Gene expression of cytokinesis regulators PRC1, KIF14 and CIT
has no prognostic role in colorectal and pancreatic cancer

J 2021

Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer

HANICINEC, Vojtech, Veronika BRYNYCHOVA, Jachym ROSENDORF, Richard PALEK, Vaclav LISKA et. al.

Základní údaje

Originální název

Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer

Autoři

HANICINEC, Vojtech (203 Česká republika), Veronika BRYNYCHOVA (203 Česká republika), Jachym ROSENDORF (203 Česká republika), Richard PALEK (203 Česká republika), Vaclav LISKA (203 Česká republika), Martin OLIVERIUS (203 Česká republika), Zdeněk KALA (203 Česká republika, domácí), Beatrice MOHELNIKOVA-DUCHONOVA (203 Česká republika), Ivona KRUS (203 Česká republika) a Pavel SOUCEK (203 Česká republika, garant)

Vydání

Oncology Letters, Athens, Spandidos Publications, 2021, 1792-1074

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.111

Kód RIV

RIV/00216224:14110/21:00123229

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3892/ol.2021.12859

UT WoS

000667256200001

Klíčová slova anglicky

gene expression; cytokinesis; colon; rectum; pancreas; cancer; prognosis

Štítky

14110223, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 12. 2021 10:54, Mgr. Tereza Miškechová

Anotace

V originále

Colorectal cancer is one of the most common cancers and pancreatic cancer is among the most fatal and difficult to treat. New prognostic biomarkers are urgently needed to improve the treatment of colorectal and pancreatic cancer. Protein regulating cytokinesis 1 (PRC1), kinesin family member 14 (KIF14) and citron Rho-interacting serine/threonine kinase (CIT) serve important roles in cytokinesis, are strongly associated with cancer progression and have prognostic potential. The present study aimed to investigate the prognostic relevance of the PRC1, KIF14 and CIT genes in colorectal and pancreatic cancer. PRC1, KIF14 and CIT transcript expression was assessed by reverse transcription-quantitative PCR in tumors and paired distant unaffected mucosa from 67 patients with colorectal cancer and tumors and paired non-neoplastic control tissues from 48 patients with pancreatic cancer. The extent of transcript dysregulation between tumor and control tissues and between groups of patients divided by main clinical characteristics, namely patients' age and sex, disease stage, localization and grade, was determined. Finally, the associations of transcript levels in tumors with disease-free interval and overall survival time were evaluated. PRC1, KIF14 and CIT transcripts were upregulated in tumors compared with control tissues. PRC1, KIF14 and CIT levels strongly correlated to each other in both colorectal and pancreatic tumor and control tissues after correction for multiple testing. However, no significant associations were found among the transcript levels of PRC1, KIF14 and CIT and disease-free interval or overall survival time. In summary, the present study demonstrated mutual correlation of PRC1, KIF14 and CIT cytokinesis regulators with no clear prognostic value in pancreatic and colorectal cancers. Hence, according to the results of the present study, transcript levels of these genes cannot be clinically exploited as prognostic biomarkers in colorectal or pancreatic cancer patients.

Citovat

HANICINEC, Vojtech, Veronika BRYNYCHOVA, Jachym ROSENDORF, Richard PALEK, Vaclav LISKA, Martin OLIVERIUS, Zdeněk KALA, Beatrice MOHELNIKOVA-DUCHONOVA, Ivona KRUS a Pavel SOUCEK. Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer. Oncology Letters. Athens: Spandidos Publications, 2021, roč. 22, č. 2, s. 1-12. ISSN 1792-1074. Dostupné z: https://dx.doi.org/10.3892/ol.2021.12859.

@article{1809397,
   author = {Hanicinec, Vojtech and Brynychova, Veronika and Rosendorf, Jachym and Palek, Richard and Liska, Vaclav and Oliverius, Martin and Kala, Zdeněk and MohelnikovaandDuchonova, Beatrice and Krus, Ivona and Soucek, Pavel},
   article_location = {Athens},
   article_number = {2},
   doi = {http://dx.doi.org/10.3892/ol.2021.12859},
   keywords = {gene expression; cytokinesis; colon; rectum; pancreas; cancer; prognosis},
   language = {eng},
   issn = {1792-1074},
   journal = {Oncology Letters},
   title = {Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer},
   url = {https://www.spandidos-publications.com/10.3892/ol.2021.12859},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1809397
AU  - Hanicinec, Vojtech - Brynychova, Veronika - Rosendorf, Jachym - Palek, Richard - Liska, Vaclav - Oliverius, Martin - Kala, Zdeněk - Mohelnikova-Duchonova, Beatrice - Krus, Ivona - Soucek, Pavel
PY  - 2021
TI  - Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer
JF  - Oncology Letters
VL  - 22
IS  - 2
SP  - 1-12
EP  - 1-12
PB  - Spandidos Publications
SN  - 17921074
KW  - gene expression
KW  - cytokinesis
KW  - colon
KW  - rectum
KW  - pancreas
KW  - cancer
KW  - prognosis
UR  - https://www.spandidos-publications.com/10.3892/ol.2021.12859
N2  - Colorectal cancer is one of the most common cancers and pancreatic cancer is among the most fatal and difficult to treat. New prognostic biomarkers are urgently needed to improve the treatment of colorectal and pancreatic cancer. Protein regulating cytokinesis 1 (PRC1), kinesin family member 14 (KIF14) and citron Rho-interacting serine/threonine kinase (CIT) serve important roles in cytokinesis, are strongly associated with cancer progression and have prognostic potential. The present study aimed to investigate the prognostic relevance of the PRC1, KIF14 and CIT genes in colorectal and pancreatic cancer. PRC1, KIF14 and CIT transcript expression was assessed by reverse transcription-quantitative PCR in tumors and paired distant unaffected mucosa from 67 patients with colorectal cancer and tumors and paired non-neoplastic control tissues from 48 patients with pancreatic cancer. The extent of transcript dysregulation between tumor and control tissues and between groups of patients divided by main clinical characteristics, namely patients' age and sex, disease stage, localization and grade, was determined. Finally, the associations of transcript levels in tumors with disease-free interval and overall survival time were evaluated. PRC1, KIF14 and CIT transcripts were upregulated in tumors compared with control tissues. PRC1, KIF14 and CIT levels strongly correlated to each other in both colorectal and pancreatic tumor and control tissues after correction for multiple testing. However, no significant associations were found among the transcript levels of PRC1, KIF14 and CIT and disease-free interval or overall survival time. In summary, the present study demonstrated mutual correlation of PRC1, KIF14 and CIT cytokinesis regulators with no clear prognostic value in pancreatic and colorectal cancers. Hence, according to the results of the present study, transcript levels of these genes cannot be clinically exploited as prognostic biomarkers in colorectal or pancreatic cancer patients.
ER  -

HANICINEC, Vojtech, Veronika BRYNYCHOVA, Jachym ROSENDORF, Richard PALEK, Vaclav LISKA, Martin OLIVERIUS, Zdeněk KALA, Beatrice MOHELNIKOVA-DUCHONOVA, Ivona KRUS a Pavel SOUCEK. Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer. \textit{Oncology Letters}. Athens: Spandidos Publications, 2021, roč.~22, č.~2, s.~1-12. ISSN~1792-1074. Dostupné z: https://dx.doi.org/10.3892/ol.2021.12859.

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