC lines from patients with a familial Alzheimer's disease (n=3) and sex- and age-matched healthy controls (n=3)
JF - Stem cell research
VL - 53
IS - May 2021
SP - 1-5
EP - 1-5
PB - Elsevier
SN - 18735061
KW - six human iPSC lines
KW - Alzheimer's disease
KW - healthy controls
UR - https://www.sciencedirect.com/science/article/pii/S1873506121002257?via%3Dihub#!
N2 - Human induced pluripotent stem cell (iPSC) lines were generated from primary human fibroblasts isolated from three patients with a familial form of Alzheimer's disease (AD) and three healthy control individuals. Two AD-iPSC lines carry a PSEN1 mutation A246E; the third cell line carries a PSEN2 mutation N141I. The fibroblasts were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5 Reprogramming Kit. The pluripotency of iPSCs was confirmed by the expression of pluripotency factors and by their ability to differentiate to all three germ layers in vitro. Newly derived cell lines can be used to model Alzheimer's disease in vitro.
ER -
RAŠKA, Jan, Hana HŘÍBKOVÁ, Hana KLÍMOVÁ, Veronika FEDOROVÁ, Martin BARÁK, Tomáš BÁRTA, Veronika POSPÍŠILOVÁ, Simona VOCHYÁNOVÁ, Tereza VÁŇOVÁ a Dáša BOHAČIAKOVÁ. Generation of six human iPSC lines from patients with a familial Alzheimer's disease (n=3) and sex- and age-matched healthy controls (n=3). \textit{Stem cell research}. Amsterdam: Elsevier, 2021, roč.~53, May 2021, s.~1-5. ISSN~1873-5061. Dostupné z: https://dx.doi.org/10.1016/j.scr.2021.102379.
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