J 2021

Impact of Multiphase Computed Tomography Angiography for Endovascular Treatment Decision-Making on Outcomes in Patients with Acute Ischemic Stroke

OSPEL, J. M., Ondřej VOLNÝ, W. QIU, M. NAJM, M. HAFEEZ et. al.

Základní údaje

Originální název

Impact of Multiphase Computed Tomography Angiography for Endovascular Treatment Decision-Making on Outcomes in Patients with Acute Ischemic Stroke

Autoři

OSPEL, J. M., Ondřej VOLNÝ (203 Česká republika, domácí), W. QIU, M. NAJM, M. HAFEEZ, S. ABDALRAHMAN, E. FAINARDI, M. RUBIERA, A. KHAW, J. J. SHANKAR, M. D. HILL, M. A. ALMEKHLAFI, A. M. DEMCHUK, M. GOYAL a B. K. MENON

Vydání

JOURNAL OF STROKE, SEOUL, KOREAN STROKE SOC, 2021, 2287-6391

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Korejská republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 8.632

Kód RIV

RIV/00216224:14110/21:00123032

Organizační jednotka

Lékařská fakulta

UT WoS

000703882200007

Klíčová slova anglicky

Ischemic stroke; Ischemia; Cerebrovascular circulation

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 29. 11. 2021 14:14, Mgr. Tereza Miškechová

Anotace

V originále

Background and Purpose Various imaging paradigms are used for endovascular treatment (EVT) decision-making and outcome estimation in acute ischemic stroke (AIS). We aim to compare how these imaging paradigms perform for EVT patient selection and outcome estimation. Methods Prospective multi-center cohort study of patients with AIS symptoms with multi-phase computed tomography angiography (mCTA) and computed tomography perfusion (CTP) baseline imaging. mCTA-based EVT-eligibility was defined as presence of large vessel occlusion (LVO) and moderate-to-good collaterals on mCTA. CTP-based eligibility was defined as presence of LVO, ischemic core (defined on relative cerebral blood flow, absolute cerebral blood flow, and cerebral blood volume maps) <70 mL, mismatch-ratio >1.8, absolute mismatch >15 mL. EVT-eligibility and adjusted rates of good outcome (modified Rankin Scale 0-2) based on these imaging paradigms were compared. Results Of 289/464 patients with LVO, 263 (91%) were EVT-eligible by mCTA-criteria versus 63 (22%), 19 (7%) and 103 (36%) by rCBF, aCBF, and CBV-CTP-criteria. CTP and mCTA-criteria were discordant in 40% to 53%. Estimated outcomes were best in patients who met both mCTA and CTP eligibility-criteria and were treated with EVT (62% to 87% good outcome). Patients eligible for EVT by mCTA-criteria and not by CTP-criteria receiving EVT achieved good outcome rates of 53% to 57%. Few patients met CTP-criteria and not mCTA-criteria for EVT. Conclusions Simpler imaging selection criteria that rely on little else than detection of the occluded blood vessel may be more sensitive and less specific, thus resulting in more patients being offered EVT and arguably benefiting from it.