2021
Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer - A Systematic Review
HUDEČKOVÁ, Markéta, Vladimír KOUCKÝ, Jan ROTTENBERG a Břetislav GÁLZákladní údaje
Originální název
Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer - A Systematic Review
Název česky
Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer - A Systematic Review
Autoři
HUDEČKOVÁ, Markéta (203 Česká republika, domácí), Vladimír KOUCKÝ (203 Česká republika), Jan ROTTENBERG (203 Česká republika, domácí) a Břetislav GÁL (203 Česká republika, garant, domácí)
Vydání
BIOMEDICINES, BASEL, MDPI, 2021, 2227-9059
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30206 Otorhinolaryngology
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 4.757
Kód RIV
RIV/00216224:14110/21:00123265
Organizační jednotka
Lékařská fakulta
UT WoS
000722923900001
Klíčová slova česky
head and neck cancer squamous cell carcinoma (HNSCC); circulating tumour DNA (ctDNA); diagnostic biomarker; liquid biopsy
Klíčová slova anglicky
head and neck cancer squamous cell carcinoma (HNSCC); circulating tumour DNA (ctDNA); diagnostic biomarker; liquid biopsy
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 17. 5. 2022 12:41, Mgr. Tereza Miškechová
V originále
Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common malignancies globally. An early diagnosis of this disease is crucial, and the detection of gene mutations in circulating tumour DNA (ctDNA) through a liquid biopsy is a promising non-invasive diagnostic method. This review aims to provide an overview of ctDNA mutations in HNSCC patients and discuss the potential use of this tool in diagnosis and prognosis. (2) Methods: A systematic search for articles published in the English language between January 2000 and April 2021 in the Medline and Scopus databases was conducted. (3) Results: A total of 10 studies published in nine publications were selected and analysed. Altogether, 390 samples were obtained from HNSCC patients, and 79 control samples were evaluated. The most often explored gene mutation in ctDNA was TP53. (4) Conclusions: The examination of a larger group of gene mutations and the use of a combination of multiple detection methods contribute to a higher detection rate of mutated ctDNA. More studies are necessary to verify these conclusions and to translate them into clinical practice.
Česky
Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common malignancies globally. An early diagnosis of this disease is crucial, and the detection of gene mutations in circulating tumour DNA (ctDNA) through a liquid biopsy is a promising non-invasive diagnostic method. This review aims to provide an overview of ctDNA mutations in HNSCC patients and discuss the potential use of this tool in diagnosis and prognosis. (2) Methods: A systematic search for articles published in the English language between January 2000 and April 2021 in the Medline and Scopus databases was conducted. (3) Results: A total of 10 studies published in nine publications were selected and analysed. Altogether, 390 samples were obtained from HNSCC patients, and 79 control samples were evaluated. The most often explored gene mutation in ctDNA was TP53. (4) Conclusions: The examination of a larger group of gene mutations and the use of a combination of multiple detection methods contribute to a higher detection rate of mutated ctDNA. More studies are necessary to verify these conclusions and to translate them into clinical practice.
Návaznosti
| MUNI/A/1002/2018, interní kód MU |
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