Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry
DE LUCA, G.; N. DEBEL; M. CERCEK; L. O. JENSEN; M. VAVLUKIS et al.
Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry
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DE LUCA, G.; N. DEBEL; M. CERCEK; L. O. JENSEN; M. VAVLUKIS; L. CALMAC; T. JOHNSON; G. R. FERRER; V. GANYUKOV; W. WOJAKOWSKI; T . KINNAIRD; C. VON BIRGELEN; Y. COTTIN; A. IJSSELMUIDEN; B. TUCCILLO; F. VERSACI; K. J . ROYAARDS; J. TEN BERG; M. LAINE; M. DIRKSEN; M. SIVIGLIA; G. CASELLA; Petr KALA; J. L. D. GIL; A. BANNING; V . BECERRA; C. DE SIMONE; A. SANTUCCI; X. CARRILLO; A. SCOCCIA; G. AMOROSO; A. W. VAN'T HOF; T. KOVARNIK; G. TSIGKAS; J. MEHILLI; G. GABRIELLI; X. F. RIOS; N. BAKRACESKI; S. LEVESQUE; G. CIRRINCIONE; V. GUIDUCCI; M. KIDAWA; L. SPEDICATO; L. MARINUCCI; P. LUDMAN; F. ZILIO; G. GALASSO; E. FABRIS; M. MENICHELLI; A. GARCIA-TOUCHARD; S. MANZO; G. CAIAZZO; J. MOREU; J. S. FORES; L. DONAZZAN; L. VIGNALI; R. TELES; E. BENIT; P. AGOSTONI; F. B. OJEDA; H. LEHTOLA; S. CAMACHO-FREIERE; A. KRAAIJEVELD; Y. ANTTI; M. BOCCALATTE; P. DEHARO; I. L. MARTINEZ-LUENGAS; B. SCHELLER; E. VARYTIMIADI; R. MORENO; G. UCCELLO; B. FAURIE; A. G. BARRIOS; M. MILEWSKI; E. BRUWIERE; P. SMITS; B. WILBERT; F. S. DI UCCIO; G. PARODI; E. KEDHI a M. VERDOIA
Background and aims: SARS-Cov-2 predisposes patients to thrombotic complications, due to excessive inflam-mation, endothelial dysfunction, platelet activation, and coagulation/fibrinolysis disturbances. The aim of the present study was to evaluate clinical characteristics and prognostic impact of SARS-CoV-2 positivity among STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Methods: We selected SARS-CoV-2 positive patients included in the ISACS-STEMI COVID-19, a retrospective multicenter European registry including 6609 STEMI patients treated with PPCI from March 1st until April 30th, in 2019 and 2020. As a reference group, we randomly sampled 5 SARS-Cov-2 negative patients per each SARS-CoV-2 positive patient, individually matched for age, sex, and hospital/geographic area. Study endpoints were in-hospital mortality, definite stent thrombosis, heart failure. Results: Our population is represented by 62 positive SARS-CoV-2 positive patients who were compared with a matched population of 310 STEMI patients. No significant difference was observed in baseline characteristics or the modality of access to the PCI center. In the SARS-CoV-2 positive patients, the culprit lesion was more often located in the RCA (p < 0.001). Despite similar pre and postprocedural TIMI flow, we observed a trend in higher use of GP IIb-IIIa inhibitors and a significantly higher use of thrombectomy in the SARS-CoV-2 positive patients. SARS-CoV-2 positivity was associated with a remarkably higher in hospital mortality (29% vs 5.5%, p < 0.001), definite in-stent thrombosis (8.1% vs 1.6%, p symbolscript 0.004) and heart failure (22.6% vs 10.6%, p symbolscript 0.001) that was confirmed after adjustment for confounding factors. Conclusions: Our study showed that among STEMI patients, SARS-CoV-2 positivity is associated with larger thrombus burden, a remarkably higher mortality but also higher rates of in-stent thrombosis and heart failure.
