Hyaluronan: A key player or just a bystander in skin
photoaging?

J 2022

Hyaluronan: A key player or just a bystander in skin photoaging?

ŠÍNOVÁ, Romana; Vojtěch PAVLÍK; Martin ONDREJ; Vladimír VELEBNÝ; Kristina NEŠPOROVÁ et al.

Základní údaje

Originální název

Hyaluronan: A key player or just a bystander in skin photoaging?

Autoři

ŠÍNOVÁ, Romana; Vojtěch PAVLÍK; Martin ONDREJ; Vladimír VELEBNÝ a Kristina NEŠPOROVÁ

Vydání

Experimental Dermatology, Wiley, 2022, 0906-6705

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.600

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00125121

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

ECM; hyaluronan; inflammation; senescence; UV radiation

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 4. 2023 08:04, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Photoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide component thereof. HA is a structurally simple but biologically complex molecule that serves as a water-retaining component and provides both a scaffold for a number of the proteins of the ECM and the ligand for cellular receptors. The study provides an overview of the literature concerning the changes in HA amount, size and metabolism, and the potential role of HA in photoaging. We also suggest novel HA contributions to photoaging based on our knowledge of the role of HA in other pathological processes, including the senescence and inflammation-triggered ECM reorganization. Moreover, we discuss potential direct or indirect intervention to mitigate photoaging that targets the hyaluronan metabolism, as well as supplementation.

Citovat

ŠÍNOVÁ, Romana; Vojtěch PAVLÍK; Martin ONDREJ; Vladimír VELEBNÝ a Kristina NEŠPOROVÁ. Hyaluronan: A key player or just a bystander in skin photoaging? Experimental Dermatology. Wiley, 2022, roč. 31, č. 4, s. 442-458. ISSN 0906-6705. Dostupné z: https://doi.org/10.1111/exd.14491.

@article{1815957,
   author = {Šínová, Romana and Pavlík, Vojtěch and Ondrej, Martin and Velebný, Vladimír and Nešporová, Kristina},
   article_number = {4},
   doi = {https://doi.org/10.1111/exd.14491},
   keywords = {ECM; hyaluronan; inflammation; senescence; UV radiation},
   language = {eng},
   issn = {0906-6705},
   journal = {Experimental Dermatology},
   title = {Hyaluronan: A key player or just a bystander in skin photoaging?},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/exd.14491},
   volume = {31},
   year = {2022}
}

TY  - JOUR
ID  - 1815957
AU  - Šínová, Romana - Pavlík, Vojtěch - Ondrej, Martin - Velebný, Vladimír - Nešporová, Kristina
PY  - 2022
TI  - Hyaluronan: A key player or just a bystander in skin photoaging?
JF  - Experimental Dermatology
VL  - 31
IS  - 4
SP  - 442-458
EP  - 442-458
PB  - Wiley
SN  - 09066705
KW  - ECM
KW  - hyaluronan
KW  - inflammation
KW  - senescence
KW  - UV radiation
UR  - https://onlinelibrary.wiley.com/doi/10.1111/exd.14491
N2  - Photoaged skin exhibits signs of inflammation, DNA damage and changes in morphology that are visible at the macroscopic and microscopic levels. Photoaging also affects the extracellular matrix (ECM) including hyaluronan (HA), the main polysaccharide component thereof. HA is a structurally simple but biologically complex molecule that serves as a water-retaining component and provides both a scaffold for a number of the proteins of the ECM and the ligand for cellular receptors. The study provides an overview of the literature concerning the changes in HA amount, size and metabolism, and the potential role of HA in photoaging. We also suggest novel HA contributions to photoaging based on our knowledge of the role of HA in other pathological processes, including the senescence and inflammation-triggered ECM reorganization. Moreover, we discuss potential direct or indirect intervention to mitigate photoaging that targets the hyaluronan metabolism, as well as supplementation.
ER  -

ŠÍNOVÁ, Romana; Vojtěch PAVLÍK; Martin ONDREJ; Vladimír VELEBNÝ a Kristina NEŠPOROVÁ. Hyaluronan: A key player or just a bystander in skin photoaging? \textit{Experimental Dermatology}. Wiley, 2022, roč.~31, č.~4, s.~442-458. ISSN~0906-6705. Dostupné z: https://doi.org/10.1111/exd.14491.

Přehled o publikaci