Tumour Microenvironment Stress Promotes the Development of Drug
Resistance

J 2021

Tumour Microenvironment Stress Promotes the Development of Drug Resistance

SEEBACHER, Nicole A., Mária KRCHNIAKOVÁ, Alexandra E. STACY, Jan ŠKODA, Patric J. JANSSON et. al.

Základní údaje

Originální název

Tumour Microenvironment Stress Promotes the Development of Drug Resistance

Autoři

SEEBACHER, Nicole A., Mária KRCHNIAKOVÁ (703 Slovensko, domácí), Alexandra E. STACY, Jan ŠKODA (203 Česká republika, domácí) a Patric J. JANSSON

Vydání

Antioxidants, Basel, MDPI, 2021, 2076-3921

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.675

Kód RIV

RIV/00216224:14310/21:00119405

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/antiox10111801

UT WoS

000724516000001

Klíčová slova anglicky

tumour microenvironmental stress; drug resistance; reactive oxygen species; cancer stem cells

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 12. 2021 14:41, Mgr. Marie Šípková, DiS.

Anotace

V originále

Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to play an essential role in not only cancer progression and metastasis, but also the development of resistance to chemotherapy. Despite the significant advances in the efficacy of anti-cancer therapies, the development of drug resistance remains a major impediment to therapeutic success. This review highlights the interplay between various factors within the TME that collectively initiate or propagate MDR. The key TME-mediated mechanisms of MDR regulation that will be discussed herein include (1) altered metabolic processing and the reactive oxygen species (ROS)-hypoxia inducible factor (HIF) axis; (2) changes in stromal cells; (3) increased cancer cell survival via autophagy and failure of apoptosis; (4) altered drug delivery, uptake, or efflux and (5) the induction of a cancer stem cell (CSC) phenotype. The review also discusses thought-provoking ideas that may assist in overcoming the TME-induced MDR. We conclude that stressors from the TME and exposure to chemotherapeutic agents are strongly linked to the development of MDR in cancer cells. Therefore, there remains a vast area for potential research to further elicit the interplay between factors existing both within and outside the TME. Elucidating the mechanisms within this network is essential for developing new therapeutic strategies that are less prone to failure due to the development of resistance in cancer cells.

Návaznosti

GJ20-00987Y, projekt VaV

Název: Mitochondriální dynamika a autofagie: Chybějící článek mezi dediferenciací a vznikem rezistence u solidních nádorů dětského věku

Investor: Grantová agentura ČR, Mitochondrial dynamics and autophagy: A missing link between dedifferentiation and development of resistance in pediatric solid tumors

Citovat

SEEBACHER, Nicole A., Mária KRCHNIAKOVÁ, Alexandra E. STACY, Jan ŠKODA a Patric J. JANSSON. Tumour Microenvironment Stress Promotes the Development of Drug Resistance. Antioxidants. Basel: MDPI, 2021, roč. 10, č. 11, s. 1801-1832. ISSN 2076-3921. Dostupné z: https://dx.doi.org/10.3390/antiox10111801.

@article{1808501,
   author = {Seebacher, Nicole A. and Krchniaková, Mária and Stacy, Alexandra E. and Škoda, Jan and Jansson, Patric J.},
   article_location = {Basel},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/antiox10111801},
   keywords = {tumour microenvironmental stress; drug resistance; reactive oxygen species; cancer stem cells},
   language = {eng},
   issn = {2076-3921},
   journal = {Antioxidants},
   title = {Tumour Microenvironment Stress Promotes the Development of Drug Resistance},
   url = {https://www.mdpi.com/2076-3921/10/11/1801},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1808501
AU  - Seebacher, Nicole A. - Krchniaková, Mária - Stacy, Alexandra E. - Škoda, Jan - Jansson, Patric J.
PY  - 2021
TI  - Tumour Microenvironment Stress Promotes the Development of Drug Resistance
JF  - Antioxidants
VL  - 10
IS  - 11
SP  - 1801
EP  - 1801
PB  - MDPI
SN  - 20763921
KW  - tumour microenvironmental stress
KW  - drug resistance
KW  - reactive oxygen species
KW  - cancer stem cells
UR  - https://www.mdpi.com/2076-3921/10/11/1801
N2  - Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to play an essential role in not only cancer progression and metastasis, but also the development of resistance to chemotherapy. Despite the significant advances in the efficacy of anti-cancer therapies, the development of drug resistance remains a major impediment to therapeutic success. This review highlights the interplay between various factors within the TME that collectively initiate or propagate MDR. The key TME-mediated mechanisms of MDR regulation that will be discussed herein include (1) altered metabolic processing and the reactive oxygen species (ROS)-hypoxia inducible factor (HIF) axis; (2) changes in stromal cells; (3) increased cancer cell survival via autophagy and failure of apoptosis; (4) altered drug delivery, uptake, or efflux and (5) the induction of a cancer stem cell (CSC) phenotype. The review also discusses thought-provoking ideas that may assist in overcoming the TME-induced MDR. We conclude that stressors from the TME and exposure to chemotherapeutic agents are strongly linked to the development of MDR in cancer cells. Therefore, there remains a vast area for potential research to further elicit the interplay between factors existing both within and outside the TME. Elucidating the mechanisms within this network is essential for developing new therapeutic strategies that are less prone to failure due to the development of resistance in cancer cells.
ER  -

SEEBACHER, Nicole A., Mária KRCHNIAKOVÁ, Alexandra E. STACY, Jan ŠKODA a Patric J. JANSSON. Tumour Microenvironment Stress Promotes the Development of Drug Resistance. \textit{Antioxidants}. Basel: MDPI, 2021, roč.~10, č.~11, s.~1801-1832. ISSN~2076-3921. Dostupné z: https://dx.doi.org/10.3390/antiox10111801.

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