DE LUCA, G.; N. DEBEL; M. CERCEK; L. O. JENSEN; M. VAVLUKIS; L. CALMAC; T. JOHNSON; G. R. FERRER; V. GANYUKOV; W. WOJAKOWSKI; T . KINNAIRD; C. VON BIRGELEN; Y. COTTIN; A. IJSSELMUIDEN; B. TUCCILLO; F. VERSACI; K. J . ROYAARDS; J. TEN BERG; M. LAINE; M. DIRKSEN; M. SIVIGLIA; G. CASELLA; Petr KALA; J. L. D. GIL; A. BANNING; V . BECERRA; C. DE SIMONE; A. SANTUCCI; X. CARRILLO; A. SCOCCIA; G. AMOROSO; A. W. VAN'T HOF; T. KOVARNIK; G. TSIGKAS; J. MEHILLI; G. GABRIELLI; X. F. RIOS; N. BAKRACESKI; S. LEVESQUE; G. CIRRINCIONE; V. GUIDUCCI; M. KIDAWA; L. SPEDICATO; L. MARINUCCI; P. LUDMAN; F. ZILIO; G. GALASSO; E. FABRIS; M. MENICHELLI; A. GARCIA-TOUCHARD; S. MANZO; G. CAIAZZO; J. MOREU; J. S. FORES; L. DONAZZAN; L. VIGNALI; R. TELES; E. BENIT; P. AGOSTONI; F. B. OJEDA; H. LEHTOLA; S. CAMACHO-FREIERE; A. KRAAIJEVELD; Y. ANTTI; M. BOCCALATTE; P. DEHARO; I. L. MARTINEZ-LUENGAS; B. SCHELLER; E. VARYTIMIADI; R. MORENO; G. UCCELLO; B. FAURIE; A. G. BARRIOS; M. MILEWSKI; E. BRUWIERE; P. SMITS; B. WILBERT; F. S. DI UCCIO; G. PARODI; E. KEDHI a M. VERDOIA. Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry. Atherosclerosis. Clare: ELSEVIER SCI IRELAND LTD, 2021, roč. 332, September 2021, s. 48-54. ISSN 0021-9150. Dostupné z: https://doi.org/10.1016/j.atherosclerosis.2021.06.926.
@article{1824020, author = {De Luca, G. and Debel, N. and Cercek, M. and Jensen, L. O. and Vavlukis, M. and Calmac, L. and Johnson, T. and Ferrer, G. R. and Ganyukov, V. and Wojakowski, W. and Kinnaird, T . and von Birgelen, C. and Cottin, Y. and IJsselmuiden, A. and Tuccillo, B. and Versaci, F. and Royaards, K. J . and ten Berg, J. and Laine, M. and Dirksen, M. and Siviglia, M. and Casella, G. and Kala, Petr and Gil, J. L. D. and Banning, A. and Becerra, V . and De Simone, C. and Santucci, A. and Carrillo, X. and Scoccia, A. and Amoroso, G. and van't Hof, A. W. and Kovarnik, T. and Tsigkas, G. and Mehilli, J. and Gabrielli, G. and Rios, X. F. and Bakraceski, N. and Levesque, S. and Cirrincione, G. and Guiducci, V. and Kidawa, M. and Spedicato, L. and Marinucci, L. and Ludman, P. and Zilio, F. and Galasso, G. and Fabris, E. and Menichelli, M. and GarciaandTouchard, A. and Manzo, S. and Caiazzo, G. and Moreu, J. and Fores, J. S. and Donazzan, L. and Vignali, L. and Teles, R. and Benit, E. and Agostoni, P. and Ojeda, F. B. and Lehtola, H. and CamachoandFreiere, S. and Kraaijeveld, A. and Antti, Y. and Boccalatte, M. and Deharo, P. and MartinezandLuengas, I. L. and Scheller, B. and Varytimiadi, E. and Moreno, R. and Uccello, G. and Faurie, B. and Barrios, A. G. and Milewski, M. and Bruwiere, E. and Smits, P. and Wilbert, B. and Di Uccio, F. S. and Parodi, G. and Kedhi, E. and Verdoia, M.}, article_location = {Clare}, article_number = {September 2021}, doi = {https://doi.org/10.1016/j.atherosclerosis.2021.06.926}, keywords = {SARS-CoV-2; ST segment elevation myocardial infarction; Thrombosis(please add them)}, language = {eng}, issn = {0021-9150}, journal = {Atherosclerosis}, title = {Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry}, url = {https://www.sciencedirect.com/science/article/pii/S0021915021012156?via%3Dihub}, volume = {332}, year = {2021} }
TY - JOUR ID - 1824020 AU - De Luca, G. - Debel, N. - Cercek, M. - Jensen, L. O. - Vavlukis, M. - Calmac, L. - Johnson, T. - Ferrer, G. R. - Ganyukov, V. - Wojakowski, W. - Kinnaird, T . - von Birgelen, C. - Cottin, Y. - IJsselmuiden, A. - Tuccillo, B. - Versaci, F. - Royaards, K. J . - ten Berg, J. - Laine, M. - Dirksen, M. - Siviglia, M. - Casella, G. - Kala, Petr - Gil, J. L. D. - Banning, A. - Becerra, V . - De Simone, C. - Santucci, A. - Carrillo, X. - Scoccia, A. - Amoroso, G. - van't Hof, A. W. - Kovarnik, T. - Tsigkas, G. - Mehilli, J. - Gabrielli, G. - Rios, X. F. - Bakraceski, N. - Levesque, S. - Cirrincione, G. - Guiducci, V. - Kidawa, M. - Spedicato, L. - Marinucci, L. - Ludman, P. - Zilio, F. - Galasso, G. - Fabris, E. - Menichelli, M. - Garcia-Touchard, A. - Manzo, S. - Caiazzo, G. - Moreu, J. - Fores, J. S. - Donazzan, L. - Vignali, L. - Teles, R. - Benit, E. - Agostoni, P. - Ojeda, F. B. - Lehtola, H. - Camacho-Freiere, S. - Kraaijeveld, A. - Antti, Y. - Boccalatte, M. - Deharo, P. - Martinez-Luengas, I. L. - Scheller, B. - Varytimiadi, E. - Moreno, R. - Uccello, G. - Faurie, B. - Barrios, A. G. - Milewski, M. - Bruwiere, E. - Smits, P. - Wilbert, B. - Di