Human stem cells-sources, sourcing and in vitro methods

J 2021

Human stem cells-sources, sourcing and in vitro methods

SZUBARGA, Alicja; Marta KAMIŃSKA; Wiktoria KOTLARZ; Stefan MALEWSKI; Wiktoria ZAWADA et al.

Základní údaje

Originální název

Human stem cells-sources, sourcing and in vitro methods

Autoři

SZUBARGA, Alicja; Marta KAMIŃSKA; Wiktoria KOTLARZ; Stefan MALEWSKI; Wiktoria ZAWADA; Matylda KUCZMA; Michal JEŠETA a Paweł ANTOSIK

Vydání

Medical Journal of Cell Biology, Warsaw, Walter de Gruyter, 2021, 2544-3577

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/21:00123199

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.2478/acb-2021-0011

EID Scopus

2-s2.0-85109157198

Klíčová slova anglicky

animal model; in vitro; mesenchymal stem cell; Stem cell; stem cell therapy

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 12. 2021 14:54, Mgr. Tereza Miškechová

Anotace

V originále

Stem cells are an important subject of research, and are increasingly used in the treatment of various diseases. Due to the development of advanced in vitro techniques, they have become an integral part of modern medicine. The sources of human stem cells are primarily bone marrow and adipose tissue, although non-embryonic stem cells are also scattered throughout the body. Notably, recent research has focused on stem cells found in the oral cavity, both in the dental pulp and oral mucosa. Furthermore, isolation of stem cells from umbilical cord blood is also becoming increasingly popular, while wharton's jelly and amniotic fluid also seem to be an interesting source of stem cells. The safety and efficacy of stem cells use can be established by animal studies, which are a key element of preclinical research. Mouse, rat and pig models allow for testing of stem cell therapies. Recent studies primarily use mesenchymal stem cells such as mouse-adipose derived mesenchymal stem cells and mouse and rat hematopoietic stem cells. Great hope for future therapies is the use of bioengineering to program cells into induced stem cells, which have the biggest ability for differentiation and transdifferentiation, which carries no risk of teratogenesis. Stem cells are used in many areas of medicine, especially in regenerative medicine, with a growing interest in orthopedics and in the treatment of heart failure. Mesenchymal stem cells are the most used stem cell type, which despite their limited ability to differentiate, give great therapeutic results, mainly due to their immunomodulating effect. Recent studies have even shown that the use of mesenchymal stem cells may be useful in the treatment of COVID-19. Moreover, Research on the use of mesenchymal stem cells in the treatment of Crohn's disease, acute-graft-versus-host disease and type I diabetes are also promising. The aim of the current review is to present and systematize current knowledge about stem cells, their use and related in vitro research. Running title: Research and use of human stem cells.

Citovat

SZUBARGA, Alicja; Marta KAMIŃSKA; Wiktoria KOTLARZ; Stefan MALEWSKI; Wiktoria ZAWADA; Matylda KUCZMA; Michal JEŠETA a Paweł ANTOSIK. Human stem cells-sources, sourcing and in vitro methods. Medical Journal of Cell Biology. Warsaw: Walter de Gruyter, 2021, roč. 9, č. 2, s. 73-85. ISSN 2544-3577. Dostupné z: https://doi.org/10.2478/acb-2021-0011.

@article{1808503,
   author = {Szubarga, Alicja and Kamińska, Marta and Kotlarz, Wiktoria and Malewski, Stefan and Zawada, Wiktoria and Kuczma, Matylda and Ješeta, Michal and Antosik, Paweł},
   article_location = {Warsaw},
   article_number = {2},
   doi = {https://doi.org/10.2478/acb-2021-0011},
   keywords = {animal model; in vitro; mesenchymal stem cell; Stem cell; stem cell therapy},
   language = {eng},
   issn = {2544-3577},
   journal = {Medical Journal of Cell Biology},
   title = {Human stem cells-sources, sourcing and in vitro methods},
   url = {https://sciendo.com/article/10.2478/acb-2021-0011},
   volume = {9},
   year = {2021}
}

TY  - JOUR
ID  - 1808503
AU  - Szubarga, Alicja - Kamińska, Marta - Kotlarz, Wiktoria - Malewski, Stefan - Zawada, Wiktoria - Kuczma, Matylda - Ješeta, Michal - Antosik, Paweł
PY  - 2021
TI  - Human stem cells-sources, sourcing and in vitro methods
JF  - Medical Journal of Cell Biology
VL  - 9
IS  - 2
SP  - 73-85
EP  - 73-85
PB  - Walter de Gruyter
SN  - 25443577
KW  - animal model
KW  - in vitro
KW  - mesenchymal stem cell
KW  - Stem cell
KW  - stem cell therapy
UR  - https://sciendo.com/article/10.2478/acb-2021-0011
N2  - Stem cells are an important subject of research, and are increasingly used in the treatment of various diseases. Due to the development of advanced in vitro techniques, they have become an integral part of modern medicine. The sources of human stem cells are primarily bone marrow and adipose tissue, although non-embryonic stem cells are also scattered throughout the body. Notably, recent research has focused on stem cells found in the oral cavity, both in the dental pulp and oral mucosa. Furthermore, isolation of stem cells from umbilical cord blood is also becoming increasingly popular, while wharton's jelly and amniotic fluid also seem to be an interesting source of stem cells. The safety and efficacy of stem cells use can be established by animal studies, which are a key element of preclinical research. Mouse, rat and pig models allow for testing of stem cell therapies. Recent studies primarily use mesenchymal stem cells such as mouse-adipose derived mesenchymal stem cells and mouse and rat hematopoietic stem cells. Great hope for future therapies is the use of bioengineering to program cells into induced stem cells, which have the biggest ability for differentiation and transdifferentiation, which carries no risk of teratogenesis. Stem cells are used in many areas of medicine, especially in regenerative medicine, with a growing interest in orthopedics and in the treatment of heart failure. Mesenchymal stem cells are the most used stem cell type, which despite their limited ability to differentiate, give great therapeutic results, mainly due to their immunomodulating effect. Recent studies have even shown that the use of mesenchymal stem cells may be useful in the treatment of COVID-19. Moreover, Research on the use of mesenchymal stem cells in the treatment of Crohn's disease, acute-graft-versus-host disease and type I diabetes are also promising. The aim of the current review is to present and systematize current knowledge about stem cells, their use and related in vitro research. Running title: Research and use of human stem cells.
ER  -

SZUBARGA, Alicja; Marta KAMI$\backslash$'NSKA; Wiktoria KOTLARZ; Stefan MALEWSKI; Wiktoria ZAWADA; Matylda KUCZMA; Michal JEŠETA a Paweł ANTOSIK. Human stem cells-sources, sourcing and in vitro methods. \textit{Medical Journal of Cell Biology}. Warsaw: Walter de Gruyter, 2021, roč.~9, č.~2, s.~73-85. ISSN~2544-3577. Dostupné z: https://doi.org/10.2478/acb-2021-0011.

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