Challenges of stem cell application in research and clinical
practice - an update

J 2021

Challenges of stem cell application in research and clinical practice - an update

JANKOWSKI, Maurycy; Marie MACHATKOVA; Pavel VENTRUBA; Elena KISTANOVA; Alexander MAKAREVICH et al.

Základní údaje

Originální název

Challenges of stem cell application in research and clinical practice - an update

Autoři

JANKOWSKI, Maurycy; Marie MACHATKOVA; Pavel VENTRUBA; Elena KISTANOVA; Alexander MAKAREVICH; Radek PROCHAZKA a Michal JEŠETA

Vydání

Medical Journal of Cell Biology, Warsaw, Walter de Gruyter, 2021, 2544-3577

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/21:00129660

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.2478/acb-2021-0022

EID Scopus

999

Klíčová slova anglicky

stem cells; ethical challenges; research; therapy

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 2. 2023 09:26, Mgr. Tereza Miškechová

Anotace

V originále

There are multiple possible applications of stem cells in medicine, from cell-based therapies for degenerative and dystrophic conditions, through novel approaches in cancer treatment, to in vitro organ printing. However, there are still several challenges that need to be overcame before stem cells therapies can be successfully introduced worldwide on a large scale. These include sourcing of stem cells, preventing their aberrant progression and ethical concerns regarding their use in animals and humans. Among the multiple stem cell types present in the human organism from the period of embryonic development to adulthood, this review focuses on the three types that gain the most attention in relation to modern research: embryonic stem cells, induced pluripotent stem cells and adult stem cells. There are a number of obstacles that need to be removed before these cells can be widely applied in clinical practice, including the choice of the perfect source of stem cells, full elucidation of the mechanisms of stem cell differentiation and plasticity, and minimization of adverse side effect potential. Nonetheless, the focus of the scientific community on the topic of stem cells remains unhindered, bringing hope that all of the possible concerns will be addressed in the future.

Návaznosti

NV18-08-00412, projekt VaV

Název: Lidské embryonální kmenové buňky pro klinické aplikace: derivace a charakterizace

Investor: Ministerstvo zdravotnictví ČR, Lidské embryonální kmenové buňky pro klinické aplikace: derivace a charakterizace

Citovat

JANKOWSKI, Maurycy; Marie MACHATKOVA; Pavel VENTRUBA; Elena KISTANOVA; Alexander MAKAREVICH; Radek PROCHAZKA a Michal JEŠETA. Challenges of stem cell application in research and clinical practice - an update. Medical Journal of Cell Biology. Warsaw: Walter de Gruyter, 2021, roč. 9, č. 4, s. 160-164. ISSN 2544-3577. Dostupné z: https://doi.org/10.2478/acb-2021-0022.

@article{1823833,
   author = {Jankowski, Maurycy and Machatkova, Marie and Ventruba, Pavel and Kistanova, Elena and Makarevich, Alexander and Prochazka, Radek and Ješeta, Michal},
   article_location = {Warsaw},
   article_number = {4},
   doi = {https://doi.org/10.2478/acb-2021-0022},
   keywords = {stem cells; ethical challenges; research; therapy},
   language = {eng},
   issn = {2544-3577},
   journal = {Medical Journal of Cell Biology},
   title = {Challenges of stem cell application in research and clinical practice - an update},
   url = {https://sciendo.com/es/article/10.2478/acb-2021-0022},
   volume = {9},
   year = {2021}
}

TY  - JOUR
ID  - 1823833
AU  - Jankowski, Maurycy - Machatkova, Marie - Ventruba, Pavel - Kistanova, Elena - Makarevich, Alexander - Prochazka, Radek - Ješeta, Michal
PY  - 2021
TI  - Challenges of stem cell application in research and clinical practice - an update
JF  - Medical Journal of Cell Biology
VL  - 9
IS  - 4
SP  - 160-164
EP  - 160-164
PB  - Walter de Gruyter
SN  - 25443577
KW  - stem cells
KW  - ethical challenges
KW  - research
KW  - therapy
UR  - https://sciendo.com/es/article/10.2478/acb-2021-0022
N2  - There are multiple possible applications of stem cells in medicine, from cell-based therapies for degenerative and dystrophic conditions, through novel approaches in cancer treatment, to in vitro organ printing. However, there are still several challenges that need to be overcame before stem cells therapies can be successfully introduced worldwide on a large scale. These include sourcing of stem cells, preventing their aberrant progression and ethical concerns regarding their use in animals and humans. Among the multiple stem cell types present in the human organism from the period of embryonic development to adulthood, this review focuses on the three types that gain the most attention in relation to modern research: embryonic stem cells, induced pluripotent stem cells and adult stem cells. There are a number of obstacles that need to be removed before these cells can be widely applied in clinical practice, including the choice of the perfect source of stem cells, full elucidation of the mechanisms of stem cell differentiation and plasticity, and minimization of adverse side effect potential. Nonetheless, the focus of the scientific community on the topic of stem cells remains unhindered, bringing hope that all of the possible concerns will be addressed in the future.
ER  -

JANKOWSKI, Maurycy; Marie MACHATKOVA; Pavel VENTRUBA; Elena KISTANOVA; Alexander MAKAREVICH; Radek PROCHAZKA a Michal JEŠETA. Challenges of stem cell application in research and clinical practice - an update. \textit{Medical Journal of Cell Biology}. Warsaw: Walter de Gruyter, 2021, roč.~9, č.~4, s.~160-164. ISSN~2544-3577. Dostupné z: https://doi.org/10.2478/acb-2021-0022.

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