Differentiating Primary Sclerosing Cholangitis from Similar
Diseases of Autoimmune Origin

J 2021

Differentiating Primary Sclerosing Cholangitis from Similar Diseases of Autoimmune Origin

KUNOVSKÝ, Lumír, Petr DITE, Ľubomíra HORŇÁKOVÁ, Jiří DOLINA, Magdalena UVIROVA et. al.

Základní údaje

Originální název

Differentiating Primary Sclerosing Cholangitis from Similar Diseases of Autoimmune Origin

Autoři

KUNOVSKÝ, Lumír (203 Česká republika, garant, domácí), Petr DITE (203 Česká republika), Ľubomíra HORŇÁKOVÁ (703 Slovensko, domácí), Jiří DOLINA (203 Česká republika, domácí), Magdalena UVIROVA (203 Česká republika), Vladimír KOJECKÝ (203 Česká republika, domácí), Arnost MARTINEK (203 Česká republika) a Petr JABANDŽIEV (203 Česká republika, domácí)

Vydání

Journal of Gastrointestinal and Liver Diseases, CLUJ-NAPOCA, MEDICAL UNIV PRESS, 2021, 1841-8724

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Rumunsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.142

Kód RIV

RIV/00216224:14110/21:00122809

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.15403/jgld-3849

UT WoS

000701282100014

Klíčová slova anglicky

autoimmune diseases; IgG4-related sclerosing cholangitis; primary sclerosing cholangitis; primary sclerosing cholangitis with increased IgG4

Štítky

14110213, 14110223, 14110317, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 3. 2022 07:20, Mgr. Tereza Miškechová

Anotace

V originále

Background & Aims: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease. Differential diagnostics can confuse it with immunoglobulin (Ig) G4-related sclerosing cholangitis (SC), an IgG4-related disease with clearly proven autoimmune origin. Differential diagnosis is made even more challenging because PSC with increased IgG4 levels (PSC-increased IgG4) also occurs. In order to facilitate their differential diagnosis, we reviewed recent literature regarding the etiologies, identifying characteristics, the most useful diagnostics, treatment, and the progression of these partially similar diseases. It is clear that PSC's pathogenesis differs from that of IgG4-related SC. In any differential diagnosis between PSC and PSC-increased IgG4, high IgG1 and low or normal IgG2 levels are characteristic for patients with PSC. Histological examination of the biliary tree wall in patients with IgG4-related SC typically reveals such changes as storiform fibrosis, obliterative phlebitis, and venulitis. These are absent in PSC-increased IgG4, which is characterized by a typical circular thickness in different parts of the biliary ducts. Finally, PSC is associated with inflammatory bowel disease, which is rare in IgG4-related SC, and more frequently is associated with cholangiocarcinomas and colon cancers. As distinct from IgG4-related SC, PSC is not a primary autoimmune disease.

Citovat

KUNOVSKÝ, Lumír, Petr DITE, Ľubomíra HORŇÁKOVÁ, Jiří DOLINA, Magdalena UVIROVA, Vladimír KOJECKÝ, Arnost MARTINEK a Petr JABANDŽIEV. Differentiating Primary Sclerosing Cholangitis from Similar Diseases of Autoimmune Origin. Journal of Gastrointestinal and Liver Diseases. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, roč. 30, č. 3, s. 398-403. ISSN 1841-8724. Dostupné z: https://dx.doi.org/10.15403/jgld-3849.

@article{1802366,
   author = {Kunovský, Lumír and Dite, Petr and Horňáková, Ľubomíra and Dolina, Jiří and Uvirova, Magdalena and Kojecký, Vladimír and Martinek, Arnost and Jabandžiev, Petr},
   article_location = {CLUJ-NAPOCA},
   article_number = {3},
   doi = {http://dx.doi.org/10.15403/jgld-3849},
   keywords = {autoimmune diseases; IgG4-related sclerosing cholangitis; primary sclerosing cholangitis; primary sclerosing cholangitis with increased IgG4},
   language = {eng},
   issn = {1841-8724},
   journal = {Journal of Gastrointestinal and Liver Diseases},
   title = {Differentiating Primary Sclerosing Cholangitis from Similar Diseases of Autoimmune Origin},
   url = {https://www.jgld.ro/jgld/index.php/jgld/article/view/3849/1760},
   volume = {30},
   year = {2021}
}

TY  - JOUR
ID  - 1802366
AU  - Kunovský, Lumír - Dite, Petr - Horňáková, Ľubomíra - Dolina, Jiří - Uvirova, Magdalena - Kojecký, Vladimír - Martinek, Arnost - Jabandžiev, Petr
PY  - 2021
TI  - Differentiating Primary Sclerosing Cholangitis from Similar Diseases of Autoimmune Origin
JF  - Journal of Gastrointestinal and Liver Diseases
VL  - 30
IS  - 3
SP  - 398-403
EP  - 398-403
PB  - MEDICAL UNIV PRESS
SN  - 18418724
KW  - autoimmune diseases
KW  -
KW  - IgG4-related sclerosing cholangitis
KW  -
KW  - primary sclerosing cholangitis
KW  -
KW  - primary sclerosing cholangitis with increased IgG4
UR  - https://www.jgld.ro/jgld/index.php/jgld/article/view/3849/1760
N2  - Background & Aims: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease. Differential diagnostics can confuse it with immunoglobulin (Ig) G4-related sclerosing cholangitis (SC), an IgG4-related disease with clearly proven autoimmune origin. Differential diagnosis is made even more challenging because PSC with increased IgG4 levels (PSC-increased IgG4) also occurs. In order to facilitate their differential diagnosis, we reviewed recent literature regarding the etiologies, identifying characteristics, the most useful diagnostics, treatment, and the progression of these partially similar diseases. It is clear that PSC's pathogenesis differs from that of IgG4-related SC. In any differential diagnosis between PSC and PSC-increased IgG4, high IgG1 and low or normal IgG2 levels are characteristic for patients with PSC. Histological examination of the biliary tree wall in patients with IgG4-related SC typically reveals such changes as storiform fibrosis, obliterative phlebitis, and venulitis. These are absent in PSC-increased IgG4, which is characterized by a typical circular thickness in different parts of the biliary ducts. Finally, PSC is associated with inflammatory bowel disease, which is rare in IgG4-related SC, and more frequently is associated with cholangiocarcinomas and colon cancers. As distinct from IgG4-related SC, PSC is not a primary autoimmune disease.
ER  -

KUNOVSKÝ, Lumír, Petr DITE, Ľubomíra HORŇÁKOVÁ, Jiří DOLINA, Magdalena UVIROVA, Vladimír KOJECKÝ, Arnost MARTINEK a Petr JABANDŽIEV. Differentiating Primary Sclerosing Cholangitis from Similar Diseases of Autoimmune Origin. \textit{Journal of Gastrointestinal and Liver Diseases}. CLUJ-NAPOCA: MEDICAL UNIV PRESS, 2021, roč.~30, č.~3, s.~398-403. ISSN~1841-8724. Dostupné z: https://dx.doi.org/10.15403/jgld-3849.

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