Uccio, F. S. - Parodi, G. - Kedhi, E. - Verdoia, M. PY - 2021 TI - Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry JF - Atherosclerosis VL - 332 IS - September 2021 SP - 48-54 EP - 48-54 PB - ELSEVIER SCI IRELAND LTD SN - 00219150 KW - SARS-CoV-2 KW - ST segment elevation myocardial infarction KW - Thrombosis(please add them) UR - https://www.sciencedirect.com/science/article/pii/S0021915021012156?via%3Dihub N2 - Background and aims: SARS-Cov-2 predisposes patients to thrombotic complications, due to excessive inflam-mation, endothelial dysfunction, platelet activation, and coagulation/fibrinolysis disturbances. The aim of the present study was to evaluate clinical characteristics and prognostic impact of SARS-CoV-2 positivity among STEMI patients undergoing primary percutaneous coronary intervention (PPCI). Methods: We selected SARS-CoV-2 positive patients included in the ISACS-STEMI COVID-19, a retrospective multicenter European registry including 6609 STEMI patients treated with PPCI from March 1st until April 30th, in 2019 and 2020. As a reference group, we randomly sampled 5 SARS-Cov-2 negative patients per each SARS-CoV-2 positive patient, individually matched for age, sex, and hospital/geographic area. Study endpoints were in-hospital mortality, definite stent thrombosis, heart failure. Results: Our population is represented by 62 positive SARS-CoV-2 positive patients who were compared with a matched population of 310 STEMI patients. No significant difference was observed in baseline characteristics or the modality of access to the PCI center. In the SARS-CoV-2 positive patients, the culprit lesion was more often located in the RCA (p < 0.001). Despite similar pre and postprocedural TIMI flow, we observed a trend in higher use of GP IIb-IIIa inhibitors and a significantly higher use of thrombectomy in the SARS-CoV-2 positive patients. SARS-CoV-2 positivity was associated with a remarkably higher in hospital mortality (29% vs 5.5%, p < 0.001), definite in-stent thrombosis (8.1% vs 1.6%, p symbolscript 0.004) and heart failure (22.6% vs 10.6%, p symbolscript 0.001) that was confirmed after adjustment for confounding factors. Conclusions: Our study showed that among STEMI patients, SARS-CoV-2 positivity is associated with larger thrombus burden, a remarkably higher mortality but also higher rates of in-stent thrombosis and heart failure. ER -
DE LUCA, G.; N. DEBEL; M. CERCEK; L. O. JENSEN; M. VAVLUKIS; L. CALMAC; T. JOHNSON; G. R. FERRER; V. GANYUKOV; W. WOJAKOWSKI; T . KINNAIRD; C. VON BIRGELEN; Y. COTTIN; A. IJSSELMUIDEN; B. TUCCILLO; F. VERSACI; K. J . ROYAARDS; J. TEN BERG; M. LAINE; M. DIRKSEN; M. SIVIGLIA; G. CASELLA; Petr KALA; J. L. D. GIL; A. BANNING; V . BECERRA; C. DE SIMONE; A. SANTUCCI; X. CARRILLO; A. SCOCCIA; G. AMOROSO; A. W. VAN'T HOF; T. KOVARNIK; G. TSIGKAS; J. MEHILLI; G. GABRIELLI; X. F. RIOS; N. BAKRACESKI; S. LEVESQUE; G. CIRRINCIONE; V. GUIDUCCI; M. KIDAWA; L. SPEDICATO; L. MARINUCCI; P. LUDMAN; F. ZILIO; G. GALASSO; E. FABRIS; M. MENICHELLI; A. GARCIA-TOUCHARD; S. MANZO; G. CAIAZZO; J. MOREU; J. S. FORES; L. DONAZZAN; L. VIGNALI; R. TELES; E. BENIT; P. AGOSTONI; F. B. OJEDA; H. LEHTOLA; S. CAMACHO-FREIERE; A. KRAAIJEVELD; Y. ANTTI; M. BOCCALATTE; P. DEHARO; I. L. MARTINEZ-LUENGAS; B. SCHELLER; E. VARYTIMIADI; R. MORENO; G. UCCELLO; B. FAURIE; A. G. BARRIOS; M. MILEWSKI; E. BRUWIERE; P. SMITS; B. WILBERT; F. S. DI UCCIO; G. PARODI; E. KEDHI a M. VERDOIA. Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry. \textit{Atherosclerosis}. Clare: ELSEVIER SCI IRELAND LTD, 2021, roč.~332, September 2021, s.~48-54. ISSN~0021-9150. Dostupné z: https://doi.org/10.1016/j.atherosclerosis.2021.06.926.